A comparison of wound healing between a skin protectant ointment and a medical device topical emulsion after laser resurfacing of the perioral area

Efficacy of MAS063DP lotion vs 0.02% triamcinolone acetonide lotion in improving post‐ablative fractional CO2 laser resurfacing wound healing: a split‐face, triple‐blinded, randomized, controlled trial

“…The wound healing process from AFL skin resurfacing usually lasts less than 1 week . In this study, the erythema, edema, and scale significantly improved on day 5 in both groups following the clinical and biometric evaluations, without statistical significance between the two treatment groups.…”

“…AFL resurfacing, especially the fractional ablative CO 2 laser, is an effective treatment for acne scar and other dermatologic conditions like wrinkles, photo aging, and laser‐assisted drug‐delivery system. The microthermal damage zone caused by AFL treatment to keratinocyte and/or melanocyte has been assumed to increase inflammation during the wound healing process, resulting in the delayed wound healing and prolonged erythema, dyspigmentation, scarring, herpes simplex virus reactivation, petechiae, bleeding, and itching.…”

Comparing the Healing Effects of Arnebia euchroma Ointment with Petrolatum on the Ulcers Caused by Fractional CO2 Laser: A Single-Blinded Clinical Trial

“…For example, a research compared Aquaphor healing ointment (AHO) (AHO is a formulation of 41% petrolatum, mineral oil, ceresin, lanolin alcohol, panthenol, glycerin, and bisabolol) with Biafine topical emulsion (BTE) (BTE ingredients include purified water, liquid paraffin, ethylene glycol monostearate, stearic acid, propylene glycol, paraffin wax, squalane oil, avocado oil, trolamine/sodium alginate, triethanolamine, cetyl palmitate, methylparaben [sodium salt], sorbic acid [potassium salt], propylparaben [sodiumsalt], and fragrance) on wound healing after fractional CO2 laser resurfacing of the perioral area. Twenty patients applied AHO and BTE to opposite sides of their faces and results showed that AHO can be considered superior to BTE in accelerating healing in wound care after laser resurfacing in comparison with ( 11 ). Another clinical study was conducted to determine the effectiveness of Cicactive (CICA) gel in wound healing after resurfacing laser in comparison with 0.1% silver sulfadiazine cream (CICA gel is a hydrocolloid gel, which is composed of sodium alginate, hydroxyprolisilane, D-panthenol, comfrey great, zinc gluconate and Uriage 30% thermal water.…”

“…CICA gel showed better results in improving wound healing than 0.1% silver sulfadiazine cream did ( 24 ). Silver sulfadiazine is applied as standard topical therapy for patients with partial-thickness burns ( 25 ) and BTE is used in the United States as a topical therapy for a variety of skin traumas including full-thickness wounds, pressure sores, first-degree and second-degree burns, and sunburns ( 11 ). Despite the effect of silver sulfadiazine and BTE on burn wound healing, these studies suggested that CICA gel and AHO could be considered as better topical agents for post-laser wounds.…”

“…Therapeutic effects of current treatments are not satisfactory and petrolatum is still the standard treatment for laser wound care ( 10 ). Treatment should speed up re-epithelialization and reduce rest time, with minimal irritation ( 11 ). Unfortunately, there is no standard care for post-laser resurfacing treatment of the face ( 6 ).…”