A Comparison of the Tissue Reactions to Plastic Materials

Harrison, John H.

doi:10.1001/archsurg.1957.01280070143018

Cited by 71 publications

(11 citation statements)

References 6 publications

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“…This tissue reaction resulted in gradual formation of an external capsule of granulation tissue, which later filled also the perforations in the wall and the cavity of the chamber. In previous investigations (Harrison et al, 1957;Calnan, 1963;Spangberg, 1968) a very weak tissue reaction to Teflon@ has been reported. Thus, Spangberg (1968) found no inflammatory cells, and only occasionally a sparse zone of connective tissue around 10-week-old Teflon implants in bone tissue.…”

Section: Discussionmentioning

confidence: 85%

“…The model involves the use of subcutaneously implanted wound chambers of polytetrafluorethylene (Teflonm). This material was used since Teflon per se produces no significant tissue reactions (Harrison, Swenson & Lincoln, 1957;Calnan, 1963;Spangberg, 1968). Furthermore, it is possible to section the area subjected to implantation with the chamber in situ.…”

Section: -732912mentioning

confidence: 99%

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Exudation, Inflammatory Cell Migration and Granulation Tissue Formation in Performed Cavities: A Methodological Study

Lundgren

Lindhe

1973

Scandinavian Journal of Plastic and Reconstructive Surgery

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The present paper describes a model for analysis of exudation, cell migration and granulation tissue formation in experimentally induced, aseptic inflammation. The method involves the use of subcutaneously implanted, perforated cylinders of TeflonR. Four cylinders were implanted in each of 100 rats under aseptic conditions and were removed at 12 hours, 4, 7, 14 and 21 days. The amount of exudate accumulated in the chamber cavily was measured and the cell content of the exudate analysed. F:urthermore the morphology of the tissue surrounding the chamber and proliferating into the chamber cavity was described. Particular attention was paid to the vascular system of this tissue using techniques of microangiography and vascular labelling. The course of the inflammatory process throughout the experimental period is discussed in relation to exudation, inflammatory cell migration and granulation tissue formation.

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Section: Discussionmentioning

confidence: 85%

Section: -732912mentioning

confidence: 99%

Exudation, Inflammatory Cell Migration and Granulation Tissue Formation in Performed Cavities: A Methodological Study

Lundgren

Lindhe

1973

Scandinavian Journal of Plastic and Reconstructive Surgery

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“…(4) Tissue-incor¬ porated polyamide mesh is easily carved with a scalpel to fit the indi¬ vidual defect. (5) In the rabbit study, squamous epithelium readily mi¬ grates over purposely exposed incor¬ porated polyamide mesh. This is not likely to occur in other synthetic implants.…”

Section: Discussionmentioning

confidence: 99%

Autoalloplast: An Experimental and Clinical Study

Stucker¹

1982

Archives of Otolaryngology - Head and Neck Surgery

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“…Harrison et al 58 implanted plastics in dogs which were sacrificed at, periods ranging from 1 week to 1 year. Ivalon sponge caused the greatest reaction, followed in order of decreasing reaction by nylon, Dacron, Orlon, and Teflon.…”

Section: Local Effectsmentioning

confidence: 99%

Problems of materials in mechanical heart systems

Akutsu

Kantrowitz

1967

J. Biomed. Mater. Res.

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SummaryCiirrently available materials for mechanical heart systems are surveyed, particularly m-ith respect, to long-term implantation, from the viewpoints of availability and workability, mechanical and biological durability, and compatibilit'y with blood and tissue. Some materials have one or more desirable physical properties, btit none offers perfect blood and tissue compatibility. Medical grade Silastic, considered best, for blood handling parts, has produced promising results in auxiliary ventricle patency exneriments. The insufficient tensile stiength of Silastic should be increased, and it may be possible to accomplish this while maintaining the present resilience, elongation, and inertness. No long-term data on thrombus formation are available, but clot-retarding quality is essential and may perhaps be obtained by incorporating heparin. Developments in polymer chemistry may also lead to other surfaces with the requisite mechanical properties with blood.

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A Comparison of the Tissue Reactions to Plastic Materials

Cited by 71 publications

References 6 publications

Exudation, Inflammatory Cell Migration and Granulation Tissue Formation in Performed Cavities: A Methodological Study

Exudation, Inflammatory Cell Migration and Granulation Tissue Formation in Performed Cavities: A Methodological Study

Autoalloplast: An Experimental and Clinical Study

Problems of materials in mechanical heart systems

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