A comparison on the metabolic profiling of the Mexican anxiolytic and sedative plant Galphimia glauca four years later

Sharma, Ashutosh; Cardoso-Taketa, Alexandre; Choi, Young Hae; Verpoorte, Robert; Villarreal, Marı́a Luisa

doi:10.1016/j.jep.2012.03.033

Cited by 28 publications

(41 citation statements)

References 13 publications

(11 reference statements)

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“…Our two previous metabolic profiling studies of Galphimiaglauca using 1 H-NMR spectroscopy and multivariate data analysis, clearly showed differences in metabolic profiles of Galphimiaglauca populations in levels of sedative, anxiolytic and anti-inflammatory activities that were clearly related to the region of collection (Cardoso-Taketa et al, 2008; Sharma et al, 2012). Two of the populations (GM and QJ) were particularly high in galphimines (active populations), whereas all of the other populations (MM, MT, MC, JG and CT) did not seem to have detectable levels of these secondary metabolites.…”

Section: Introductionmentioning

confidence: 75%

“…In a clinical study performed with subjects exhibiting symptoms of general anxiety, standardized preparations of Galphimiaglauca , administered to the patients produced anxiolytic effects (Herrera-Arellano et al, 2007). This plant has also been found to produce other pharmacological effects, including anti-inflammatory, anti-malaric, anti-allergic and anti-asthmatic activities (Diaz, 1976; Dorsch et al, 1992; Neszmelyi et al, 1993; Camacho, 1997; Sharma et al, 2012). Galphimiaglauca has been commercialized internationally and made available in several online herbal drug stores.…”

Section: Introductionmentioning

confidence: 99%

“…Two of the populations (GM and QJ) were particularly high in galphimines (active populations), whereas all of the other populations (MM, MT, MC, JG and CT) did not seem to have detectable levels of these secondary metabolites. Interestingly, the anti-inflammatory activity was found to be high in all populations (Sharma et al, 2012). The presence of galphimines in the GM and QJ populations and the absence in the MM, MT, MC, JG and CT samples, has also been confirmed via high-performance liquid chromatography (HPLC) analysis.…”

Section: Introductionmentioning

confidence: 99%

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DNA barcoding of the Mexican sedative and anxiolytic plant Galphimia glauca

Sharma

Folch

Cardoso-Taketa

et al. 2012

Journal of Ethnopharmacology

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Ethnopharmacology relevance Galphimiaglauca (Malpighiaceae) is a Mexican plant popularly used as a tranquilizer in the treatment of nervous system disorders, although it is also used to treat other common illnesses. Aim of the study The aim of this investigation is to find out if populations of Galphimiaglauca collected in different regions and ecosystems in Mexico actually belong to the same species by using the contemporary technique of DNA barcodes. Our previous metabolic profiling study demonstrates that different collections of this plant obtained from various geographical areas exhibited diverse chemical profiles in terms of the active compounds named Galphimines. We expected the DNA barcodes apart from indicating the different species of Galphimia would indicate the active populations. Materials and methods We employed matK, rpoC1 and rbcL DNA barcodes to indicate the different species. Furthermore to investigate the possible impact of the several different ecosystems where the seven populations were collected, thin layer chromatography was employed to create a partial chemical profile, which was then compared with the metabolic profiles obtained by 1H-NMR and multivariate data analysis. Results and conclusions This study showed that the seven populations here analyzed contain at least three different species of the genus Galphimia, although each individual population is homogeneous. Interestingly our TLC analysis clearly showed that the active populations displayed a distinctively unique chemical profile. This work also showed that the use of DNA barcodes combined with chemical profile analysis is an excellent approach to solve the problems of quality control in the development of Galphimia-based medicines, as well as for any breeding programs for this species.

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Section: Introductionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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DNA barcoding of the Mexican sedative and anxiolytic plant Galphimia glauca

Sharma

Folch

Cardoso-Taketa

et al. 2012

Journal of Ethnopharmacology

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“…The HPLC-PCA map was used to determine the quality of the data as well as discern different HPLC peaks between extracts that may account for the antimicrobial activity. This technique has been previously used to group plants based on their chemical profiles in order to determine compounds that contributed to pharmacological activity (Li et al, 2012;Sharma et al, 2012). The loading plot (not shown) confirmed that the differences in activity of the 75% ethanol extract and root decoction were due to the major peaks seen in the first five minutes at 210 nm .…”

Section: Discussionmentioning

confidence: 67%

Antimicrobial assays of three native British plants used in Anglo-Saxon medicine for wound healing formulations in 10th century England

Watkins

Pendry

Medina

et al. 2012

Journal of Ethnopharmacology

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Ethnopharmacological relevance: Three important Anglo-Saxon medical texts from the 10 th century contain herbal formulations for over 250 plant species, many of which have yet to be evaluated for their phytochemical and/or pharmacological properties. In this study, three native British plants were selected to determine antimicrobial activity relevant to treating bacterial infections and wounds. represented 87% of the dataset variance. The P. reptans 75% ethanol root extract exhibited the greatest range of activity with MIC 50 at 31.25 µg/mL to a total MIC that was also the minimum bactericidal concentration (MBC) at 1 mg/mL. Additionally, the root of P. reptans inhibited growth of Gram-negative bacteria with the 75% ethanol extract having a MIC 50 at 1 mg/mL against Pseudomonas aeruginosa and the decoction a MIC 50 at 3.9 µg/mL against Escherichia coli. Journal of Ethnopharmacology

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“…The branches and seeds of Galphimia glauca Cav are used for the treatment of nervous excitement [16] and it is the most studied species for the treatment of anxiety in Mexico [17,18]. An active compound, a norsecotriterpene named galphimine-B, which also shows a sedative activity [19].…”

Section: Discussionmentioning

confidence: 99%

Mexican Medicinal Plants Used to Alleviate the Symptoms of Anxiety: Mini-Review

Soriano-Garcı́a¹,

E²,

Mr³

2017

JAPLR

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Anxiety is considered together with depression the most dangerous mental psychiatric disorders worldwide. In Mexico, the use of medicinal plants is growing very rapidly in the treatment of these disorders. It is very important to point out that the lack of scientific evidence to validate this is necessary to have the clinical evidence in order to support their use of these plants. This work deals with their identification of plants, to review the current preclinical and when the clinical information is available to present current status of these plants is use to alleviate the symptoms of anxiety.

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A comparison on the metabolic profiling of the Mexican anxiolytic and sedative plant Galphimia glauca four years later

Cited by 28 publications

References 13 publications

DNA barcoding of the Mexican sedative and anxiolytic plant Galphimia glauca

DNA barcoding of the Mexican sedative and anxiolytic plant Galphimia glauca

Antimicrobial assays of three native British plants used in Anglo-Saxon medicine for wound healing formulations in 10th century England

Mexican Medicinal Plants Used to Alleviate the Symptoms of Anxiety: Mini-Review

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