2008
DOI: 10.1099/jmm.0.2008/000562-0
|View full text |Cite
|
Sign up to set email alerts
|

A comparison of two methods for the diagnosis of lymphogranuloma venereum

Abstract: A recent outbreak of lymphogranuloma venereum (LGV) within the men who have sex with men (MSM) community and their requirement for extended therapy has highlighted the need for laboratory tests that differentiate LGV-from non-LGV-associated serovars of Chlamydia trachomatis. Two previously described methods were evaluated against 495 clinical specimens referred to the Sexually Transmitted Bacteria Reference Laboratory (London, UK): (i) PCR amplification of a 1.1 kb region of the ompI gene followed by restricti… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
9
0

Year Published

2009
2009
2019
2019

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 12 publications
(9 citation statements)
references
References 11 publications
0
9
0
Order By: Relevance
“…There are multiplex NAATs for genital ulcerative disease that detect LGV but these have not yet been appropriately evaluated in the context of rectal LGV. Different in‐house or laboratory‐developed NAATs have been designed and used . The sensitivities of these NAATs are generally lower than the commercially available C. trachomatis screening NAAT …”
Section: Diagnosismentioning
confidence: 99%
“…There are multiplex NAATs for genital ulcerative disease that detect LGV but these have not yet been appropriately evaluated in the context of rectal LGV. Different in‐house or laboratory‐developed NAATs have been designed and used . The sensitivities of these NAATs are generally lower than the commercially available C. trachomatis screening NAAT …”
Section: Diagnosismentioning
confidence: 99%
“…5 The British Association for Sexual Health & HIV (BASHH) guidelines recommend individuals, especially men who have sex with men (MSM), presenting with symptoms consistent with anorectal syndrome, should be investigated for the presence of LGV infection by detection of LGV-specific DNA, performed on specimens confirmed as chlamydia NAAT positive. 6 Current guidelines recommend a full sexual health screen for all individuals diagnosed with one sexually transmitted infection (STI); for asymptomatic MSM, this includes a first void urine sample, a rectal swab and, subsequent to this project's initiation, a pharyngeal swab to test for chlamydia and gonorrhoea infections. 7,8 Further typing of any positive chlamydia samples from asymptomatic MSM may allow identification of a pool of asymptomatic LGV co-infection in MSM newly diagnosed with HIV, syphilis or hepatitis C leading to earlier detection and potentially a reduction in onward transmission, in addition to identifying other infections through partner notification.…”
Section: Introductionmentioning
confidence: 99%
“…The British Association for Sexual Health & HIV (BASHH) guidelines recommend that individuals, especially men who have sex with men (MSM), presenting with symptoms consistent with anorectal syndrome, should be investigated for the presence of LGV infection by detection of LGV-specific DNA, performed on specimens confirmed as chlamydia nucleic acid amplification test (NAAT) positive. 6…”
Section: Introductionmentioning
confidence: 99%
“…By December 2008, 849 UK cases of LGV had been confirmed 3 . Where full genotyping has been possible, all cases have been confirmed as the L2 serovar of CT 4 . This epidemic has been characterized by a preponderance of proctitis, rather than the classical LGV genital ulcer‐adenopathy syndrome seen in tropical regions and affecting primarily heterosexuals.…”
Section: Introductionmentioning
confidence: 99%
“…By December 2008, 849 UK cases of LGV had been confirmed. 3 Where full genotyping has been possible, all cases have been confirmed as the L2 serovar of CT. 4 This epidemic has been characterized by a preponderance of proctitis, rather than the classical LGV genital ulcer-adenopathy syndrome seen in tropical regions and affecting primarily heterosexuals. In the UK, LGV proctitis has been detected almost exclusively among men who have sex with men (MSM), many of whom are both HIV-positive and report high risk anal sexual practices with multiple and anonymous partners.…”
Section: Introductionmentioning
confidence: 99%