A Comparison of the Vascular Dopamine Receptor with Other Dopamine Receptors

Goldberg, Leon I.; Volkman, Paul H.; Kohli, Jai D.

doi:10.1146/annurev.pa.18.040178.000421

Cited by 316 publications

(92 citation statements)

References 28 publications

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“…It is unlikely that prejunctional inhibition of noradrenaline release plays any role in the cerebrovascular vasodilatation observed in the present study, as there is no evidence that the resting tone of pial arterioles in the present conditions has any sympathetic component (see also the lack pf efficacy of phentolamine in the present study in altering arteriolar calibre) (Kuschinsky & Wahl, 1975). A second population of dopamine receptors is present in vascular smooth muscle in a number of vascular beds (for example, renal, coronary, femoral, mesenteric and splenic arteries), and after blockade of the contractile receptor mechanisms (most commonly with phenoxybenzamine) the actions of dopamine and dopamine receptor agonists cause relaxation of these peripheral arteries (Goldberg & Toda, 1975;Goldberg et al, 1978;Hilditch & Drew, 1981;Toda, 1983). The cerebrovascular dilatation mediated via dopamine receptor activation, noted in the present in situ study and in previous in vitro studies (Toda, 1976;Edvinsson et al, 1978;Oudart et al, 1981;Forster et al, 1983), are comparable, at least in general terms, with these peripheral dopamine receptors mediating vascular smooth muscle relaxation.…”

Section: Administration Of Drugsmentioning

confidence: 69%

“…Vasodilatation via the specific dopamine receptor would appear to be possible only if vessels in regions which are innervated by dopamine-containing nerve fibres, such as the caudate nucleus, did not possess the vasoconstrictor receptors with which dopamine interacts. Dopamine receptors associated with the vasculature are not confined to the cerebral circulation, but have a widespread distribution throughout the body (Goldberg et al, 1978). A population of dopamine receptors in peripheral vessels is localized presynaptically on sympathetic nerve terminals, and the activation of these receptors can modify the release of noradrenaline (Goldberg et al, 1978;Steinsland & Hieble, 1978).…”

Section: Administration Of Drugsmentioning

confidence: 99%

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Vasomotor responses of cerebral arterioles in situ to putative dopamine receptor agonists

Edvinsson

McCulloch

Sharkey

1985

British J Pharmacology

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1 The vasomotor responses of individual cerebral pial arterioles on the convexity of the cerebral cortex to subarachnoid perivascular micro-injections ofdopamine and the putative dopamine receptor agonists, apomorphine, SKF 38393 and LY 141865, have been examined in 38 anaesthetized cats. 2 The perivascular microapplication of dopamine (10-9-10-M) effected dose-dependent reductions in pial arteriolar calibre, with the maximum reductions in calibre (22 ± 2% from preinjection levels: mean ± s.e.) being observed at 10-3M. The cerebrovascular constriction produced by dopamine (10-sM) could be significantly attenuated by the concomitant perivascular administration of phentolamine (10-6M) or methysergide (10-6M). 3 The perivascular microapplication of apomorphine (10-8 10-4M) effected dose-dependent increases in arteriolar calibre, with the maximum increase (31 ± 6%) being observed with apomorphine (10-5M). 4 The perivascular administration of the putative dopamine Di-receptor agonist, SKF 38393 (10-9 1O-4 M) increased arteriolar calibre, with the maximum response (24 ± 3%) being observed with injection of 10-0M. The putative dopamine D2-receptor agonist, LY 141865, also increased cerebral arteriolar calibre, but only at high concentrations (maximum calibre increase 25 ± 6.1 with 10-4 M). 6 These results point to the presence on cat cerebral arterioles ofdopamine receptors (probably of DI subtype) mediating dilatation.

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Section: Administration Of Drugsmentioning

confidence: 69%

Section: Administration Of Drugsmentioning

confidence: 99%

Vasomotor responses of cerebral arterioles in situ to putative dopamine receptor agonists

Edvinsson

McCulloch

Sharkey

1985

British J Pharmacology

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“…10). A DA receptor of the Hg-type may include a pair of anionic and cationic binding sites as suggested by GOLDBERG et al (1978). A 5-HT or 5-MT molecule may bind reasonably strongly to these sites with their NH2 and 5-HO or 5-CH30 groups.…”

Section: ) Effects Of Other Indole Derivatives On the Dahk-type Of Rmentioning

confidence: 99%

Blocking effect of serotonin on inhibitory dopamine receptor activity of Aplysia ganglion cells.

Shozushima

1984

Jpn.J.Physiol

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1) The abdominal ganglion of Aplysia includes neurons with a characteristic dopamine (DA) receptor, the activation of which induces a marked hyperpolarization with a specific increase in the permeability of the membrane to KtThe DA receptor of this type is called the "H K-type." 2) A 2-min exposure to 1,IM serotonin (5-HT) had little effect on the resting membranes with the receptor of HK-type, but significantly depressed the responses to 10 µM DA. The depressing effect of 5-HT on this type of response was completely reversible after a 15-min washing with normal artificial Aplysia blood. 3) Lineweaver-Burke type plotting of the DA-induced responses showed a systematic shift of the straight lines when the concentration of 5-HT was increased; the slope of the line became steeper but the intercept on the ordinate remained unchanged. 4) The dose-inhibition curves, in which relative responses to a given [DA] were plotted against log [5-HT], showed a parallel shift toward the right when the concentration of DA increased. 5) These findings suggest that 5-HT competes with DA for common binding sites at the DA receptor of HK-type, and that the blockade is not due to the interaction of 5-HT with K+-channels in the receptor membrane. 6) The effect of other indole derivatives suggests that the DA receptor of HK-type includes anionic and cationic sites to which the NH2 group and 5-HO group of 5-HT could specifically bind, thus exhibiting competitive blockade.

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“…Peripheral dopamine receptors are subdivided into D1 and D2 subtypes, primarily on the basis of agonist and antagonist profiles of action (Goldberg et al, 1978;1984;Hilditch & Drew, 1985). The D1-dopamine receptors produce smooth muscle relaxation including vasodilatation in the renal, mesenteric, coronary and cerebral vascular beds, and these relaxations are selectively antagonized by SCH 23390.…”

Section: Discussionmentioning

confidence: 99%

Decreased arterial responsiveness to multiple cyclic AMP‐generating receptor agonists in spontaneously hypertensive rats

Masuzawa¹,

Matsuda²,

Asano³

1989

British J Pharmacology

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4 The relaxant responses due to activation of A2-adenosine. H2-histamine and Dj-dopamine receptors were significantly decreased in the SHR arteries. 5 Nitroprusside and nifedipine, agents which are independent of the Gs * AC system, produced similar arterial relaxations in the WKY and SHR. 6 These results support the hypothesis that a reduced function of Gs in the SHR is responsible for the decreased arterial responsiveness to a variety of receptor agonists whose mechanism of action involves AC activation.

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A Comparison of the Vascular Dopamine Receptor with Other Dopamine Receptors

Cited by 316 publications

References 28 publications

Vasomotor responses of cerebral arterioles in situ to putative dopamine receptor agonists

Vasomotor responses of cerebral arterioles in situ to putative dopamine receptor agonists

Blocking effect of serotonin on inhibitory dopamine receptor activity of Aplysia ganglion cells.

Decreased arterial responsiveness to multiple cyclic AMP‐generating receptor agonists in spontaneously hypertensive rats

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