A comprehensive bioinformatics analysis of THOC3 highlights its potential role in pan-cancer and clinical significance in lung adenocarcinoma

Abstract

THOC3, a crucial component of the THO complex, is involved in mRNA biosynthesis and export. Studies have shown that dysregulation of THOC3 is linked to various aspects of tumorigenesis, including tumor initiation, progression, and metastasis. In this study, we utilized a comprehensive bioinformatics analysis to explore the role of THOC3 in different types of cancer. Our analysis of different types of data helped us understand how THOC3 contributes to cancer at the molecular level, and its clinical significance. Moreover, our immune analysis revealed notable correlations between THOC3 and multiple immune-related signaling pathways. Our findings highlight the potential oncogenic role of THOC3 across different types of cancer and propose dysregulation of THOC3 as a key driver in tumor development. Furthermore, the associations between THOC3 and immune-related signaling pathways indicate its potential as a target for further experimental validation and investigation in the realm of immunotherapy.