A Comparison of Two Objective Measures of Binaural Processing

Haywood, Nicholas R.; Undurraga, Jaime A.; Marquardt, Torsten; McAlpine, David

doi:10.1177/2331216515619039

Cited by 17 publications

(24 citation statements)

References 75 publications

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“…Also the maximum carrier frequency for which IPDs evoke cortical auditory evoked potentials decreases by middle-age ( Papesh et al., 2017 ; Ross et al., 2007 ). Do note that cortical auditory evoked potentials merely indicate a detection of change ( Clinard, Tremblay, & Krishnan, 2010 ), whereas the IPM-FRs extend our knowledge of the auditory system by quantifying the relative processing of different IPM depths ( Haywood et al., 2015 ; McAlpine et al., 2016 ; Undurraga et al., 2016 ).…”

Section: Discussionmentioning

confidence: 99%

“…IPM-FRs presumably originate from neurons in cortical areas ( Haywood et al., 2015 ; McAlpine et al., 2016 ; Undurraga et al., 2016 ). However, changes in IPM-FRs could also reflect reduced low-level temporal resolution.…”

Section: Discussionmentioning

confidence: 99%

“…Neural IPD processing was investigated electrophysiologically by means of interaural phase modulation—following responses (IPM-FRs; Haywood et al., 2015 ; McAlpine et al., 2016 ; Undurraga et al., 2016 ). The IPM-FRs were evoked by IPMs, that is, periodic changes in IPDs over time that were embedded in the TFS of acoustic stimulation.…”

Section: Methodsmentioning

confidence: 99%

“…The IPMs were implemented symmetrically between the two ears, for example, an IPM depth of 180° was implemented as a phase shift of ±90° in each ear (see Figure 2 ). Phase shifts were introduced at the minimum of the modulation cycle to prevent acoustic distortions ( Haywood et al., 2015 ; Undurraga et al., 2016 ).

Figure 2.…”

Section: Methodsmentioning

confidence: 99%

“…To this end, this study examined neural and behavioral IPD processing in six participant groups: young, middle-aged, and older participants, with either normal hearing (NH) thresholds or sensorineural HI (i.e., originating at cochlear or neural level). Neural IPD processing was studied electrophysiologically using a recently developed measure that records neural responses to periodic changes in IPDs over time, embedded in the TFS of acoustic stimuli ( Haywood, Undurraga, Marquardt, & McAlpine, 2015 ; McAlpine, Haywood, Undurraga, & Marquardt, 2016 ; Undurraga, Haywood, Marquardt, & McAlpine, 2016 ). In addition, behavioral IPD processing was examined through IPD discrimination thresholds, obtained for similar stimuli as those applied during the electrophysiological measurements.…”

Section: Introductionmentioning

confidence: 99%

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Electrophysiological and Behavioral Evidence of Reduced Binaural Temporal Processing in the Aging and Hearing Impaired Human Auditory System

et al. 2018

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A person’s ability to process temporal fine structure information is indispensable for speech understanding. As speech understanding typically deteriorates throughout adult life, this study aimed to disentangle age and hearing impairment (HI)-related changes in binaural temporal processing. This was achieved by examining neural and behavioral processing of interaural phase differences (IPDs). Neural IPD processing was studied electrophysiologically through steady-state activity in the electroencephalogram evoked by periodic changes in IPDs over time, embedded in the temporal fine structure of acoustic stimulation. In addition, behavioral IPD discrimination thresholds were determined for the same stimuli. To disentangle potential effects of age from those of HI, both measures were applied to six participant groups: young, middle-aged, and older persons, with either normal hearing or sensorineural HI. All participants passed a cognitive screening, and stimulus audibility was controlled for in participants with HI. The results demonstrated that HI changes neural processing of binaural temporal information for all age-groups included in this study. These outcomes were revealed, superimposed on age-related changes that emerge between young adulthood and middle age. Poorer neural outcomes were also associated with poorer behavioral performance, even though the behavioral IPD discrimination thresholds were affected by age rather than by HI. The neural outcomes of this study are the first to evidence and disentangle the dual load of age and HI on binaural temporal processing. These results could be a valuable first step toward future research on rehabilitation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Figure 2.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electrophysiological and Behavioral Evidence of Reduced Binaural Temporal Processing in the Aging and Hearing Impaired Human Auditory System

et al. 2018

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Neural Representation of Interaural Time Differences in Humans—an Objective Measure that Matches Behavioural Performance

