A Comparison of Travoprost, Latanoprost, and the Fixed Combination of Dorzolamide and Timolol in Patients with Pseudoexfoliation Glaucoma

Parmaksiz, Serap; Yüksel, Nurşen; Karabaş, V. Levent; Özkan, Berna; Demirci, Göktuğ; Çağlar, Yusuf

doi:10.1177/112067210601600113

Cited by 48 publications

(48 citation statements)

References 25 publications

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“…Conjunctival hyperaemia is the most common ocular side effect. The incidence and intensity was reported to be higher and more severe than in patients treated with latanoprost (Parmaksiz et al, 2006;Li N et al 2006). Prostaglandin induced iridial pigmentation (PIIP) is another common ocular side effect.…”

Section: Topical Travaprostmentioning

confidence: 99%

Pressure Lowering Medications

Tajudin¹,

Yaakub²

2011

Glaucoma - Current Clinical and Research Aspects

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Section: Topical Travaprostmentioning

confidence: 99%

Pressure Lowering Medications

Tajudin¹,

Yaakub²

2011

Glaucoma - Current Clinical and Research Aspects

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“…A meta-analysis 186 of 14 studies 43,50,60,99,133,[187][188][189][190][191][192][193][194][195] (n = 2149) found latanoprost lowered diurnal mean IOP significantly more than concomitant dorzolamide/timolol (11/14 studies used FCDT) if subjects were uncontrolled on timolol monotherapy (WMD for mean %IOPR was 3.12 (95% CI, 0.47 to 5.78), but was of equal efficacy if no baseline timolol was given. Post-hoc analyses 196 …”

Section: Vs Dual Therapymentioning

confidence: 99%

“…Bimatoprost was superior in IOP lowering to travoprost only during the daytime (0800 and 1200 hours time-points), but latanoprost and travoprost were comparable at all time points (P # 0.82). 88 An industry-sponsored meta-analysis 90 of travoprost vs latanoprost (15 trials, n = 1098), 57,68,85,93,95,96,[98][99][100] travoprost vs bimatoprost (8 trials, n = 714), 57,85,87,93,95,96,101,102 and latanoprost vs bimatoprost (8 trials, n = 943) 57,64,85,86,93,95,96,103 found similar efficacy among the three PGAs. Studies comparing the PGA to other non-PGA glaucoma treatments, nonrandomized, dose-finding or cross-over trials, and short-term evaluations (less than 3 months) were excluded, although a trial evaluating timolol plus travoprost versus timolol alone, 100 was included indicating that the PGA effect has the same relative effect as if it were compared with no treatment.…”

mentioning

confidence: 99%

Clinical utility and differential effects of prostaglandin analogs in the management of raised intraocular pressure and ocular hypertension

Lee

McCluskey

2010

OPTH

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Prostaglandin analogs (PGA) are powerful topical ocular hypotensive agents available for the treatment of elevated intraocular pressure (IOP). Latanoprost 0.005% and travoprost 0.004% are prodrugs and analogs of prostaglandin F2α. Bimatoprost 0.03% is regarded as a prostamide, and debate continues as to whether it is a prodrug. The free acids of all 3 PGAs reduce IOP by enhancing uveoscleral and trabecular outflow via direct effects on ciliary muscle relaxation and remodeling of extracellular matrix. The vast majority of clinical trials demonstrate IOP-lowering superiority of latanoprost, bimatoprost and travoprost compared with timolol 0.5%, brimonidine 0.2%, or dorzolamide 2% monotherapy. Bimatoprost appears to be more efficacious in IOPlowering compared with latanoprost, with weighted mean difference in IOP reduction documented in one meta-analysis of 2.59% to 5.60% from 1-to 6-months study duration. PGAs reduce IOP further when used as adjunctive therapy. Fixed combinations of latanoprost, bimatoprost or travoprost formulated with timolol 0.5% and administered once daily are superior to monotherapy of its constituent parts. PGA have near absence of systemic side effects, although do have other commonly encountered ocular adverse effects. The adverse effects of PGA, and also those found more frequently with bimatoprost use include ocular hyperemia, eyelash growth, and peri-ocular pigmentary changes. Iris pigmentary change is unique to PGA treatment. Once daily administration and near absence of systemic side effects enhances tolerance and compliance. PGAs are often prescribed as first-line treatment for ocular hypertension and open-angle glaucoma.

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“…After looking through a large collection of abstracts of clinical trials on IOP reductions using different drugs, we believe that the above four categories cover a significant proportion of statistical information in abstracts [2,4,9,11,13,14,15,16,18]. In this paper, we concentrate on how to model and merge these four types of information.…”

Section: Statistical Information In Abstractsmentioning

confidence: 99%

“…The following two normal distributions are constructed from [15,16]. In [15] There is another well known method for merging two normal distributions [3] which gives…”

Section: Examplementioning

confidence: 99%

Incomplete Statistical Information Fusion and Its Application to Clinical Trials Data

Liu

Hunter

Lecture Notes in Computer Science

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Abstract. In medical clinical trials, overall trial results are highlighted in the abstracts of papers/reports. These results are summaries of underlying statistical analysis where most of the time normal distributions are assumed in the analysis. It is common for clinicians to focus on the information in the abstracts in order to review or integrate several clinical trial results that address the same or similar medical question(s). Therefore, developing techniques to merge results from clinical trials based on information in the abstracts is useful and important. In reality information in an abstract can either provide sufficient details about a normal distribution or just partial information about a distribution. In this paper, we first propose approaches to constructing normal distributions from both complete and incomplete statistical information in the abstracts. We then provide methods to merge these normal distributions (or sampling distributions). Following this, we investigate the conditions under which two normal distributions can be merged. Finally, we design an algorithm to sequence the merging of trials results to ensure that the most reliable trials are considered first.

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A Comparison of Travoprost, Latanoprost, and the Fixed Combination of Dorzolamide and Timolol in Patients with Pseudoexfoliation Glaucoma

Cited by 48 publications

References 25 publications

Pressure Lowering Medications

Pressure Lowering Medications

Clinical utility and differential effects of prostaglandin analogs in the management of raised intraocular pressure and ocular hypertension

Incomplete Statistical Information Fusion and Its Application to Clinical Trials Data

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