A comparison of the Ranson, Glasgow, and APACHE II scoring systems to a multiple organ system score in predicting patient outcome in pancreatitis

Taylor, Stephanie L.; Morgan, Daniel L.; Denson, Kent D.; Lane, Mary M.; Pennington, Larry R.

doi:10.1016/j.amjsurg.2004.11.010

Cited by 53 publications

(32 citation statements)

References 6 publications

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“…Previous findings have shown that the severity of encephalopathy was associated with the global severity of disease, as assessed by APACHE II score or SOFA, and mortality rates (1,2). In the present study, the mortality of septic patients significantly increased with increased APACHE II and SOFA scores, which is consistent with previous reports (30), supporting an association of SE with an increased mortality risk in patients with severe sepsis.…”

Section: Discussionsupporting

confidence: 92%

Peripheral T-lymphocyte and natural killer cell population imbalance is associated with septic encephalopathy in patients with severe sepsis

Qiu

Tong

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Septic encephalopathy (SE) is a diffuse cerebral dysfunction resulting from a systemic inflammatory response, and is associated with an increased risk of mortality. The pathogenesis of SE is complex and multifactorial, but unregulated immune imbalance may be an important factor. The current retrospective study examined the clinical data of 86 patients with severe sepsis who were admitted to the Intensive Care Unit at Zhongshan Hospital, Xiamen University (Xiamen, China) from January, 2014 to January, 2015. The patients were assigned to SE and non-SE patient groups according to the presence or absence of SE. The proportion of T-lymphocyte subsets and natural killer (NK) cells in the immune cell population, representing the function of the immune system, were analyzed for their association with SE and compared with other clinical predictors and biomarkers. + T-lymphocytes were demonstrated to be independently associated with SE (respectively, P=0. 012 and OR, 4.763; P=0.005 and OR, 0.810). An area under the curve analysis of a receiver operating characteristic curve of the two indicators revealed that these were equally powerful measures in prediction of SE (Z=1.247, P>0.05). The present results confirm that SE leads to higher mortality in patients with severe sepsis, and demonstrate that immune imbalance is important in the development of SE. The proportion of CD4 + T-lymphocytes present were revealed in the current study to be a powerful predictor of SE in patients with severe sepsis.

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Section: Discussionsupporting

confidence: 92%

Peripheral T-lymphocyte and natural killer cell population imbalance is associated with septic encephalopathy in patients with severe sepsis

Qiu

Tong

et al. 2016

Experimental and Therapeutic Medicine

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“…Also, AST level was significantly higher in severe AP than in mild AP. AST, which is a component of various scoring systems, is a marker of serious liver damage [6,10] . Higher levels of bilirubin in biliary AP in comparison with other forms are not surprising.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, age had no association with disease severity, morbidity or mortality. A multiorgan system score has been developed to supersede the APACHE Ⅱ and Ranson scores, but the number of cases in that report is small [10] .…”

Section: Discussionmentioning

confidence: 99%

“…The APACHE Ⅱ score and the CRP level have been reported to be useful markers. Although there is a general consensus on the value of CRP, conflicting opinions have been expressed on the APACHE Ⅱ score [10] . In this study from a tertiary referral center, we aimed to present the characteristics of the AP cases and to identify clinical, radiological and laboratory parameters as RESULTS: One hundred patients were men and 99 were women; the mean age was 55 years.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of diagnostic findings and scoring systems in outcome prediction in acute pancreatitis

Kaya¹,

Dervişoğlu²,

Polat³

2007

WJG

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AIM:To determine factors related to disease severity, mortality and morbidity in acute pancreatitis. METHODS:One hundred and ninety-nine consecutive patients were admitted with the diagnosis of acute pancreatitis (AP) in a 5-year period (1998)(1999)(2000)(2001)(2002). In a prospective design, demographic data, etiology, mean hospital admission time, clinical, radiological, biochemical findings, treatment modalities, mortality and morbidity were recorded. Endocrine insufficiency was investigated with oral glucose tolerance test. The relations between these parameters, scoring systems (Ranson, Imrie and APACHE Ⅱ) and patients' outcome were determined by using invariable tests and the receiver operating characteristics curve.

