A Comparison of Whole Mouth Resting and Stimulated Salivary Measurement Procedures

Navazesh, Mahvash; Christensen, Carol M.

doi:10.1177/00220345820610100901

Cited by 455 publications

(306 citation statements)

References 11 publications

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“…Participants were refrained from eating, drinking, or smoking for at least 2 hours before the test (Navazesh and Christensen, 1982;Navazesh, 1993).…”

Section: Blood and Saliva Samplingmentioning

confidence: 99%

“…Several studies have shown that this marker and others are present in saliva. Thus, its use as a diagnostic fluid could have many advantages comparing to serum: saliva collection is noninvasive, simple, can be collected repeatedly without discomfort of patients and could be a reliable way to detect tumor markers and thus contribute to monitoring the effectiveness of chemotherapy (Navazesh and Christensen, 1982;Streckfus and Bigler, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Significant Correlation between Salivary and Serum Ca 15-3 in Healthy Women and Breast Cancer Patients

Laidi

Bouziane²,

Lakhdar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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The tumor marker CA 15-3 is one of the most import reliable for metastatic breast cancer monitoring. While it is generally assessed in serum of patients, blood sampling is an invasive method compared to saliva sampling which is simple and could be an alternative to blood according to many studies. The aim of this investigation was to assess the relationship between serum and salivary concentrations of the protein CA 15-3 in patients with breast cancer and healthy asymptomatic volunteers. A case-control study was conducted with 60 women: 29 breast cancer patients from the Maternity Hospital Souissi Rabat (Morocco) and 31 healthy asymptomatic women. The CA 15-3 concentrations in saliva and serum samples were assessed using an enzyme immune assay (EIA kits) and comparison between cases and controls was made by the Mann-Whitney test. The correlation between serum and saliva CA 15-3 concentration was tested using Pearson correlation. The comparison result of CA15-3 concentration in saliva and serum level in cases and controls was not statistically significant (p>0.05). However, the correlation between salivary and serum CA 15-3 concentration was positive and statistically significant (r=0.27, p=0.03). In conclusion, the positive correlation between salivary and serum expression found in our study suggests that saliva could be an alternative to blood sampling to help breast cancer monitoring.

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“…Participants were refrained from eating, drinking, or smoking for at least 2 hours before the test (Navazesh and Christensen, 1982;Navazesh, 1993).…”

Section: Blood and Saliva Samplingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Significant Correlation between Salivary and Serum Ca 15-3 in Healthy Women and Breast Cancer Patients

Laidi

Bouziane²,

Lakhdar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Objective measures of saliva quantity and quality are obtained through salivary stimulation 22 and different methods are used to stimulate salivary secretion, including the chewing of gum, paraffin wax, rubber strips, and citric acid. 35 There is evidence that a very low salivary flow significantly increases the risk of developing dental caries 36 , which underscores the importance of the recognition of reduced salivary flow by dentists.…”

Section: Discussionmentioning

confidence: 99%

Association between crack cocaine use and reduced salivary flow

et al. 2017

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Abstract:Crack cocaine use appears to have an impact on oral conditions. However, changes in the salivary flow among crack users have not been fully clarified. The aim of this study was to compare stimulated salivary flow and the occurrence of hyposalivation between crack users and non-users. A cross-sectional study was conducted involving 40 crack users and 40 controls matched for sex, age, and smoking habits. Interviews were conducted to acquire data on the perception of dry mouth (xerostomia) and drug use. Stimulated salivary flow was determined using the spitting method. A significant reduction in stimulated salivary flow was found among crack users in comparison to non-users (1.02 vs. 1.59 ml/min). A total of 42.5% and 15% of crack users had very low and low stimulated salivary flow, respectively. Moreover, 65% of users reported xerostomia in comparison to 37.5% non-users (p < 0.012). No significant association was found between xerostomia and hyposalivation (p = 0.384). A multivariate analysis revealed that individuals older than 26 years of age, those with a low household income, and crack users (prevalence ratio: 2.59) had a significant association with the occurrence of hyposalivation. A significant association was found between the use of crack and reduced salivary flow. The use of crack was associated with the occurrence of hyposalivation in the multivariate analysis.

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“…Unstimulated whole saliva was collected through the spit method, as described by Navazesh and Christensen (19). The unstimulated saliva flow was expressed in mL per 5 min.…”

Section: Oral Examinationsmentioning

confidence: 99%

Association between Root Caries and Depressive Symptoms among Elders in Carlos Barbosa, RS, Brazil

et al. 2017

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The aim of this study was to evaluate the association between depressive symptoms and root caries among independent-living older persons. All community-dwelling older adults (not hospitalized and not bedridden) living in Carlos Barbosa, RS, Brazil, were invited to participate, and 785 completed the study protocol (standardized questionnaire assessing socio-demographic information and health behavior, Geriatric Depression Scale [GDS] -brief version, and oral examination [DMFT-Root index, Visible Plaque Index and stimulated salivary flow]). Out of them, 390 participants with at least one natural tooth were included in the present analysis. The outcome of interest was the ratio between the number of decayed roots and the number of roots at risk. The association between independent variables (depression and socioeconomic aspects) and the outcome was assessed using negative binomial regression models. Results: The final, fully adjusted model revealed that age (β=0.03, p=0.001), female sex (β=-0.23, p=0.08), living in a rural area (β=0.25, p=0.008), tooth brushing frequency (β=0.43, p=0.025) and stimulated salivary flow (β=-0.012, p<0.0001) were significantly associated with the presence of root caries. In addition, the interaction between male sex and the presence of depression symptoms (β=-0.99, p=0.012) was also independently and significantly associated with root caries. The interaction between male sex and depression symptoms was associated with root caries, suggesting that psychological mechanisms may be involved indirectly in the development of root caries in older adults.

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A Comparison of Whole Mouth Resting and Stimulated Salivary Measurement Procedures

Cited by 455 publications

References 11 publications

Significant Correlation between Salivary and Serum Ca 15-3 in Healthy Women and Breast Cancer Patients

Significant Correlation between Salivary and Serum Ca 15-3 in Healthy Women and Breast Cancer Patients

Association between crack cocaine use and reduced salivary flow

Association between Root Caries and Depressive Symptoms among Elders in Carlos Barbosa, RS, Brazil

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