A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review

Kooshki, Fateme; Tutunchi, Helda; Vajdi, Mahdi; Karimi, Arash; Niazkar, Hamid Reza; Shoorei, Hamed; Gargari, Bahram Pourghassem

doi:10.1111/1440-1681.13462

Cited by 22 publications

(12 citation statements)

References 102 publications

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“…The effects of VM leaves as a complementary treatment for diabetes have been correlated in traditional medicine with the chromium content. Trivalent chromium is considered to be an insulin sensitizer by modulating the phosphorylation of insulin-binding receptors [ 55 , 56 ]. Nevertheless, as shown in Table 7 , the concentration of chromium in leaves is low; therefore, the effects cannot be entirely attributed to the chromium content.…”

Section: Chemical Compositionmentioning

confidence: 99%

An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology

et al. 2022

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Bilberry leaves are used in many countries in traditional medicine for treating a wide variety of diseases. Due to the high therapeutic potential of Vaccinium myrtillus (VM) leaves, this review aims to present the latest knowledge on the phytochemical profile, as well as the therapeutic effects of this herbal drug. The review was conducted according to the Prisma guidelines, and the scientific databases were searched using combinations of the following keywords: “Vaccinium myrtillus”, “leaves”, “bilberry”. Recent research was focused on the influence of abiotic factors on the phytochemical composition, and it seems that there are significant differences between the herbal drugs collected from different countries. The phytochemical composition is correlated with the broad spectrum of pharmacological effects. The paper outlines the potent antimicrobial activity of VM extracts against multidrug-resistant bacterial strains, and also the pathways that are modulated by the unique “cocktail” of phytoconstituents in different metabolic alterations. Reviewing the research articles published in the last 10 years, it seems that bilberry leaves have been slightly forgotten, although their phytochemical and pharmacological characteristics are unique.

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Section: Chemical Compositionmentioning

confidence: 99%

An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology

et al. 2022

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Diabetes mellitus (DM) is one of the most important chronic endocrine and chronic metabolic diseases characterised by continuous hyperglycaemia, mostly caused by a deficiency or lack of insulin secretion, insulin resistance or both. [1][2][3] The prevalence of diabetes in 2013 was nearly 382 million cases, and this number will increase to 529 million adults by 2035. 4,5 It is also estimated that by 2040, 642 million people will develop diabetes, especially in developing countries.

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mentioning

confidence: 99%

A comprehensive mechanistic and therapeutic insight into the effect of chicory ( Cichorium intybus ) supplementation in diabetes mellitus: A systematic review of literature

Azgomi

Karimi

Tutunchi

et al. 2021

Int J Clinical Practice

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Background Cichorium intybus is a rich source of terpenoids and phenolic compounds, one of the effective methods in managing and reducing the complications of chronic diseases such as diabetes mellitus. The purpose of this systematic review was to evaluate the evidence obtained from animal and human studies on the effects of chicory on metabolic indicators (such as inflammation, oxidative stress, blood sugar and dyslipidaemia) of diabetes mellitus. Materials and methods This systematic search was performed in ProQuest, PubMed, Google Scholar, Scopus, Cochrane Central Register of Controlled Trials, Embase and Science Direct databases and on articles published until August 2021. All of the animal studies and clinical trials included in this systematic review that assessed the effect of chicory on metabolic risk markers in diabetes were published in English language journals. Results Finally, amongst 686 articles, only 23 articles met the needed criteria for further analysis. Out of 23 articles, 3 studies on humans and 20 studies on animals have been carried out. Fifteen of the 19 studies that evaluated the effect of chicory on the glycaemic index showed that Cichorium intybus improved blood glucose index (it had no effect in two human studies and three animal studies). Ten of the 13 studies evaluating the effect of Cichorium intybus on lipid profiles showed that it improved dyslipidaemia. Also, all 12 studies showed that chicory significantly reduces oxidative stress and inflammation. Conclusion According to the available evidence, Cichorium intybus might improve the glycaemic status, dyslipidaemia, oxidative stress and inflammation. However, further studies are recommended for a comprehensive conclusion about the exact mechanism of chicory in diabetic patients.

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“…The beneficial effect of Cr(III) on antioxidant status in DM was also reported by some authors [ 75 , 76 ]. A recent extensive review concluded that chromium supplementation decreases oxidative stress in diabetes mellitus [ 77 ]. In summary, the positive impact of supplementation with SG combined with L-arginine and Cr(III) on the antioxidant status observed in this study is consistent with previous observations.…”

Section: Discussionmentioning

confidence: 99%

Steviol Glycoside, L-Arginine, and Chromium(III) Supplementation Attenuates Abnormalities in Glucose Metabolism in Streptozotocin-Induced Mildly Diabetic Rats Fed a High-Fat Diet

et al. 2022

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Stevia rebaudiana Bertoni and its glycosides are believed to exhibit several health-promoting properties. Recently, the mechanisms of the anti-diabetic effects of steviol glycosides (SG) have been the subject of intense research. The following study aims to evaluate the results of SG (stevioside (ST) and rebaudioside A (RA)) combined with L-arginine (L-Arg) and chromium(III) (CrIII) supplementation in streptozotocin- (STZ) induced mild type 2 diabetic rats fed a high-fat diet (HFD), with particular emphasis on carbohydrate and lipid metabolisms. The experiment was carried out on 110 male Wistar rats, 100 of which were fed an HFD to induce insulin resistance, followed by an intraperitoneal injection of streptozotocin to induce mild type 2 diabetes. After confirmation of hyperglycemia, the rats were divided into groups. Three groups served as controls: diabetic untreated, diabetic treated with metformin (300 mg/kg BW), and healthy group. Eight groups were fed an HFD enriched with stevioside or rebaudioside A (2500 mg/kg BW) combined with L-arginine (2000 or 4000 mg/kg BW) and Cr(III) (1 or 5 mg/kg BW) for six weeks. The results showed that supplementation with SG (ST and RA) combined with L-arg and Cr(III) could improve blood glucose levels in rats with mild type 2 diabetes. Furthermore, ST was more effective in improving blood glucose levels, insulin resistance indices, and very low-density lipoprotein cholesterol (VLDL-C) concentrations than RA. Although L-arg and Cr(III) supplementation did not independently affect most blood carbohydrate and lipid indices, it further improved some biomarkers when combined, particularly with ST. Notably, the beneficial impact of ST on the homeostatic model assessment–insulin resistance (HOMA-IR) and on the quantitative insulin-sensitivity check index (QUICKI) was strengthened when mixed with a high dose of L-arg, while its impact on antioxidant status was improved when combined with a high dose of Cr(III) in rats with mild type 2 diabetes. In conclusion, these results suggest that supplementary stevioside combined with L-arginine and Cr(III) has therapeutic potential for mild type 2 diabetes. However, further studies are warranted to confirm these effects in other experimental models and humans.

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A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review

Cited by 22 publications

References 102 publications

An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology

An Updated Systematic Review of Vaccinium myrtillus Leaves: Phytochemistry and Pharmacology

A comprehensive mechanistic and therapeutic insight into the effect of chicory ( Cichorium intybus ) supplementation in diabetes mellitus: A systematic review of literature

Steviol Glycoside, L-Arginine, and Chromium(III) Supplementation Attenuates Abnormalities in Glucose Metabolism in Streptozotocin-Induced Mildly Diabetic Rats Fed a High-Fat Diet

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