A Comparison of Two Antimicrobial-Impregnated Central Venous Catheters

Darouiche, Rabih O.; Raad, Issam; Heard, Stephen O.; Thornby, John; Wenker, Olivier C.; Gabrielli, A.; Berg, J. van den; Khardori, N.M.; Hanna, Hend; Hachem, Ray; Harris, Richard L.; Mayhall, Glen

doi:10.1056/nejm199901073400101

Cited by 741 publications

(172 citation statements)

References 16 publications

Supporting

Mentioning

155

Contrasting

Unclassified

Order By: Relevance

“…Aseptic techniques for handling the catheters, 27 skin disinfection, 28 impregnating catheters with antibiotics or the use of anticoagulation [29][30][31][32][33] have been proven of value. A study of 356 non-tunneled catheters in cancer patients showed that impregnation of central venous catheters with minocycline and rifampicin was efficacious (3 vs 14 infections in impregnated vs nonimpregnated catheters) and safe in reducing catheter-related infections.…”

Section: Discussionmentioning

confidence: 99%

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

Nieboer

Vries

Mulder

et al. 2008

Bone Marrow Transplant

View full text Add to dashboard Cite

Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. Median catheter dwell time was 25 days (range 1-141). Catheter-related infections were seen in 28.3% of patients (11 infections per 1000 catheter-days). Coagulase-negative staphylococci were found in 104 of 186 positive blood cultures (56%). No systemic fungal infections occurred. Cox regression analysis showed that duration of neutropenia 410 days (P ¼ 0.04), using the catheter for both stem-cell apheresis and high-dose chemotherapy (P ¼ o0.01), and use of total parenteral nutrition (TPN, P ¼ 0.04) were predictive for catheter-related infections. In conclusion, a high incidence of catheter-related infections after high-dose chemotherapy was seen related to duration of neutropenia, use of the catheter for both stem-cell apheresis and high-dose chemotherapy, and use of TPN. Selective use and choice of catheters could lead to a substantial reduction of catheter-related infectious complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

Nieboer

Vries

Mulder

et al. 2008

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…In a multicenter randomized trial, CVCs impregnated on both the external and internal surfaces with minocycline/rifampin were associated with lower rates of CRBSI when compared with the first-generation chlorhexidine-silver sulfadiazine impregnated catheters [91]. The beneficial effect began after day 6 of catheterization.…”

Section: Antimicrobial/antiseptic Impregnated Catheters and Cuffsmentioning

confidence: 99%

Guidelines for the prevention of intravascular catheter-related infections

O’Grady¹,

Alexander²,

Dellinger³

et al. 2002

American Journal of Infection Control

Self Cite

635

843

View full text Add to dashboard Cite

These guidelines have been developed for practitioners who insert catheters and for persons responsible for surveillance and control of infections in hospital, outpatient, and home health-care settings. This report was prepared by a working group comprising members from professional organizations representing the disciplines of critical care medicine, infectious diseases, health-care infection control, surgery, anesthesiology, interventional radiology, pulmonary medicine, pediatric medicine, and nursing. The These guidelines are intended to provide evidencebased recommendations for preventing catheter-related infections. Major areas of emphasis include 1) educating and training health-care providers who insert and maintain catheters; 2) using maximal sterile barrier precautions during central venous catheter insertion; 3) using a 2% chlorhexidine preparation for skin antisepsis; 4) avoiding routine replacement of central venous catheters as a strategy to prevent infection; and 5) using antiseptic/antibiotic impregnated short-term central venous catheters if the rate of infection is high despite adherence to other strategies (i.e., education and training, maximal sterile barrier precautions, and 2% chlorhexidine for skin antisepsis). These guidelines also identify performance indicators that can be used locally by health-care institutions or organizations to monitor their success in implementing these evidence-based recommendations.

show abstract

“…11,12 The antibacterial activity AgNPs The improvement of impregnation of medical devices with silver nanoparticles is that it protects both outer and inner surfaces of medical devices and there is the continuous release of silver ions providing good antimicrobial activity. 13 …”

Section: Introductionmentioning

confidence: 99%

"ANTIBACTERIAL ACTIVITY OF SILVER NANOPARTICLES COATED INTRAVASCULAR CATHETERS (AgNPs-IVC) AGAINST BIOFILM PRODUCING PATHOGENS "

2018

RJC

View full text Add to dashboard Cite

Nanotechnology encompasses the understanding of the fundamental physics, chemistry, biology and technology of nanometre-scale objects. The study of bactericidal nanomaterials is particularly timely considering the recent increase of new resistant strains of bacteria to the most potent antibiotics. In this present study, deals with antibacterial activity of green synthesized silver nanoparticles coated intravascular catheter (AgNPs-IVC) against biofilm producing human pathogens by Zone of inhibition (ZOI) standard microbiology assay. AgNPs-IVC shows excellent antibacterial activity against S. epidermidis and K. pneumoniae, ZOI around 42 mm and 36 mm. The prepared AgNPs-IVC confirms moderate antibacterial activity against S. aureus, E. coli and P. aeruginosa, ZOI around 31, 28 and 27 mm respectively. In addition, SPTT study reveals that the AgNPs-IVC showed a long duration of activities up to Day 8 th against K. pneumoniae and S. epidermidis. Hence, to the utilization of green synthesized silver nanoparticles coated biomedical products to prevent biofilm formation and act as widespread antibacterial materials.

show abstract

A Comparison of Two Antimicrobial-Impregnated Central Venous Catheters

Abstract: The use of central venous catheters impregnated with minocycline and rifampin is associated with a lower rate of infection than the use of catheters impregnated with chlorhexidine and silver sulfadiazine.

Cited by 741 publications

References 16 publications

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

Guidelines for the prevention of intravascular catheter-related infections

"ANTIBACTERIAL ACTIVITY OF SILVER NANOPARTICLES COATED INTRAVASCULAR CATHETERS (AgNPs-IVC) AGAINST BIOFILM PRODUCING PATHOGENS "

Contact Info

Product

Resources

About