A Comparison of Therapeutic and Anti-inflammatory Properties of Triamcinolone and Placebo (Vitamin A) in Treatment of Paederus Dermatitis

Nikookar, Seyed Hassan; Enayati, Ahmad Ali; Haghi, Seyed Farzad Motevalli; Parsi, Behzad; Fazeli‐Dinan, Mahmoud

doi:10.18869/acadpub.jhs.2.3.1

Cited by 2 publications

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References 5 publications

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“…[12] Several countries have reported instances of PD. [1234567891011] Full healing of the lesions takes place within 10–12 days accompanied by transient postinflammatory hyperpigmentation. [121314]…”

Section: Introductionmentioning

confidence: 99%

Evaluation of lymphocyte migration to induced paederus dermatitis: An experimental study in rats

et al. 2019

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Background:Paederus dermatitis (PD) is a blistering disorder that is caused by a small insect of the genus Paederus, especially Paederus fuscipes. This study aimed to investigate the reaction of the adaptive immune system regarding the recruitment of CD3, CCR4, and CCR10 markers, which are specifically expressed on the surface of T lymphocytes.Materials and Methods:In this experimental study, 24 female rats were divided into two groups: the test and the negative control. In the test group, PD was induced by making insects in contact with shaved rat skin. Biopsies were obtained 24, 72, and 120 h after induction. In the negative control group, physiological saline was applied. Specimens were evaluated by immunohistochemical staining method. Antibodies against CD3, CCR4, and CCR10 were used. Distribution and staining intensities of CD3, CCR4, and CCR10 markers were estimated by the H-score index and findings were analyzed using the Kruskal–Wallis and Wilcoxon statistical tests.Results:Based on the results of immunohistochemistry, the expression of CD3, CCR4, and CCR10 in the test group at 24, 72, and 120 h compared to the control group showed significant increase (P = 0.0006, P = 0.001, and P < 0.0001), respectively. The peak of expression of all markers was at 72 h after exposure. Hematoxylin and eosin staining also confirmed the fact that the majority of the lymphocyte infiltration occurred at 72 h postexposure.Conclusion:The expression of CD3, CCR4, and CCR10 on cells present in PD lesions could indicate that T-lymphocytes are recruited to the site of inflammation by chemokine–chemokine receptor interactions and hence provide evidence for the response by the adaptive immune system following a PD.

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Section: Introductionmentioning

confidence: 99%

Evaluation of lymphocyte migration to induced paederus dermatitis: An experimental study in rats

et al. 2019

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Dermatite vésicante à Paederus au Cameroun et revue de littérature

Vanhecke¹,

Gall

Gaüzère

2015

Bull. Soc. Pathol. Exot.

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This irritant blister dermatitis is caused by the genus Paederus whose geographical distribution is worldwide, with a higher incidence in tropical areas. It is induced by direct skin contact with pederin, a blistering and caustic substance found in the abdomen (coelome) of Paederus insects (insect order Coleoptera: family Staphylinidae). The diagnosis is based on the presence of typical clinical features combined with compatible epidemiological features. Our goal is to describe the epidemiological and clinical features of this irritant contact dermatitis in Cameroon through a retrospective study conducted at the end of the rainy season at the Oku Hospital in Northwest Cameroon and to also include cases reported at the medical center of the French Embassy in Yaounde during this same timeframe. In addition, we conducted a literature review of paederus dermatitis. Nineteen patients were included in this study. More than half of the patients presented with more than two lesions predominantly localized to the face or the neck; less than half had complications manifesting as either localized or respiratory reactions and three patients presented periorbital involvement. This study confirms the presence of paederus dermatitis in Cameroon. It is mainly localized in the unusual geoclimatic region of the western high mountains within the country, as well as the usual warm, moist areas of Yaounde. The clinical evolution of this dermatitis is usually one of spontaneous and uneventful resolution with complications being rare. Curative treatment is one of localized topical therapies while oral antibiotic therapy should be reserved for more complicated cases.

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A Comparison of Therapeutic and Anti-inflammatory Properties of Triamcinolone and Placebo (Vitamin A) in Treatment of Paederus Dermatitis

Cited by 2 publications

References 5 publications

Evaluation of lymphocyte migration to induced paederus dermatitis: An experimental study in rats

Evaluation of lymphocyte migration to induced paederus dermatitis: An experimental study in rats

Dermatite vésicante à Paederus au Cameroun et revue de littérature

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