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“…In spite of their abundance, there is still a lack of single scale that can quickly, precisely and unequivocally set proper diagnosis in different life-threatening conditions. Moreover, many from the recently devised scales are based on parameters that require significant time or sophisticated techniques to obtain results (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). A system established to assess patient clinical status and aid in making proper diagnosis -especially in situations requiring immediate interventions -could improve the process of initial triage in Emergency Departments with limited access to highly specialized diagnostic techniques.…”

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confidence: 99%

Models of Certain Types of Surgical Shock Based on the Assessment of Selected Critical Parameters

Budzyński

Brongel

Nazimek

et al. 2007

Polish Journal of Surgery

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The aim of the study was to devise models that describe three types of surgical shock based on a set of simple biochemical and clinical parameters and establish a method of assigning new patients to each surgical shock scenario. Material and methods. Prospective analysis included patients hospitalized in IInd Chair of Surgery from 2001 to 2005 who belonging to the following groups: multiple injuries (at least 7 points according to LSO), upper GI bleeding (in patients requiring blood transfusions during first day) and severe acute pancreatitis (at least 3 rd degree according to Trapnell's scale). A set of nineteen parameters was evaluated on the first, fourth and seventh day in every patient. Discrimination analysis was used for statistical analysis with calculation of Mahalanobis squared distances between groups that reflect their reciprocal differences. Discrimination functions were calculated allowing the assignment of a new observation to one of the models. Eventually, reliability of categorizing patients to the studied groups was evaluated. Results. Differences among the groups -reflected by Mahalanobis squared distances -proved statistically significant in every studied day. Overall, the ratio of proper classifications according to discrimination functions equaled about 87%. The most common mistake in categorizing was observed in groups of multiple injuries and acute pancreatitis -due to similar pathophysiological processes leading through SIRS to MOF. Conclusions. The abovementioned results indicate that the presented models can be successfully used in diagnostic processes, especially in emergency cases. The set of clinical and biochemical parameters used is simple and easy to obtain even in non-specialized centers. Key words: multiple injuries, acute pancreatitis, upper GI bleeding, discrimination analysis POLSKI PRZEGLĄD CHIRURGICZNY 10.2478/v10035-007-0054-2 2007 Significant effort was made to create a uniform system for the assessment of patient clinical status -regardless of the underlying disease, which would serve as a help for making therapeutic decisions and evaluating prognosis. For this purpose, many scales assessing the severity of homeostatic disturbances were created. In spite of their abundance, there is still a lack of single scale that can quickly, precisely and unequivocally set proper diagnosis in different life-threatening conditions. Moreover, many from the recently devised scales are based on parameters that require significant time or sophisticated techniques to obtain results (1-11). A system established to assess patient clinical status and aid in making proper diagnosis -especially in situations requiring immediate interventions -could improve the process of initial triage in Emergency Departments with limited access to highly specialized diagnostic techniques.The aim of this study was to create models of response in three commonly found settings of surgical and traumatological shock based on a set of selected critical parameters.

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A comparison of the Ranson, Glasgow, and APACHE II scoring systems to a multiple organ system score in predicting patient outcome in pancreatitis

Cited by 53 publications

References 6 publications

Peripheral T-lymphocyte and natural killer cell population imbalance is associated with septic encephalopathy in patients with severe sepsis

Peripheral T-lymphocyte and natural killer cell population imbalance is associated with septic encephalopathy in patients with severe sepsis

Evaluation of diagnostic findings and scoring systems in outcome prediction in acute pancreatitis

Models of Certain Types of Surgical Shock Based on the Assessment of Selected Critical Parameters

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