A Comprehensive Computational Insight into the PD-L1 Binding to PD-1 and Small Molecules
Marialuigia Fantacuzzi,
Roberto Paciotti,
Mariangela Agamennone
Abstract:Immunotherapy has marked a revolution in cancer therapy. The most extensively studied target in this field is represented by the protein–protein interaction between PD-1 and its ligand, PD-L1. The promising results obtained with the clinical use of monoclonal antibodies (mAbs) directed against both PD-1 and PD-L1 have prompted the search for small-molecule binders capable of disrupting the protein–protein contact and overcoming the limitations presented by mAbs. The disclosure of the first X-ray complexes of P… Show more
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