A competing endogenous RNA network reveals key lncRNAs associated with sepsis

Abstract

The initial definitions, that sepsis is caused by a host's systemic inflammatory response syndrome (SIRS) to infection,

LINC00963 May Be Associated with a Poor Prognosis in Patients with Cervical Cancer

“…The results showed that reactome biological oxidations, inflammasomes, cytokine-cytokine receptor interaction, toll-like receptor signaling pathway, JAK/STAT signaling pathway, and NF-κB activation were differentially enriched in the high-expression LINC00963 phenotype of CESC. Furthermore, LINC00963 could be associated with cellular function, such as biological oxidations and inflammasomes, in addition to immune regulation and cancer progression [ 21 – 23 ]. Protective immune toll-like receptors can induce the secretion of inflammatory cytokines and induce lymphocytes to mediate an adaptive antigen-specific immune response for eliminating invasive microorganisms [ 24 ].…”

The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction

“…A recent study using microarray and whole genomic transcription sequencing with bioinformatics analyses on blood samples from patients with sepsis discovered 46 differentially expressed lncRNAs (DElncRNAs) ( 21 ). Additionally, 28 upregulated and 61 downregulated lncRNAs were identified in the public reported NCBI GEO dataset ( 22 ).…”

“…As previously discussed, numerous lncRNAs are aberrantly expressed in SICD compared with normal cardiac tissue or cell lines, and this is useful to distinguish SICD patients from healthy cohorts. Although nearly all lncRNAs with direct evidence of their involvement in SICD were declared as potential biomarkers of SICD, those lncRNAs also show aberrant expression patterns in sepsis without cardiac dysfunction, especially critical patients, and in other non-sepsis situations such as MI, I/R, and acute kidney injury ( 21 , 22 , 24 , 26 , 110 , 114 , 148 ). This reduces the reliability of using these lncRNAs as potential biomarkers of SICD.…”