A competitive marathon race decreases neutrophil functions in athletes

Chinda, Daisuke; Nakaji, Shigeyuki; Umeda, Takashi; Shimoyama, Tadashi; Kurakake, Shigeyoshi; Okamura, Noriyoshi; Kumae, Takashi; Sugawara, Kazuo

doi:10.1002/bio.744

Cited by 48 publications

(68 citation statements)

References 30 publications

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“…However, under the conditions of severe and prolonged exercise such as a full marathon and a training camp plus weight reduction, neutrophil parameters have tended to deviate from such typical compensatory changes. For example, in some reports both PA and ROS decreased (22,28).…”

Section: Discussionmentioning

confidence: 96%

Effects of 2.5‐hour sumo training on serum opsonic activity

et al. 2009

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Sumo is a traditional Japanese sport, but the effect of actual daily training on neutrophil function is unknown. We evaluated the effect of sumo training on serum opsonic activity (SOA), which is one of the main neutrophil-related functions. Seventeen male university sumo wrestlers participated in the study. Changes in anthropometric parameters, concentrations of serum immunoglobulins (IgG, IgA and IgM), complements (C3 and C4), myogenic enzymes (lactate dehydrogenase, asparate aminotransferase, alanine aminotransferase and creatine kinase), white blood cell/neutrophil counts and SOA were measured immediately before and after actual daily training for 2.5 h. Compared with the pre-values, immunoglobulins and complements, myogenic enzymes and white blood cell/neutrophil counts significantly increased (p < 0.01 for all). As for SOA, the values of the peak height and the area under the curve significantly increased after the training when assessed using lucigenin as a chemiluminigenic probe (p < 0.01 for all), but showed no significant change when luminol was used as the chemiluminigenic probe. In conclusion, daily actual sumo training for 2.5 h increases SOA, thus possibly activating the reactive oxygen species production of neutrophils.

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Section: Discussionmentioning

confidence: 96%

Effects of 2.5‐hour sumo training on serum opsonic activity

et al. 2009

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“…the neutrophil ROS production capability, phagocytic activity (PA) and serum opsonic activity (SOA), have demonstrated a variety of results after acute/single bout exercise. ROS production has been reported to increase (8)(9)(10)(11)(12), decrease (3,10,11,(13)(14)(15) and show no change (13,14,(17)(18)(19). PA significantly decreased after intense exercise (3,(10)(11)(12)(19)(20)(21) or increased or did not change with exercise (10,11,13,16,22).…”

Section: Introductionmentioning

confidence: 91%

“…High-intensity exercise, frequent training sessions and strenuous participation in athletes outwith the sumo field have all been reported to increase the tendency of the athletes involved to catch cold (1,2) and have induced the 'over-training syndrome' . One reason for this is that the non-specific immune system, particularly neutrophil immune functions including their reactive oxygen species (ROS) production capability, is suppressed by such intense training exercise (3).…”

Section: Introductionmentioning

confidence: 99%

Effects of a bout of traditional and original sumo training on neutrophil immune function in amateur university sumo wrestlers

Umeda¹,

Saito²,

Matsuzaka³

et al. 2008

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In order to examine in detail the influence on the neutrophil immune function in sumo wrestlers of performing traditional and original training we examined changes in the neutrophil immune function in 17 male amateur university sumo wrestlers (aged 20.2 +/- 1.5 years), before ('Pre') and after the training ('Post') for 2.5 h under fasting conditions. Assays included blood leukocyte and neutrophil counts, serum concentration of immunoglobulins, complements, myogenic enzymes and neutrophil oxidative burst activity (OBA) and phagocytic activity (PA). Myogenic enzymes, neutrophil counts, the ratio of neutrophil counts:leukocyte counts significantly increased and immunoglobulins and complements decreased in Post compared with Pre. There was a positive correlation between the change of neutrophil counts before and after the training and the change of creatine kinase (r = 0.667, p < 0.01). The Post OBA significantly increased and PA significantly decreased compared with Pre. It was concluded that sumo training causes muscular damage and an increase in the neutrophil count as a response. In this time, although OBA increased, PA decreased after training. Compensation between PA and reactive oxygen species production may exist to maintain the overall integrity of the neutrophil immune function.

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“…the neutrophil ROS production capability, PA and SOA, have demonstrated a variety of results after acute/single bout exercise. ROS production has been reported to increase (1,(8)(9)(10)(11), decrease (1,10,(12)(13)(14)(15)(16) and remain unchanged (13,(17)(18)(19). PA significantly decreased after intense exercise (1,10,11,16,(19)(20)(21) or increased, or did not change with exercise (1,10,12,15,22).…”

Section: Introductionmentioning

confidence: 91%

The effects of a two‐hour judo training session on the neutrophil immune functions in university judoists

et al. 2008

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The present study examined the effects of judo training on neutrophil and related functions. We measured and studied changes in the neutrophil and its related functions in 22 male university judoists immediately before (Pre values) and immediately after (Post values) a 2 h training session: reactive oxygen species (ROS) production capability, phagocytic activities (PA) and serum opsonic activity (SOA). Neutrophil count in whole blood, myogenic enzymes (creatine kinase, lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase), immunoglobulins (IgG, IgA and IgM) and complements (C3 and C4) in serum were also measured. The Post values of the neutrophil count, myogenic enzymes and IgG increased significantly compared with the Pre values. ROS production capability and SOA also significantly increased following training, although PA showed a slight decrease (but not statistically significant). Taking the findings of our previous studies into consideration, three major neutrophil or related functions, namely ROS production capability, PA and SOA, might compensate for each other to maintain the overall integrity of the neutrophil immune function, in that ROS and SOA increased to compensate for the slight decrease in PA, or PA slightly decreased to compensate for the increase in ROA and SOA after exercise.

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A competitive marathon race decreases neutrophil functions in athletes

Cited by 48 publications

References 30 publications

Effects of 2.5‐hour sumo training on serum opsonic activity

Effects of 2.5‐hour sumo training on serum opsonic activity

Effects of a bout of traditional and original sumo training on neutrophil immune function in amateur university sumo wrestlers

The effects of a two‐hour judo training session on the neutrophil immune functions in university judoists

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