A comparison study of metformin only therapy and metformin combined with Chinese medicine jianyutangkang therapy in patients with type 2 diabetes: A randomized placebo-controlled double-blind study

Hu, Yuan; Zhou, Xin; Liu, Ping; Wang, Bo; Duan, Dongmei; Guo, Dai-Hong

doi:10.1016/j.ctim.2015.11.005

Cited by 24 publications

(34 citation statements)

References 30 publications

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“…In diabetes patients, TCM herbs such as Rhizoma Coptidis, Radix Rehmanniae Recens, Radix Ginseng, Radix Puerariae, Radix Astragali seu Hedysari, Radix Bupleuri, Radix et Rhizoma Rhei, Radix Scutellariae, Radix Trichosanthis, Fructus Mume and Rhizoma Anemarrhenae have been shown to effectively lower blood glucose and improve clinical outcomes. We assessed 12 RCTs that focused on TCM and diabetes and had the following Jadad scores: 7 (six reports), 6 (one report), 5 (four reports) and 4 (one report). Sample sizes ranged from 79 to 800, and follow‐up duration ranged from 12 to 48 weeks.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, the combined administration of Jianyutangkang tablets with metformin for 26 weeks significantly reduced HbA1c levels compared with metformin monotherapy applied over the same period (0.8% vs 0.6%, respectively; P < .05). Treatment with Jianyutangkang and metformin also improved lipid profiles compared with metformin monotherapy ( P < .05) . In a double‐blind, parallel‐group RCT, patients with diabetes were randomly assigned to receive treatment with Tianqi or placebo when they exhibited poor glucose control under metformin treatment alone.…”

Section: Resultsmentioning

confidence: 99%

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Evidence and potential mechanisms of traditional Chinese medicine for the treatment of type 2 diabetes: A systematic review and meta‐analysis

Tian

Jin

Bao

et al. 2019

Diabetes Obesity Metabolism

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Traditional Chinese medicine (TCM) has recorded knowledge of diabetes for over 2000 years. Because a considerable number of TCM studies exhibit design defects, such as limited intervention duration, small sample sizes and inconsistent efficacy evaluations, the role of TCM in the treatment of diabetes cannot be fully elucidated. In this review, we evaluate randomized controlled trials of prediabetes, diabetes and diabetic complications published in the past decade. We found that TCM could significantly improve glucose control and clinical indices in patients with diabetes and effectively delay the progression of diabetes. We also summarize potential pharmacological mechanisms underlying the efficacy of TCM medication/herbs and their active ingredients for treating diabetes. More rigorously designed experiments and long-term evaluation of TCM for diabetes will allow for more effective diabetes management. K E Y W O R D S diabetes, diabetic complications, pharmacological mechanisms, prediabetes, randomized controlled trials, traditional Chinese medicine 1 | INTRODUCTION The overall population of patients with diabetes has reached approximately 415 million and is estimated to rise further to nearly 642 million by 2040. 1 Vast amounts of medical resources are spent on diabetes, and the total global health expenditure because of diabetes was estimated to be $673 billion in 2015; however, a decrease in the incidence of diabetes has not been observed. 1,2 About 5 million deaths are attributed to diabetes each year, and patients with an extended duration of complications lose their ability to work, thereby causing heavy social and economic burdens. Therefore, it is urgent to develop effective strategies to prevent the global health threat of diabetes. Traditional Chinese medicine (TCM) has focused on the treatment of diabetes for thousands of years. The "whole view" and "multi-targets" approaches of TCM provide unique advantages in controlling complex diseases such as diabetes. 3 TCM focuses on individualized treatments that are based on the differentiation of syndromes, control of balance and various routes of administration. 4,5 In recent years, large-scale clinical trials have confirmed that TCM has made progress in controlling blood glucose levels. Additionally, the application of modern science and technology has helped to uncover some of the therapeutic mechanisms underlying TCM's potency. Studies have been conducted to *Jiaxing Tian, De Jin and Fengmei Lian contributed equally to this study. Fengmei Lian and Xiaolin Tong are co-corresponding authors.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Evidence and potential mechanisms of traditional Chinese medicine for the treatment of type 2 diabetes: A systematic review and meta‐analysis

