A comprehensive evaluation of the toxicology of cigarette ingredients: aromatic carbonyl compounds

In this paper, we present for the first time the use of high-resolution magic angle spinning nuclear magnetic resonance (HRMAS NMR) spectroscopy combined with chemometrics as an alternative tool for the characterization of tobacco products from different commercial international brands as well as for the identification of counterfeits. Although cigarette filling is a very complex chemical mixture, we were able to discriminate between dark, bright, and additive-free cigarette blends belonging to six different filter-cigarette brands, commercially available, using an approach for which no extraction procedure is required. Second, we focused our study on a specific worldwide-distributed brand for which established counterfeits were available. We discriminated those from their genuine counterparts with 100% accuracy using unsupervised multivariate statistical analysis. The counterfeits that we analyzed showed a higher amount of nicotine and solanesol and a lower content of sugars, all endogenous tobacco leaf metabolites. This preliminary study demonstrates the great potential of HRMAS NMR spectroscopy to help in controlling cigarette authenticity.

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HRMAS NMR spectroscopy combined with chemometrics as an alternative analytical tool to control cigarette authenticity

Shintu

Caldarelli

Campredon

2013

Anal Bioanal Chem

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A Review on Selective Production of Acetophenone from Oxidation of Ethylbenzene over Heterogeneous Catalysts in a Decade

et al. 2021

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A test strategy for the assessment of additive attributed toxicity of tobacco products

Kienhuis

Staal

Soeteman‐Hernández

et al. 2016

Food and Chemical Toxicology

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A comprehensive evaluation of the toxicology of cigarette ingredients: aromatic carbonyl compounds

Abstract: Even at the exaggerated inclusion levels in cigarette tobacco used in these tests, no adverse toxicological responses occurred for any of aromatic carbonyl compounds tested.

Cited by 8 publications

References 13 publications

HRMAS NMR spectroscopy combined with chemometrics as an alternative analytical tool to control cigarette authenticity

HRMAS NMR spectroscopy combined with chemometrics as an alternative analytical tool to control cigarette authenticity

A Review on Selective Production of Acetophenone from Oxidation of Ethylbenzene over Heterogeneous Catalysts in a Decade

A test strategy for the assessment of additive attributed toxicity of tobacco products

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