This research paper presents a guideline on how to select between self-contained electro-hydraulic and electromechanical cylinders. An example based on the motion control of a single-boom crane is studied. The sizing process of the different off-the-shelf components is analyzed in terms of design impact when replacing a traditional valve-controlled hydraulic cylinder. The self-contained electro-hydraulic solution is the best choice when there exists a risk for high impact forces, when the required output power is continuously above 2 kW, or when installation space, weight, and cost are critical design objectives. However, the electro-mechanical solution is expected to show better controllability due to the higher drive stiffness, requires less control effort, has higher energy efficiency, and lower system complexity resulting in a more straightforward design approach.