Tian

Jin

Bao

et al. 2019

Diabetes Obesity Metabolism

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“…The pooled analyses indicated that Tangminling pill was more efficacious in decreasing glucose level, body weight, and improving β-cell function, with no more drug-related adverse events, than placebo treatment in T2DM patients. Traditional Chinese medications, mainly edible herbs, have been widely used in clinical practice in China for more than 2000 years [16][17][18] (Table 3). Three bioactive alkaloids have been isolated from Rhizoma coptidis, including berberine, coptisine, and jatrorrhizine.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of traditional Chinese medication Tangminling pill in Chinese patients with type 2 diabetes

et al. 2019

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The morbidity of type 2 diabetes mellitus (T2DM) has been increasing rapidly worldwide. Tangminling pill, consisting of ten Chinese herbal medications, is usually prescribed for T2DM in mainland China. Whether treatment with Tangminling can improve clinical outcomes of T2DM patients was still debated. Four studies comparing Tangminling vs. placebo treatment in T2DM patients were included and 767 T2DM patients were enrolled in our analyses. Tangminling treatment exhibited better efficacy than placebo in reducing hemoglobin A1c (HbA1c) (1.11 vs. 0.32%; pooled weighted mean difference [WMD]: 0.80; 95% confidence interval [CI]: 0.65–0.96; P<0.001), fasting plasma glucose (0.82 vs. −0.40 mM; WMD: 1.10; 95% CI: 0.56–1.64; P<0.001), 2-h postprandial glucose (2-hr PG) (2.81 vs. 1.11 mM; WMD: 1.80; 95% CI: 1.72–1.88; P<0.001), homeostatic model assessment-β level (4.28 vs. 0.41; WMD: 0.44; 95% CI: 0.27–0.61; P<0.001), waist circumference (WC) (1.04 vs. 0.36 cm; WMD: 0.78; 95% CI: 0.37–1.19; P<0.001) and body weight index (0.37 vs. 0.11 kg/m2; WMD: 0.30; 95% CI: −0.00 to 0.61; P=0.05). Tangminling pill might reduce glucose level and body weight and improve β-cell function in T2DM patients. Our study highlights the important role of Tangminling pill in the management of T2DM.

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“…Herbal remedies and acupuncture could prove to be effective alternative and adjunctive treatments for diabetes. Recent clinical trials using herbal medicine (11,12) and acupuncture (13,14) have reported possible therapeutic value in diabetes, although these results are unreliable due to small sample sizes and low-quality methodologies.…”

Section: Introductionmentioning

confidence: 99%

Herbal acupuncture for type 2 diabetes: A meta-analysis

Lee

Nam

Lee

2017

Experimental and Therapeutic Medicine

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Herbal acupuncture (HA) is a modern adjunctive technique in which natural herbs or biologic substances are injected into acupuncture points. The objective of this systematic review was to evaluate evidence of the effectiveness of HA for type 2 diabetes mellitus (T2DM). Three databases were searched. The included randomized controlled trials (RCTs) evaluated HA in controls and patients with T2DM and reported at least one of the following: Fasting blood glucose (FBG), postprandial (PP2hr) glucose and glycated hemoglobin (HbA1c). In a meta-analysis of seven RCTs (n=598 patients), HA significantly reduced levels of FBG, PP2hr glucose and HbA1c (P<0.0001, P=0.0005 and P=0.004, respectively). There was no significant effect of HA on total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, or triglyceride level. High degrees of heterogeneity were present for all analyses except HDL-cholesterol and LDL-cholesterol. HA might have a beneficial effect on FBG, PP2hr glucose and HbA1c levels in patients with T2DM; however, because of several limitations, the results are inconclusive. Therefore, additional rigorous RCTs are warranted to overcome the limitations of previous studies.

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A comparison study of metformin only therapy and metformin combined with Chinese medicine jianyutangkang therapy in patients with type 2 diabetes: A randomized placebo-controlled double-blind study

Cited by 24 publications

References 30 publications

Evidence and potential mechanisms of traditional Chinese medicine for the treatment of type 2 diabetes: A systematic review and meta‐analysis

Evidence and potential mechanisms of traditional Chinese medicine for the treatment of type 2 diabetes: A systematic review and meta‐analysis

Efficacy of traditional Chinese medication Tangminling pill in Chinese patients with type 2 diabetes

Herbal acupuncture for type 2 diabetes: A meta-analysis

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