A Comparison Study of Fiber Diameter's Effect on Characteristic Features of Donepezil/Curcumin‐Loaded Polycaprolactone/Polylactic Acid Nanofibers

Abstract

Nanofibers (NFs) offer an alternative option for the treatment of Alzheimer's disease (AD) by addressing unmet clinical problems. In this study, anti‐AD drugs, donepezil (DO) and curcumin (CUR), are loaded in polylactic acid/polycaprolactone NFs. The effect of fiber diameter on drug release behavior is mainly observed, and the successful loading of DO and CUR to NFs is demonstrated. The tensile strength of DO/CUR‐loaded NFs (DNFs) with lower fiber diameter is found to be higher. The working temperature is increased by the decrease of glass transition temperature and increase of the melting temperature after loading drugs. Furthermore, the increase in the percentage of swelling and decrease in the degradation rate for NFs are observed due to the increase of fiber diameter. Encapsulation efficiency and burst release percentages for DNFs are augmented by the increase of fiber diameter. Nevertheless, DNFs exhibit a sustained drug release manner over 2 weeks. NFs do not demonstrate a toxic effect on L929 (mouse fibroblast) cells, and additionally, they promote cell proliferation. Considering all these results, it is proven that the fiber diameter affects all characteristic features of NFs, and DNFs lead to a new and promising drug delivery system for the treatment of AD.

Design of Cinnamaldehyde- and Gentamicin-Loaded Double-Layer Corneal Nanofiber Patches with Antibiofilm and Antimicrobial Effects

“…Although PVA/GEL/CA/GEN nanofiber patch exhibited a swelling profile until the end of the 5th day, it was noticeable that it started to degrade after 5 days, similar to the other nanofiber groups. Aydin et al demonstrated that an increase in fiber diameter may cause an increase in swelling behavior . The higher swelling ratio of the PVA/GEL/CA/GEN nanofiber patches compared to the other groups may be associated with the higher diameter of the fibers.…”

“…Aydin et al demonstrated that an increase in fiber diameter may cause an increase in swelling behavior. 45 The higher swelling ratio of the PVA/GEL/CA/GEN nanofiber patches compared to the other groups may be associated with the higher diameter of the fibers. Structures exposed to PBS deteriorate over time lose their weight as they begin to dissolve in PBS.…”

The production of curcumin-loaded PLGA/PEG nanoparticle for the treatment of Alzheimer’s disease

“…The stretching of the C-O group was obtained at 1083 cm -1 [21,22]. The characteristic peaks of CUR were analyzed and the O-H stretching vibration belonging to the phenol group at 3232 cm -1 , -CH3 stretching vibration at 2906 cm -1 , C-O stretching vibration at 1024 cm -1 , bands of C=O and C-O (ether) groups at 1625 and 1589 cm -1 , -C-O elongation of OH single bond group at 1500-1400 cm -1 , specific peaks of C-H alkene group and C-H bending vibration at 700, 806 and 960 cm -1 were observed [23,24]. Considering all these characteristic peaks, the peaks at 2940, 1643, 1461, 1421, 1286, and 892 cm -1 were found compatible with the characteristic peaks of PLGA and PEG after analyzing of PNP.…”

Improvement in the Sustained-Release Performance of Electrospun Zein Nanofibers via Crosslinking Using Glutaraldehyde Vapors

“…The EU contents in the zein nanofiber samples were determined according to the method of Aydin et al (2022), with some modifications [48]. In brief, each nanofiber sample (15 mg) was placed in a dialysis bag containing 4 mL of ethanol aqueous solution (90%, v/v).…”