A composition-based cartilage model for the assessment of compositional changes during cartilage damage and adaptation

Wilson, W.; Huyghe, Jmrj Jacques; Donkelaar, van Cc René

doi:10.1016/j.joca.2005.12.006

Cited by 100 publications

(159 citation statements)

References 33 publications

(61 reference statements)

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“…However, a composition based approach (e.g. Wilson et al (2007Wilson et al ( , 2006b ;Loboa et al (2003)) with cell-specific activities (such as for example demonstrated in Isaksson et al (2008b)) will be more suitable to capture such effects like age, species and tissue specific synthesis rates.…”

Section: Discussionmentioning

confidence: 99%

Mechano-regulation of mesenchymal stem cell differentiation and collagen organisation during skeletal tissue repair

Nagel

Kelly

2009

Biomech Model Mechanobiol

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A number of mechano-regulation theories have been proposed that relate the differentiation pathway of mesenchymal stem cells (MSCs) to their local biomechanical environment. During spontaneous repair processes in skeletal tissues, the organisation of the extracellular matrix is a key determinant of its mechanical fitness. In this paper we extend the mechano-regulation theory proposed by Prendergast et al (1997) to include the role of the mechanical environment on the collagen architecture in regenerating soft tissues. A large strain anisotropic poroelastic material model is used in a simulation of tissue differentiation in a fracture subject to cyclic bending (Cullinane et al, 2002). The model predicts non-union with cartilage and fibrous tissue formation in the defect. Predicted collagen fibre angles, as determined by the principal decomposition of strainand stress-type tensors, are similar to the architecture seen in native articular cartilage and neoarthroses induced by bending of mid-femoral defects in rats. Both stress and strain based remodelling stimuli successfully predicted the general patterns of collagen fibre organisation observed in vivo. This provides further evidence that collagen organisation during tissue differentiation is determined by the mechanical environment. It is envisioned that such predictive models can play a key role in optimising MSC based skeletal repair therapies where recapitulation of the normal tissue architecture

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Section: Discussionmentioning

confidence: 99%

Mechano-regulation of mesenchymal stem cell differentiation and collagen organisation during skeletal tissue repair

Nagel

Kelly

2009

Biomech Model Mechanobiol

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“…1). A validated composition-based fibril-reinforced poro-viscoelastic swelling material model was adopted in which the porous matrix of the biphasic tissue consisted of a swelling nonfibrillar ground substance, which contains mainly PG's and TE scaffold substance, and a fibrillar part representing the collagen network (Wilson et al 2004(Wilson et al , 2006b(Wilson et al , 2007. The mechanical behavior of the material model was the direct consequence of the composition (fluid fraction, collagen fraction, fixed charge density) and the structure (collagen orientation) of the tissue.…”

Section: Finite Element Mesh and Materials Modelmentioning

confidence: 99%

“…In all cases, PG's content in the implant was assumed to be 75% of the native tissue in agreement with experimental studies (Kelly et al 2006). Expressions for osmotic swelling pressure can be found in Wilson et al (2006b). Permeability was chosen to be twice that in native tissue (Buschmann et al 1992;Owen and Wayne 2006).…”

Section: Finite Element Mesh and Materials Modelmentioning

confidence: 99%

“…The functional significance of the specific physiological depth-dependent collagen structure in native tissue (with vertical fibers in the deep zone and horizontal fibers in the superficial zone) is well emphasized in the literature (Korhonen et al 2002;Owen and Wayne 2006;Wilson et al 2007;Korhonen et al 2008;Shirazi and ShiraziAdl 2008;. Vertical fibrils in the deep zone resist swelling (Wilson et al 2006b) and protects the solid matrix against large strains at the subchondral junction . The superficial zone plays a crucial role in resisting elevated tensile stresses parallel to the articular surface (Owen and Wayne 2006).…”

Section: Introductionmentioning

confidence: 99%

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The effect of tissue-engineered cartilage biomechanical and biochemical properties on its post-implantation mechanical behavior

Khoshgoftar

Wilson

Ito

et al. 2012

Biomech Model Mechanobiol

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The insufficient load-bearing capacity of today's tissue-engineered (TE) cartilage limits its clinical application. Focus has been on engineering cartilage with enhanced mechanical stiffness by reproducing native biochemical compositions. More recently, depth dependency of the biochemical content and the collagen network architecture has gained interest. However, it is unknown whether the mechanical performance of TE cartilage would benefit more from higher content of biochemical compositions or from achieving an appropriate collagen organization. Furthermore, the relative synthesis rate of collagen and proteoglycans during the TE process may affect implant performance. Such insights would assist tissue engineers to focus on those aspects that are most important. The aim of the present study is therefore to elucidate the relative importance of implant ground substance stiffness, collagen content, and collagen architecture of the implant, as well as the synthesis rate of the biochemical constituents for the post-implantation mechanical behavior of the implant. We approach this by computing the post-implantation mechanical conditions using a composition-based fibril-reinforced poro-viscoelastic swelling model of the medial tibia plateau. Results show that adverse implant composition and ultrastructure may lead to post-implantation excessive mechanical loads, with collagen orientation being

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“…Computer-guided study designs can be helpful in this context, and using computers to interpret and extrapolate experimental data may turn out to be the only way to break through the trial-and-error-like approaches that are adopted nowadays. In the past few years many different theoretical models for cartilage mechanics have been developed [82][83][84][85][86][87][88][89]. These models form the basis for computer models that are dedicated for describing cartilage tissue engineering [33,72,[90][91][92][93][94][95][96][97].…”

Section: Current and Future Developmentsmentioning

confidence: 99%

Review on Patents for Mechanical Stimulation of Articular Cartilage Tissue Engineering

Donkelaar¹,

Schulz

2008

BIOMENG

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Abstract:To repair articular cartilage defects in osteoarthritic patients with three-dimensional tissue engineered chondrocyte grafts, requires the formation of new cartilage with sufficient mechanical properties. The premise is that mechanical stimulation during the culturing process is necessary to reach this aim. Therefore, mechanical stimulation systems have been integrated in aseptic bioreactors for in vitro cultivation of tissue engineered cartilage. These vary from simple unconfined compression systems to advanced bioreactors in which deformation and loading are fully controlled. Fluid handling in these devices is another decisive parameter for the success of cartilage tissue engineering.Over the last decades bioreactor developments have resulted in the filing of many patents. The aim of this paper is to review these patents, categorize them according to their possibilities for mechanical stimulation and fluid handling systems and finally to discuss them in the context of the demands of a functional tissue engineered cartilage from a mechanical perspective.

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A composition-based cartilage model for the assessment of compositional changes during cartilage damage and adaptation

Cited by 100 publications

References 33 publications

Mechano-regulation of mesenchymal stem cell differentiation and collagen organisation during skeletal tissue repair

Mechano-regulation of mesenchymal stem cell differentiation and collagen organisation during skeletal tissue repair

The effect of tissue-engineered cartilage biomechanical and biochemical properties on its post-implantation mechanical behavior

Review on Patents for Mechanical Stimulation of Articular Cartilage Tissue Engineering

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