A comparison of the suppression of cough reflex by intravenous lidocaine and remifentanil prior to extubation of the endotracheal tube

Kang, Dong-Hwa; Kim, Young Whan; Choi, Suk-whan; Lee, Sang-Eun; Lim, Se Hun; Lee, Jeong-Han; Lee, Kun Moo; Cheong, Soon Ho; Choe, Young Kyun; Kim, Young Jae; Shin, Chee Mahn

doi:10.4097/kjae.2008.55.4.452

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Various efforts have been made to reduce coughing during the time the patient awakens; such efforts include the administration of lidocaine either intravenously or topically, sub-hypnotic propofol, and remifentanil [ 12 – 14 ]. Dexmedetomidine has sedative and analgesic effects without significant respiratory depression and can be used during stressful procedures such as awake intubation [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine decreased the post‐thyroidectomy bleeding by reducing cough and emergence agitation – a randomized, double‐blind, controlled study

Kim

et al. 2021

BMC Anesthesiol

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Background Bleeding after thyroidectomy occurs due to violent coughing during emergence. Dexmedetomidine is helpful for the smooth emergence and suppression of cough. The purpose of the present study was to compare the effects of dexmedetomidine on postoperative bleeding after thyroidectomy. Methods Randomized, double-blind, controlled trials were conducted in female patients (ASA I–II, aged 20 to 60 years). The patients were randomly allocated into two groups. Approximately 15 min before the end of the surgery, dexmedetomidine was administered (0.6 µg/kg/h) without a loading dose in group D (n = 69), and normal saline was administered in group S (n = 70) at the same infusion rate. Hemodynamic data, coughing reflex, extubation time, Ramsay sedation scale (RSS), and recovery time were assessed during the administration of the study drugs and recovery from anesthesia. The amount of postoperative hemorrhage was measured for 3 days. Results Data from a total of 139 patients were analyzed. The incidence of severe cough was significantly lower in group D than in group S (4.3 % vs. 11.5 %, P = 0.022). The emergence agitation in the postanesthetic care unit was significantly lower in group D than in group S (P = 0.01). Postoperative bleeding was significantly lower in group D than in group S until the second postoperative day (P = 0.015). Conclusions Dexmedetomidine can be helpful in decreasing bleeding after thyroidectomy by reducing coughing and emergence agitation. Trial registration This study was registered at http://clinicaltrials.gov (registration number NCT02412150, 09/04/2015).

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Section: Discussionmentioning

confidence: 99%

Dexmedetomidine decreased the post‐thyroidectomy bleeding by reducing cough and emergence agitation – a randomized, double‐blind, controlled study

Kim

et al. 2021

BMC Anesthesiol

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show abstract

“…There were various efforts to reduce coughing during the awake period, such as intravenous or topical lidocaine, sub-hypnotic propofol, and remifentanil [11][12][13]. Dexmedetomidine has sedative and analgesic effects without signi cant respiratory depression which can be used during the stressful procedure such as awake intubation [14].…”

Section: Discussionmentioning

confidence: 99%

A small dose of dexmedetomidine decreased the postoperative bleeding by reducing cough and emergence agitation after thyroidectomy – A randomized, double-blind, controlled study

Kim

et al. 2021

Preprint

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Background: Bleeding after a thyroidectomy occurs due to violent cough during the emergence. Dexmedetomidine is helpful for smooth emergence and suppressing the cough. The purpose of the present study was to compare the effect of dexmedetomidine on postoperative bleeding after thyroidectomy. Methods: Randomized, double-blind, controlled trial in female patients (ASA I–II, aged 20 to 60 years) were conducted. Patients were randomly allocated into two groups. About fifteen minutes before the end of the surgery, dexmedetomidine was administered (0.6 μg/kg/hr) without a loading dose in group D (n=69), and normal saline was administered in group S (n=70) at the same infusion rate. Hemodynamic data, coughing reflex, extubation time, Ramsay sedation scale (RSS), recovery time were assessed during the administration of study drugs and recovery from anesthesia. Amounts of postoperative hemorrhage were measured for 3 days. Results: A total of 139 patients were analyzed. The incidence of severe cough was significantly decreased in group D compared to group S (4.3% vs. 11.5%, P = 0.022). Emergence agitation in the postanesthetic care unit was significantly decreased in group D compared to group S (P = 0.01). Postoperative bleeding showed a significant decrease in group D compared to group S until the second postoperative day (P = 0.015). Conclusions: Dexmedetomidine can decrease postoperative bleeding by reducing coughing and emergence agitation after thyroidectomy. Trial registration: This study was registered at http://clinicaltrials.gov (registration number NCT02412150, 09/04/2015).

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A comparison of the suppression of cough reflex by intravenous lidocaine and remifentanil prior to extubation of the endotracheal tube

Cited by 2 publications

References 29 publications

Dexmedetomidine decreased the post‐thyroidectomy bleeding by reducing cough and emergence agitation – a randomized, double‐blind, controlled study

Dexmedetomidine decreased the post‐thyroidectomy bleeding by reducing cough and emergence agitation – a randomized, double‐blind, controlled study

A small dose of dexmedetomidine decreased the postoperative bleeding by reducing cough and emergence agitation after thyroidectomy – A randomized, double-blind, controlled study

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