A comparison of tocolysis with nifedipine or ritodrine: Analysis of efficacy and maternal, fetal, and neonatal outcome

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

“…564 The review of inhibition of threatened preterm labour with calcium channel blockers 565 included 12 RCTs. [566][567][568][569][570][571][572][573][574][575][576][577] Updating the searches retrieved a further five RCTs. [578][579][580][581][582] Further details of the review can be found in Appendix 6, Table 133.…”

Comparative study of nifepidine and isoxsuprine in suppression of preterm labour

“…Kalita et al have reported a significantly higher incidence of side effects with isoxsuprine than with nifedipine. 1,4,9,12,17 Tewari et al have reported a much higher incidence of tachycardia in both groups. 11 In the present study, transient hypotension, nausea, vomiting, tachycardia, chest pain, headache in 20%, 10%, 46%, 4%, 30% in nifedipine group.…”

“…It has serious maternal and fetal side effects limiting its use. 4 Beta adrenergic receptor blocking agent isoxsuprine and nifedipine, a calcium channel blocking agent is the most widely used tocolytic agent in India. 5 Several nonrandomized and randomized trials suggest that nifedipine is effective in suppressing preterm labor with minimal side effects on the mother and fetus.…”

Protein Kinase C – Zeta Inhibitors: A New Hope for Controlling Maternal Intrauterine Infection Induced Premature Birth.

“…The studies show that these tocolytic agents only delay premature delivery for at least 48 hours and allow mother to transfer for intensive care unit of neonates. These tocolytic agents do not show any improvement on the side effects of premature birth on infants [49]. The two main pathways that are blocked while preventing premature delivery include the tocolytic agents which blocks myometrial stimulant and alteration of intracellular messengers.…”