Aim: The purpose of this study was to evaluate the fracture resistance and the mode of failure of endodontically treated teeth with five different post and core systems. A full coverage metal crown was fabricated and cemented onto each tooth. Each specimen was subjected to compressive load at a 130-degree angle to its axis until fracture. The failure load was recorded and compared statistically. The mode of failure of the specimens was analyzed. Results: Cast post and core showed the highest fracture threshold and Titanium post showed the lowest fracture threshold. Cast post and core and titanium post showed evidence of root fracture, which comes under unfavorable fractures. Carbon fiber, Luscent Anchor and Stainless Steel spilt shank post showed either core fracture or a coronal tooth fracture, which comes under favorable fracture, which are restorable. Conclusion: Groups, which have modulus of elasticity close to that of dentin like Carbon fiber post, Luscent Anchor post produced favorable tooth fractures, which are restorable.