A comparison study of haemolysis production in three contemporary centrifugal pumps

Abstract

One challenge in providing extracorporeal circulation is to supply optimal flow while minimising adverse effects, such as haemolysis. To determine if the recent generation constrained vortex pumps with their inherent design improvements would lead to reduced red cell trauma, we undertook a study comparing three devices. Utilizing a simulated short-term ventricular assist circuit primed with whole human blood, we examined changes in plasma free haemoglobin values over a six-day period. The three pumps investigated were the Maquet Rotaflow, the Levitronix PediVAS and the Medos Deltastream DP3.This study demonstrated that all three pumps produced low levels of haemolysis and are suitable for use in a clinical environment. The Levitronix PediVAS was significantly less haemolytic than either the Rotaflow (p<0.05) or the DP3 (p<0.05). There was no significant difference in plasma free haemoglobin between the Rotaflow and the DP3 (p=0.71).

Pediatric Extracorporeal Life Support Using a Third Generation Diagonal Pump

“…14 Rotary pumps are either axial or centrifugal pumps, and diagonal pumps are a combination of both technologies. 15 The Deltastream diagonal pump (DP3; Medos Medizintechnik AG, Heilbronn, Germany) is the third generation of a diagonal rotational pump which has undergone significant changes in design and handling. The metal shaft and sealing ring have been removed from the magnetically coupled pump head.…”

“…Heat generation is prevented by less shear stress from the bearing, resulting in less blood trauma. 15 The minimal priming volume is 16 ml [16][17][18] and, like the DP1, 13 pump settings are able to create a pulsatile flow. 15,17 The ideal working range is between 2,000 and 8,000 unit/min, achieving flow ranges between 0 and 7 L/min.…”

Extracorporeal techniques in acute respiratory distress syndrome

“…Additionally, a number of advances have been made over time in extracorporeal technology, including the use of centrifugal pumps, polymethylpentene membranes, biocompatible circuit components, and improvements in cannula technology (26,27).…”

Extracorporeal Circulatory Approaches to Treat Acute Respiratory Distress Syndrome

“…[21][22][23][24][25][26][27][28][29] More recently, there have been significant advances in extracorporeal technology, including the use of centrifugal pumps, polymethylpentene oxygenators, biocompatible circuit components, and single-site dual-lumen cannulae. 10,30 In the era of modern extracorporeal circuitry, a resurgence of interest accompanied reports of success using ECMO for patients with severe ARDS during the 2009 influenza A (H1N1) pandemic, most notably the 75% survival among a subset of patients in Australia and New Zealand with a median partial pressure of arterial oxygen (PaO 2 ) to fraction of inspired oxygen (FiO 2 ) ratio of 56. [31][32][33][34][35] However, comparable rates of survival among patients with H1N1-related ARDS and similar degrees of hypoxemia (median PaO 2 /FiO 2 ratio of 61) were observed at a center whose management strategy did not include ECMO.…”