A comprehensive analysis on Symplocos racemosa Roxb.: Traditional uses, botany, phytochemistry and pharmacological activities

Acharya, Niyati; Acharya, Sanjeev; Shah, Unnati; Shah, Ripal; Hingorani, Lal

doi:10.1016/j.jep.2016.01.043

Cited by 30 publications

(28 citation statements)

References 41 publications

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“…The component plants of Lodhrasavam for example, S . racemosa Roxb., Terminalia chebula Retz., Phylanthus emblica Roxb., Embelia ribes , Piper retrofractum Vahl., have been independently studied and reported using various in vitro and in vivo models for their potential anti-diabetic and hypolipidimic effects [31] , [32] , [33] , [34] . But there are no scientific studies addressing the anti-diabetic and anti-adipogenic potentials of Lodhrasavam as a formulation.…”

Section: Resultsmentioning

confidence: 99%

Ayurvedic anti-diabetic formulation Lodhrasavam inhibits alpha-amylase, alpha-glucosidase and suppresses adipogenic activity in vitro

Butala

Kukkupuni

Vishnuprasad

2017

Journal of Ayurveda and Integrative Medicine

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BackgroundThe patho-physiological cross-talk between diabetes and obesity is well established. However, the choices of drugs suitable for combined treatment of diabetes and obesity are limited. Integration of complementary and alternative medicines (CAMs), like Ayurveda, with modern medicine would be a promising strategy to fill this gap. The diagnostic principles of Ayurveda define obesity as one of the predisposing factors of Madhumeha (correlated as diabetes) and recommends specific formulations for managing obese-diabetes. Lodhrasavam is one such poly-herbal formulation prescribed for obese-diabetic patients.ObjectivesThe present study is an attempt to demonstrate the possible modes of action of Lodhrasavam, built on the hypothesis that the formulation can exert both anti-diabetic and anti-obesity actions.Materials and methodsLodhrasavam, following simulated gastro-intestinal digestion, was monitored for inhibition of α-amylase, α-glucosidase (key digestive enzyme targets of anti-diabetic drugs) and adipogenesis using standard in vitro model systems.ResultsLodhrasavam digest inhibited α-amylase (90%) and α-glucosidase (78%) activity as well as reduced the differentiation of 3T3-L1 fibroblasts to adipocytes. Upon fractionation, the enzyme inhibitory activity and anti-adipogenic activity of the digest were found distributed in different solvent fractions. This partly indicates a potential pharmacological networking of chemically and functionally diverse bioactive molecules in Lodhrasavam.ConclusionThe study provides a possible mode of action and an experimental support for the Ayurvedic use of Lodhrasavam for managing obese-diabetes. Generating scientific evidences and understanding the modes of action, in contemporary scientific language, would essentially help in expanding global acceptance of potentials of CAMs in the management of life style disorders.

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Section: Resultsmentioning

confidence: 99%

Ayurvedic anti-diabetic formulation Lodhrasavam inhibits alpha-amylase, alpha-glucosidase and suppresses adipogenic activity in vitro

Butala

Kukkupuni

Vishnuprasad

2017

Journal of Ayurveda and Integrative Medicine

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“…Anti-atherosclerotic, reduces serum hyper lipidemia, useful in coronary heart disease [50] Chitraka (Plumbago zeylanica) Prevents platelet adhesion, prolongs bleeding time by altering platelet adhesion and coagulation [51] Musta (Cyperus rotundus) Antiplatelet aggregating activity [52] Katukarohini (Picrorhiza kurroa) Antithrombic, anti-inflammatory [53] Devadaru (Cedrus deodara) Antihyperglycemic [54] Samangaa (Rubia cordifolia) Antithrombic, antioxidant, blood purifier, regulates blood pressure and vaso constriction [55] Shalmali (Salmalia malabarica) Hypoglycemic, antihyperglycemic, analgesic [56] Udeechya (Pavonia odorata) Antidiabetic, hypoglycemic [57] Chandana (Santalum album) Antioxidant, NO scavenging activity, reduces angina pain, anti-inflammatory [58] Anti-hyperglycemic, antihyperlipidemic, cardio protective [59] Dhataki (Woodfordia fruticosa) Anti hyperglycemic, antioxidant [60] Anti-inflammatory, anti-nociceptive [61] Talisa (Abies webbiana) Inhibits platelet aggregation, useful in thrombo-embolic conditions [62] Kakamachi (Solanum nigrum) Antinociceptive, anti-inflammatory, antipyretic [63] Antidiabetic [64] Antioxidant, hypolipidemic [65] Lodhra (Symplocos recemosa) Antioxidant, anti-inflammatory, antidiabetic [66] Padmaka (Prunus puddum) Analgesic, antioxidant, diuretic [67] Gunja (Abrus precatorius) Antidiabetic [68] Antithrombic [69] Antiplatelet, antiviral, antioxidant, anti-inflammatory [65] Madanaphala (Randia dumetorum) Analgesic, anti-inflammatory [70] Antidiabetic, antihyperlipidaemic, anti-hyperglycemic, antioxidant [71] Danti (Baliospermum montanum) Antidiabetic, decreases blood sugar levels and serum cholesterol levels [72] Kutaja (Holarrhena antidysenterica) Antidiabetic, decreases serum cholesterol, triglycerides and increases liver glycogen [73] Chavya (Piper retrofractum) Antihypertensive [59] Murva (Marsdenia tenacissima) Antiobesity [74] Patha (Cissampelos pareira) Antidiabetic [75] Karanja (Pongamia pinnata) Antihyperglycemic [76] Nya...…”

