A Comprehensive Behavioural Assessment of Curcumin’s Effect on Inflammatory and Non-Inflammatory Pain in Mice

Abstract

The present study aimed to assess the effect of oral curcumin administration on different types of experimental pain and to evaluate its effect on motor activity and coordination. The study was conducted on mice were divided in 4 groups and which received different doses of curcumin through gavage or olive oil (control). Tail Flick, Hot Plate, Rota Rod and Activity Cage tests were performed at baseline and 30, 60, 120, 180 and 240 minutes after administration. The most efficient dose (120 mg/kg bw) was chosen for the subsequent assessment. The group that received 120 mg/kg bw oral curcumin had an increased pain tolerance in both Tail Flick and Hot Plate tests. Curcumin had no effect on paw formalin-induced pain, but significantly decreased the pain-related behaviour in the orofacial formalin-induced pain test and in the visceral pain test. The substance had no influence on motor activity or coordination. Our study proved that curcumin administrated by gavage is effective in nociceptive, visceral and inflammatory experimental pain even after single-dose administration. Rezumat Obiectivele studiului au fost evaluarea efectului administrării orale a curcuminei în diferite tipuri de durere experimentală și asupra activității motorii și a coordonării. Șoarecii incluși în studiu au fost împărțiți în 4 grupuri și au primit, prin gavaj, doze diferite de curcumină sau ulei de măsline (control). Testele Tail Flick, Hot Plate, Rota Rod și Activity Cage au fost efectuate atât înainte cât și la 30, 60, 120, 180 și 240 minute după administrare. Doza cea mai eficientă (120 mg/kgc) a fost aleasă pentru evaluările ulterioare. Grupul care a primit 120 mg/kgc curcumină orală a avut toleranță crescută la durere, atât la testul Tail Flick, cât și Hot Plate. Curcumina nu a avut nici un efect asupra durerii-induse-de-formalină de la nivelul labei, dar a scăzut semnificativ comportamentul indus de durere, la testul pentru durere orofacială indusă de formalină și testul durerii viscerale. Substanța nu a avut nici o influență asupra activității motorii sau coordonării. Studiul evidențiază faptul că administrarea curcuminei prin gavaj este eficientă în durerea experimentală nociceptivă, viscerală și inflamatorie, chiar după administrarea unei singure doze.

Impacts of Curcumin Treatment on Experimental Sepsis: A Systematic Review

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Evaluation of Tapering Biological Therapy in Rheumatoid Arthritis

“…Modern treatments, dynamic or intrusive, such as step-up and treat-to-target schemes (recommended by the EULAR -European League Against Rheumatism) built on therapy adjustment until LDA or remission is gained, are feasible and consensual objective for RA patients [3]. It is well known that DMARD therapy is begun as soon as the diagnosis is confirmed [1]. The body of evidence has grown in the last decade, particularly for the targeted synthetic (ts) DMARDs inhibiting Janus Kinase inhibitor (JAKi), novel biological (b) DMARDs aiming acknowledged pathways and trials comparing bDMARDs to other bDMARDs or tsDMARDs.…”

Curcumin Co-Loaded With a Lipid Mediator in the Same Nanostructured Lipid Delivery System

“…For example, turmeric (Curcuma longa Linn) is a member of the Zingiberaceae family and is cultivated in tropical and subtropical regions around the world, coming from India, South East Asia and Indonesia [2]. Turmeric is one of the most popular medicinal herbs, with a wide range of pharmacological activities such as antioxidant [3], antimicrobial, anti-malarial [4], anti-inflammatory [5], anti-angiogenic, anti-tumoural [6] and antiaging [7] properties. The pharmacological activity of turmeric has been attributed mainly to curcuminoids, consisting of curcumin and two related derivatives (e.g.…”