A comparison of troponin T and troponin I as predictors of cardiac events in patients undergoing chronic dialysis at a Veteran’s Hospital: a pilot study

Roppolo, Lynn P.; Fitzgerald, Robert L.; Dillow, Jennifer; Ziegler, Thomas W.; Rice, Mitchell F.; Maisel, Alan S.

doi:10.1016/s0735-1097(99)00207-7

Cited by 97 publications

(58 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recentlymyocardial troponin T has increasingly been used as a well-established indicator for diagnosing myocardial infarction (Roppolo et al 1999). Investigations by Senaratne et al (2000) revealed that hyperhomocysteinemia is associated with an increased risk of cardiovascular diseases independently of classical risk factors.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant defence of L-glutamine on mitochondrial function in experimentally induced myocardial infarction in rats

Anandan¹,

Kumar²,

Ganesan³

et al. 2013

Egypt. J. Bio.

View full text Add to dashboard Cite

Myocardial infarction is a major public health concern and the leading cause of death all over the world. A better understanding of the processes involved in myocardial infarction has stimulated the search for biomolecules, which could limit the myocardial injury. We determined the protective activity of L-glutamine on mitochondrial function in isoprenalineinduced myocardial infarction in rats, an animal model of myocardial infarction in man. Oral pre-treatment with glutamine significantly inhibited the isoprenaline-induced changes in the levels of troponin T and homocysteine in the plasma. It conserved the activities of tricarboxylic acid cycle enzymes (isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase) and respiratory marker enzyme (NADH dehydrogenase) and the level of myocardial ATP content at levels comparable to that of normal controls. It also attenuated isoprenaline-induced oxidative stress in rat mitochondria and preserved the antioxidant defence system at near normal. The results indicate that the cardioprotective effect of glutamine can be correlated directly with its ability to activate the energy status and antioxidant defence system.

show abstract

Section: Discussionmentioning

confidence: 99%

Antioxidant defence of L-glutamine on mitochondrial function in experimentally induced myocardial infarction in rats

Anandan¹,

Kumar²,

Ganesan³

et al. 2013

Egypt. J. Bio.

View full text Add to dashboard Cite

show abstract

“…Recent molecular biological studies have elucidated the relation between cytokines evoked by activated macrophages and plaque vulnerability.-Inflammation causes imbalance between fibrous cap degradation and repair. *O Several clinical observations have established a quantitative relationship between the degree and level of inflammation and the clinical outcome in symptomatic and asymptomatic patients with coronary artery disease.l6, 179 21 However, data correlating the markers of inflammation with angiographic anatomy are scarce. Our study confirms previous observations relating inflammation and need for revasc~larization.…”

Section: Discussionmentioning

confidence: 99%

C‐Reactive protein is a marker for a complex culprit lesion anatomy in unstable angina

Moukarbel¹,

Arnaout²,

Alam³

2001

Clinical Cardiology

View full text Add to dashboard Cite

Summary Background:The putative theory is that the clinical syndrome of unstable angina is caused by rupture of the atherosclerotic plaque with superimposed thrombus formation. It is characterized by angiographically complex coronary lesions in the majority of patients.Hypothesis: This study aimed at assessing the correlation between C-reactive protein (CRP) and the complexity of culprit coronary lesions in unstable angina.Methods: We identified culprit lesion complexity in 96 patients with unstable angina and normal creatine kinase (CK)

show abstract

“…For CKD patients who are not receiving dialysis, data are limited and conflicting. [18][19][20] To our knowledge, this is the first study to document the relatively high prevalence of increased cTnT with the degree of renal failure in pre-dialyzed patients. In this study, we demonstrated that there are significant elevations of troponin levels with renal function parameters in CKD patients.…”

Section: Discussionmentioning

confidence: 79%

Increased Cardiac Troponin T Levels Are Related to Inflammatory Markers and Various Indices of Renal Function in Chronic Renal Disease Patients

2012

View full text Add to dashboard Cite

Background/objectives: Cardiovascular disease begins early in the course of chronic kidney disease (CKD), and the glomerular filtration rate (GFR) is an independent risk factor for it. There is little information on cardiac troponin concentrations in patients with CKD who have not commenced dialysis. Factors associated with this deleterious process are not completely understood, and we aimed to determine associated laboratory abnormalities of increased cardiac troponin T (cTnT) in patients with CKD. Methods: In this study, 104 patients (65 males and 39 females with mean age of 65 ± 15 years) were recruited. A detailed clinical history was recorded and routine biochemical variables and cTnT levels were measured. GFR was estimated (44.62 ± 14.38 mL/min/1.73 m 2 ) using the modification of diet in renal disease study formula. Results: cTnT is correlated with blood urea (r = 0.262, p < 0.05), uric acid (r = 0.399, p < 0.001), blood phosphorus (r = 0.550, p < 0.001), triglyceride (r = 0.329, p = 0.011), C-reactive protein (CRP; r = 0.768, p < 0.001), renal resistive index (RRI; r = 0.412, p = 0.017), and GFR (r = −0.755, p = 0.011). On stepwise multiple regression analysis, increased CRP (≥12 mg/L), uric acid (≥5 mg/L), and RRI (≥0.70) were independent variables for increased cTnT status (r 2 = 0.053, p < 0.05). Conclusion: Increased cTnT not only shows ongoing inflammation but also is a sensitive marker of functioning renal mass. It is strongly correlated with factors influencing the decline in renal function; thus, it can be used as a renal risk parameter.

show abstract

A comparison of troponin T and troponin I as predictors of cardiac events in patients undergoing chronic dialysis at a Veteran’s Hospital: a pilot study

Cited by 97 publications

References 25 publications

Antioxidant defence of L-glutamine on mitochondrial function in experimentally induced myocardial infarction in rats

Antioxidant defence of L-glutamine on mitochondrial function in experimentally induced myocardial infarction in rats

C‐Reactive protein is a marker for a complex culprit lesion anatomy in unstable angina

Increased Cardiac Troponin T Levels Are Related to Inflammatory Markers and Various Indices of Renal Function in Chronic Renal Disease Patients

Contact Info

Product

Resources

About