Globally, osteoporosis is considered a widespread metabolic bone disease, vertebral fractures being probably one of the most common clinical manifestations encountered in osteoporotic patients. Non-pharmacologic therapies of osteoporosis include, among others, the use of different types of orthoses, such as spinal orthoses or hip protectors. To date there is a limited number of studies that evaluate the efficacy of spinal orthoses and hip protectors used in osteoporotic patients, therefore providing insufficient information to clinicians regarding these aspects. This article reviewed the use and efficacy of the most commonly prescribed spinal orthoses and hip protectors in osteoporotic patients. According to a significant number of studies, modern spinal orthoses proved to be effective in the management of vertebral fractures in osteoporotic patients. However, the efficacy of hip protectors in reducing the impact of falls onto the hip and preventing hip fractures still seems to be controversial. Osteoporosis is a condition that should be treated using a comprehensive approach that includes both pharmacological and non-pharmacological treatment options. Orthoses, such as modern spinal orthoses or back braces and hip protectors might represent an efficacious nonpharmacological option in the management of osteoporotic vertebral or hip fractures.