A Complete Genome Screen in Sib Pairs Affected by Gilles de la Tourette Syndrome

doi:10.1086/302613

Cited by 151 publications

(3 citation statements)

References 32 publications

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“…Mathews et al ( 2007 ) gathered lifetime data for children and adults diagnosed with Tourette’s disorder from two genetically isolated samples using the Yale Self Report Form (YSRF; Tourette Syndrome Association International Consortium for Genetics 1999 ). In each sample, they found evidence for two symptom clusters, a simple tic cluster and complex tic cluster, and that the complex tic cluster was positively associated with tic severity, impairment, and comorbid obsessive compulsive disorder (OCD) symptoms.…”

Section: Introductionmentioning

confidence: 99%

Cluster Analysis of the Yale Global Tic Severity Scale (YGTSS): Symptom Dimensions and Clinical Correlates in an Outpatient Youth Sample

Kircanski

Woods

Chang

et al. 2010

J Abnorm Child Psychol

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Tic disorders are heterogeneous, with symptoms varying widely both within and across patients. Exploration of symptom clusters may aid in the identification of symptom dimensions of empirical and treatment import. This article presents the results of two studies investigating tic symptom clusters using a sample of 99 youth (M age = 10.7, 81% male, 77% Caucasian) diagnosed with a primary tic disorder (Tourette’s disorder or chronic tic disorder), across two university-based outpatient clinics specializing in tic and related disorders. In Study 1, a cluster analysis of the Yale Global Tic Severity Scale (YGTSS) identified four symptom dimensions: predominantly complex tics; simple head/face tics; simple body tics; and simple vocal/facial tics. In Study 2, these clusters were shown to be differentially associated with demographic and clinical characteristics. Findings lend support to prior research on tic phenomenology, help to organize treatment goals, and suggest symptom dimensions of tic disorders for further evaluation.

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Section: Introductionmentioning

confidence: 99%

Cluster Analysis of the Yale Global Tic Severity Scale (YGTSS): Symptom Dimensions and Clinical Correlates in an Outpatient Youth Sample

Kircanski

Woods

Chang

et al. 2010

J Abnorm Child Psychol

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show abstract

“…We also reviewed the Diagnostic Confidence Index ( Robertson et al , 1999), the YGTSS ( Leckman et al , 1989; Storch et al , 2005), and the parent and child self-report forms used by the Tourette Syndrome Association International Consortium for Genetics (1999). An expert in psychiatric epidemiology (CWS) developed the questions that would be posed, in consultation with a movement-disorders-trained neuropsychiatrist (KJB).…”

Section: Methodsmentioning

confidence: 99%

VISIT-TS: A multimedia tool for population studies on tic disorders

et al. 2016

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Population-based assessment of Tourette syndrome (TS) and other tic disorders produces a paradox. On one hand, ideally diagnosis of tic disorders requires expert observation. In fact, diagnostic criteria for TS explicitly require expert assessment of tics for a definite diagnosis. On the other hand, large-scale population surveys with expert assessment of every subject are impracticable. True, several published studies have successfully used expert assessment to find tic prevalence in a representative population (e.g. all students in a school district). However, extending these studies to larger populations is daunting. We created a multimedia tool to demonstrate tics to a lay audience, discuss their defining and common attributes, and address features that differentiate tics from other movements and vocalizations. A first version was modified to improve clarity and to include a more diverse group in terms of age and ethnicity. The result is a tool intended for epidemiological research. It may also provide additional benefits, such as more representative minority recruitment for other TS studies and increased community awareness of TS.

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“…Although large linkage studies have been performed, a genome-wide screen for linkage using 386 markers did not show a limit of detection (LOD) score of more than two, 41 nor did a genome -wide screen based on 110 sib pairs, show significant loci. 42 A sample from a French-Canadian family (127 members, 20 to 40 affected) showed a LOD score greater than three on Hq23. 43 …”

Section: Genetics Of Tsmentioning

confidence: 99%

Tourette's syndrome: clinical features, pathophysiology, and therapeutic approaches.

Müller

2007

Dialogues in Clinical Neuroscience

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Tourette's syndrome (TS) is a disorder characterized by simple and complex motor tics, vocal tics, and frequently obsessive-compulsive symptoms. Its onset occurs before the age of 21. Typically, TS shows a waxing and waning course, but a chronification of the tics, even during later life, is often observed. TS mainly occurs in boys, and shows genetic heritability with differing penetrance. The pathological mechanism is still unclear Neuroanatomical and neuroimaging studies, as well as effective treatment using antipsychotics, suggest that a disturbance of the dopaminergic system in the basal ganglia plays an important role in the pathogenesis of TS. Several possibly causative mechanisms of the disturbed dopaminergic neurotransmission are discussed, with the main emphasis on the-infection-triggered-inflammatory immune process. Extrapyramidal movement disorders are known to occur as a symptom of poststreptococcal disease, such as in Sydenham's chorea. Cases of childhood TS are proposed to be caused by such a poststreptococcal mechanism, being part of a spectrum of childhood neurobehavioral disorders termed pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS). The overlap between TS and PANDAS is discussed, and a critical view of the PANDAS concept is presented. The therapeutic implications of the different pathological mechanisms are described, taking into consideration not only the acute or chronic natures of different infections, but also an autoimmune process. Moreover, therapeutic strategies using typical and atypical antipsychotics, and also experimental therapies such as repetitive transcranial magnetic stimulation and deep brain stimulation, are critically discussed.

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A Complete Genome Screen in Sib Pairs Affected by Gilles de la Tourette Syndrome

Cited by 151 publications

References 32 publications

Cluster Analysis of the Yale Global Tic Severity Scale (YGTSS): Symptom Dimensions and Clinical Correlates in an Outpatient Youth Sample

Cluster Analysis of the Yale Global Tic Severity Scale (YGTSS): Symptom Dimensions and Clinical Correlates in an Outpatient Youth Sample

VISIT-TS: A multimedia tool for population studies on tic disorders

Tourette's syndrome: clinical features, pathophysiology, and therapeutic approaches.

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