A comprehensive insight into effects of resveratrol on molecular mechanism in rheumatoid arthritis: A literature systematic review

Abstract

Aim Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, which is characterized by massive pain and destruction of synovial joints, leads to bone erosion, damage to cartilage, and disability. Several studies suggested that resveratrol supplementation may be effective in the prevention and management of RA. Therefore, a systematic review was conducted to summarize published studies that assess the effect of resveratrol supplementation on the complications of RA. Methods A comprehensive search to identify in vitro, animal, and human studies investigating the impact of resveratrol on the complications of RA was performed up to February 2022. Two independent reviewers evaluated studies based on inclusion/exclusion criteria and performed data extraction. Results All studies examining the effects of resveratrol supplementation on the complications of RA were included. From a total of 571 retrieved articles, 32 studies were eligible for the current systematic review. The evidence reviewed here indicates that resveratrol supplementation may exert beneficial effects on the complications of RA by attenuating inflammation and oxidative stress, modulating the immune response, and down‐regulating the messenger RNA expression of genes related to inflammatory pathways. Conclusion Due to the promising therapeutic effects of resveratrol on RA complications and limited number of human studies in this subject, further clinical trials are suggested.

Celecoxib and Etoricoxib may reduce risk of ischemic stroke in patients with rheumatoid arthritis: A nationwide retrospective cohort study

“…However, they overlooked the effects of prostaglandin, which is cellular inflammation and pain. By reducing part of the mechanism that induces cardiovascular events, our hypothesis is that this would result in reduction of ischemic stroke, as evidenced by the data presented in our cohort study (40,44,(46)(47)(48)(49)(50). Conversely, due to the reduction in prostaglandin production by COX enzyme inhibition, there might be related gastrointestinal side effects such as gastric ulcers.…”

New classification criteria for juvenile idiopathic arthritis

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Stroke risk in rheumatoid arthritis patients: exploring connections and implications for patient care

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