Section: Internal Medicinesmentioning

confidence: 99%

Untitled

Mamidi

2017

IJGP

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Urustambha is a grave condition, in which the patient's thighs become painful, numb and immobile. Urustambha is a disease which is not amenable to panchakarma (five evacuative procedures) treatment. Till date, there is no clear understanding of the concept of Urustambha and its clinical application. This article is aimed to understand the concept of Urustambha and its correlation with relevant modern pathology or disease. Urustambha is a lifestyle disease and it is commonly seen in higher socioeconomic status. Urustambha samprapti resembles with atherogenesis. Diva swapna and raatri jaagarana explained in Urustambha nidaana may indicate obstructive sleep apnea (OSA). Clinical presentation of Urustambha may be unilateral or bilateral or both. Charaka's version of Urustambha indicates vascular pathology like "aortoiliac occlusion" with an underlying "metabolic syndrome (MS)," whereas Sushruta's version of Urustambha indicates inflammatory pathology of spinal cord like "acute transverse myelitis" or "inflammatory myelopathy" or "infectious myelitis." Principles of Urustambha are applicable for the prevention and management of the conditions like atherosclerosis, MS, OSA, aortoiliac occlusion, diabetes mellitus, obesity, cardiovascular pathology, acute myelopathy and other ischemic and inflammatory spinal diseases.

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“…Previous investigations indicated that those plants contain terpenoids, flavonoids, lignans, phenols, steroids, alkaloids, and iridoids [2]. These plants exhibited antipyretic, anti-inflammatory, antibacterial, antioxidant, and anticancer activities [2,3]. Symplocos sumuntia Buch.-Ham.…”

Section: Introductionmentioning

confidence: 99%

Investigation of anti-inflammatory lignans from the leaves of <i>Symplocos sumuntia</i> Buch-Ham ex D Don (Symplocaceae)

Hương¹,

Trâm²,

Minh³

et al. 2017

Trop. J. Pharm Res

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Purpose: To investigate the anti-inflammatory activity of Symplocos sumuntia Buch.-Ham. ex D. Don and identify the main secondary metabolites responsible for this effect. Methods: The in vitro anti-inflammatory activity of the plant extract and isolated compounds was determined in terms of the ability to inhibit the production of nitric oxide (NO), and expressions of iNOS and COX-2 proteins in RAW264.7 cells stimulated by lipopolysaccharide (LPS). Compounds were isolated and identified by spectroscopic methods. Results: The methanol extract of S. sumuntia leaves showed strong inhibitory effects on nitric oxide (NO) production and expression of iNOS and COX-2 in LPS-induced RAW264.7 cells. A phytochemical assay-guided fractionation of the methanol extract of S. sumuntia leaves led to the isolation of four lignans which are arctigenin (1), matairesinol (2), monomethylpinoresinol (3) and pinoresinol (4).

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A comprehensive analysis on Symplocos racemosa Roxb.: Traditional uses, botany, phytochemistry and pharmacological activities

Cited by 30 publications

References 41 publications

Ayurvedic anti-diabetic formulation Lodhrasavam inhibits alpha-amylase, alpha-glucosidase and suppresses adipogenic activity in vitro

Ayurvedic anti-diabetic formulation Lodhrasavam inhibits alpha-amylase, alpha-glucosidase and suppresses adipogenic activity in vitro

Untitled

Investigation of anti-inflammatory lignans from the leaves of <i>Symplocos sumuntia</i> Buch-Ham ex D Don (Symplocaceae)

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