Undurraga

Haywood

Marquardt

et al. 2016

JARO

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Humans, and many other species, exploit small differences in the timing of sounds at the two ears (interaural time difference, ITD) to locate their source and to enhance their detection in background noise. Despite their importance in everyday listening tasks, however, the neural representation of ITDs in human listeners remains poorly understood, and few studies have assessed ITD sensitivity to a similar resolution to that reported perceptually. Here, we report an objective measure of ITD sensitivity in electroencephalography (EEG) signals to abrupt modulations in the interaural phase of amplitude-modulated low-frequency tones. Specifically, we measured following responses to amplitude-modulated sinusoidal signals (520-Hz carrier) in which the stimulus phase at each ear was manipulated to produce discrete interaural phase modulations at minima in the modulation cycle—interaural phase modulation following responses (IPM-FRs). The depth of the interaural phase modulation (IPM) was defined by the sign and the magnitude of the interaural phase difference (IPD) transition which was symmetric around zero. Seven IPM depths were assessed over the range of ±22 ° to ±157 °, corresponding to ITDs largely within the range experienced by human listeners under natural listening conditions (120 to 841 μs). The magnitude of the IPM-FR was maximal for IPM depths in the range of ±67.6 ° to ±112.6 ° and correlated well with performance in a behavioural experiment in which listeners were required to discriminate sounds containing IPMs from those with only static IPDs. The IPM-FR provides a sensitive measure of binaural processing in the human brain and has a potential to assess temporal binaural processing.

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How aging impacts the encoding of binaural cues and the perception of auditory space

2018

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Over the years, the effect of aging on auditory function has been investigated in animal models and humans in an effort to characterize age-related changes in both perception and physiology. Here, we review how aging may impact neural encoding and processing of binaural and spatial cues in human listeners with a focus on recent work by the authors as well as others. Age-related declines in monaural temporal processing, as estimated from measures of gap detection and temporal fine structure discrimination, have been associated with poorer performance on binaural tasks that require precise temporal processing. In lateralization and localization tasks, as well as in the detection of signals in noise, marked age-related changes have been demonstrated in both behavioral and electrophysiological measures and have been attributed to declines in neural synchrony and reduced central inhibition with advancing age. Evidence for such mechanisms, however, are influenced by the task (passive vs. attending) and the stimulus paradigm (e.g., static vs. continuous with dynamic change). That is, cortical auditory evoked potentials (CAEP) measured in response to static interaural time differences (ITDs) are larger in older versus younger listeners, consistent with reduced inhibition, while continuous stimuli with dynamic ITD changes lead to smaller responses in older compared to younger adults, suggestive of poorer neural synchrony. Additionally, the distribution of cortical activity is broader and less asymmetric in older than younger adults, consistent with the hemispheric asymmetry reduction in older adults model of cognitive aging. When older listeners attend to selected target locations in the free field, their CAEP components (N1, P2, P3) are again consistently smaller relative to younger listeners, and the reduced asymmetry in the distribution of cortical activity is maintained. As this research matures, proper neural biomarkers for changes in spatial hearing can provide objective evidence of impairment and targets for remediation. Future research should focus on the development and evaluation of effective approaches for remediating these spatial processing deficits associated with aging and hearing loss.

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A Comparison of Two Objective Measures of Binaural Processing

Cited by 17 publications

References 75 publications

Electrophysiological and Behavioral Evidence of Reduced Binaural Temporal Processing in the Aging and Hearing Impaired Human Auditory System

Electrophysiological and Behavioral Evidence of Reduced Binaural Temporal Processing in the Aging and Hearing Impaired Human Auditory System

Neural Representation of Interaural Time Differences in Humans—an Objective Measure that Matches Behavioural Performance

How aging impacts the encoding of binaural cues and the perception of auditory space

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