A comparison of α-methylnorepinephrine, vasopressin and epinephrine for cardiac resuscitation

Klouche, Kada; Weil, Max Harry; Sun, Shijie; Tang, Wanchun; Zhao, Dan Hong

doi:10.1016/s0300-9572(02)00403-3

Cited by 34 publications

(12 citation statements)

References 36 publications

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“…On the contrary, in asphyxial CA, it seems that prompt reversal of asphyxiation prior to cardiac standstill results in complete neurologic recovery, whereas after pulselessness permanent brain injury and deficit can develop even after few minutes [38][39][40][41].…”

Section: Differences In Brain Injurymentioning

confidence: 99%

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The pathophysiologies of asphyxial vs dysrhythmic cardiac arrest: implications for resuscitation and post-event management

Varvarousis

Varvarousi

Iacovidou

et al. 2015

The American Journal of Emergency Medicine

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Section: Differences In Brain Injurymentioning

confidence: 99%

“…Both injuries demonstrate selective vulnerability of brain regions, as the hippocampus, the reticular thalamus, the cerebellum, and neocortex [38,[40][41][42]. Characteristic ischemic lesions include shrunken injured neurons, with eosinophilic cytoplasm and pycnotic or absent nuclei [39,43].…”

Section: Differences In Brain Injurymentioning

confidence: 99%

The pathophysiologies of asphyxial vs dysrhythmic cardiac arrest: implications for resuscitation and post-event management

Varvarousis

Varvarousi

Iacovidou

et al. 2015

The American Journal of Emergency Medicine

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“…However, in the remainder, adrenaline only increased the CPP by 3 AE 2 mmHg and subsequent doses had minimal effect on CPP. Klouche et al [36] used various drugs in 20 rats after VF arrest and found that adrenaline impaired post-resuscitation myocardial function more than vasopressin and a selective alpha-agonist, and this function was similar to saline-placebo controls. However, survival was superior with adrenaline than with controls.…”

Section: Administration Of Adrenaline (Epinephrine)mentioning

confidence: 99%

Guideline for resuscitation in cardiac arrest after cardiac surgery

Dunning

Fabbri

Kolh³

et al. 2009

European Journal of Cardio-Thoracic Surgery

153

120

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The Clinical Guidelines Committee of the European Association for Cardio-Thoracic Surgery provides this professional view on resuscitation in cardiac arrest after cardiac surgery. This document was created using a multimodal methodology for evidence generation including the extrapolation of existing guidelines from the International Liaison Committee on Resuscitation where possible, our own structured literature reviews on issues particular to cardiac surgery, an international survey on resuscitation hosted by CTSNet and manikin simulations of potential protocols. This protocol differs from existing generic guidelines in a number of areas, the most import of which are the following: successful treatment of cardiac arrest after cardiac surgery is a multi-practitioner activity with six key roles that should be allocated and rehearsed on a regular basis; in ventricular fibrillation, three sequential attempts at defibrillation (where immediately available) should precede external cardiac massage; in asystole or extreme bradycardia, pacing (where immediately available) should precede external cardiac massage; where the above measures fail, and in pulseless electrical activity, early resternotomy is advocated; adrenaline should not be routinely given; protocols for excluding reversible airway and breathing complications and for safe emergency resternotomy are given. This guideline is subject to continuous informal review, and when new evidence becomes available.

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“…Despite its widespread use, a large body of experimental evidence from animal studies suggests that adrenaline may have no effect or even a detrimental effect on various measures of well-being and survival during resuscitation (Brown et al 1988;Wenzel et al 1999;Klouche et al 2003;Niemann and Garner 2005;Schwartz and Lagranha 2006) . High doses do not seem to improve survival and may increase adverse effects (Ditchey and Lindenfeld 1988;Lindner et al 1991b;Lindner et al 1991a;Hornchen et al 1993;Hilwig et al 2000;Voelckel et al 2000).…”

Section: Rationale For the Use Of Adrenaline In Cprmentioning

confidence: 99%

“…Various species have been used including rats (Klouche et al 2003;Kolarova et al 2005), dogs (Roberts et al 1990) and pigs (Pellis et al 2003;Niemann and Garner 2005). There is a wide distribution in the extent of coronary collateral circulation between species, meaning that selection of an appropriate species is essential.…”

Section: In Vivo Experimentsmentioning

confidence: 99%