A Complete Comparative Chromosome Map for the Dog, Red Fox, and Human and Its Integration with Canine Genetic Maps

Yang, Fengtang; O’Brien, Patrícia C. M.; Milne, B.S.; Graphodatsky, Alexander S.; Solanky, Nita; Trifonov, Vladimir A.; Rens, Willem; Sargan, David R.; Ferguson-Smith, Malcolm A.

doi:10.1006/geno.1999.5989

Cited by 317 publications

(345 citation statements)

References 43 publications

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“…The sequence assembly validated much of what was already hypothesized from comparative genome map studies. The genome is approximately 2.4 billion bases and is comprised of approximately 250 conserved segments when compared to the human genome 16,17,21,[65][66][67] . The assembled sequence is estimated to cover 98% of the dog genome with the majority of genes containing no sequence gaps.…”

Section: Canine Genome Maps and The Canine Genome Sequencementioning

confidence: 99%

Finding cardiovascular disease genes in the dog

Parker

Meurs

Ostrander

2006

Journal of Veterinary Cardiology

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Recent advances in canine genomics are changing the landscape of veterinary biology, and by default, veterinary medicine. No longer are clinicians locked into traditional methods of diagnoses and therapy. Rather major advances in canine genetics and genomics from the past five years are now changing the way the veterinarian of the 21 st century practices medicine.First, the availability of a dense genome map gives canine genetics a much needed foothold in comparative medicine, allowing advances made in human and mouse genetics to be applied to companion animals. Second, the recently released 7.5x whole genome sequence of the dog is facilitating the identification of hereditary disease genes. Finally, development of genetic tools for rapid screening of families and populations at risk for inherited disease means that the cost of identifying and testing for disease loci will significantly decrease in coming years.Out of these advances will come major changes in companion animal diagnostics and therapy. Clinicians will be able to offer their clients genetic testing and counseling for a myriad of disorders. Such advances are certain to generate healthier and more long lived dogs, improving quality of life for owner and pet alike. The clinician of the 21 st century, therefore, faces incredible opportunities as well as challenges in the management of genetic disease. In this review we summarize recent findings in canine genomics and discuss their application to the study of canine cardiac health.

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Section: Canine Genome Maps and The Canine Genome Sequencementioning

confidence: 99%

Finding cardiovascular disease genes in the dog

Parker

Meurs

Ostrander

2006

Journal of Veterinary Cardiology

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“…The application of CGH to the dog (Dunn et al, 2000;Thomas et al, 2001), the advent of novel molecular cytogenetic resources for this species (Langford et al, 1996), the development of comparative cytogenetic maps (Breen et al, 1999aYang et al, 1999;Sargan et al, 2000) and the generation of an integrated canine genome map ) now provide a means by which to overcome prior practical difficulties and embark on more comprehensive studies of tumour karyotypes in this species. In addition to expanding our knowledge of the canine disease, the resulting comparative data will enable improved correlation between human and canine counterparts of a given cancer where they exist.…”

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confidence: 99%

Chromosome aberrations in canine multicentric lymphomas detected with comparative genomic hybridisation and a panel of single locus probes

et al. 2003

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Recurrent chromosome aberrations are frequently observed in human neoplastic cells and often correlate with other clinical and histopathological parameters of a given tumour type. The clinical presentation, histology and biology of many canine cancers closely parallels those of human malignancies. Since humans and dogs demonstrate extensive genome homology and share the same environment, it is expected that many canine cancers will also be associated with recurrent chromosome aberrations. To investigate this, we have performed molecular cytogenetic analyses on 25 cases of canine multicentric lymphoma. Comparative genomic hybridisation analysis demonstrated between one and 12 separate regions of chromosomal gain or loss within each case, involving 32 of the 38 canine autosomes. Genomic gains were almost twice as common as losses. Gain of dog chromosome (CFA) 13 was the most common aberration observed (12 of 25 cases), followed by gain of CFA 31 (eight cases) and loss of CFA 14 (five cases). Cytogenetic and histopathological data for each case are presented, and cytogenetic similarities with human non-Hodgkin's lymphoma are discussed. We have also assembled a panel of 41 canine chromosome-specific BAC probes that may be used for accurate and efficient chromosome identification in future studies of this nature.

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“…Early investigations using reciprocal chromosome paint studies showed that dogs and humans shared large syntenic blocks of DNA and as many as 65À70 blocks initially were detected (Breen et al, 1999;Yang et al, 1999;Sargan et al, 2000). Radiation hybrid mapping expanded that number to over 85 (Guyon et al, 2003).…”

Section: The Syntenic Dogmentioning

confidence: 99%