A comparison study of clinician-rated atopic dermatitis outcome measures for intermediate- to dark-skinned patients

Abstract

EASI showed excellent reliability for patients of all skin colours, and is recommended as the optimal core measure for patients with all skin colours.

Lupus community panel proposals for optimising clinical trials: 2018

“…Studies in other skin diseases have found that skin type has not altered the perception of colour in trained raters. 126 Severe erythema can rarely result in haemorrhagic crusting, and this is captured as an indication of severe activity. Evanescent erythema is a problem with any type of skin assessment.…”

Comparison of patient (POEM), observer (EASI, SASSAD, TIS) and corneometry measures of emollient effectiveness in children with eczema: findings from the COMET feasibility trial

“…Many different patient‐ and clinician‐reported measures have been variously compared in other studies, but few published papers have compared the eczema severity measures presented here. EASI was found to be correlated with SASSAD ( r = 0·86) in one study of 50 Korean children, while SASSAD, EASI and TIS and POEM and EASI have recently been compared in two small studies (12 and 25 participants, respectively) of patients (nine and 13 children, respectively) with moderate or worse eczema. Good inter‐rater reliability was reported for EASI and SASSAD but not for TIS; however, excellent intra‐rater reliability for EASI and TIS and good intra‐rater reliability for SASSAD were found.…”

“…Many different patient-and clinician-reported measures have been variously compared in other studies, but few published papers have compared the eczema severity measures presented here. EASI was found to be correlated with SASSAD (r = 0Á86) in one study of 50 Korean children, 20 while SAS-SAD, EASI and TIS 21 and POEM and EASI 22 have recently been compared in two small studies (12 and 25 participants, respectively) of patients (nine and 13 children, respectively) with moderate or worse eczema. Good inter-rater reliability Corneometry antecubital fossa 0Á02 (À0Á09-0Á13); 0Á71 0Á16 (0Á05-0Á27); 0Á003 0Á13 (0Á02-0Á23); 0Á017 À0Á03 (À0Á14-0Á08); 0Á59 1 Corneometry forearm 0Á09 (À0Á02-0Á20); 0Á11 0Á09 (À0Á02-0Á20); 0Á091 0Á11 (0Á00-0Á23); 0Á044 0Á10 (À0Á01-0Á20); 0Á070 0Á35 (0Á25-0Á45); < 0Á001 1 PGA 0Á40 (0Á31-0Á49); < 0Á001 0Á33 (0Á24-0Á41); < 0Á001 0Á37 (0Á29-0Á46); < 0Á001 0Á24 (0Á15-0Á33); < 0Á001 0Á04 (À0Á07-0Á15); 0Á49 0Á03 (À0Á08-0Á14); 0Á61 1…”

Dermatological evaluation in patients with skin of colour: the effect of erythema on outcome measures in atopic dermatitis

“…Prior studies argue that cutaneous diseases that traditionally rely on the detection of erythema for diagnosis and severity, such as atopic dermatitis, may be underdiagnosed and undertreated in patients with SOC . In this edition of the British Journal of Dermatology , Zhao and colleagues present an outstanding comparison study addressing the validity of outcome measures in patients with SOC with atopic dermatitis . In contrast to current hypotheses, the presence of erythema did not worsen intra‐ or inter‐rater reliability among experienced dermatologists using several atopic dermatitis outcome measures in patients with SOC.…”