A comparison of the radiosensitisation ability of 22 different element metal oxide nanoparticles using clinical megavoltage X-rays

Guerreiro, Alexandra; Chatterton, Nicholas P.; Crabb, Eleanor M.; Golding, Jon P.

doi:10.1186/s12645-019-0057-9

Cited by 21 publications

(23 citation statements)

References 64 publications

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“…The lack of systematic evaluation of metal oxide NPs in parallel, led Guerreiro et al to assess ROS production effect of 22 NP suspensions following 10 Gy of 6‐MV X‐ray photon irradiation. 49 Key highlights from their ROS production assessment demonstrated that: V 2 O 5 produced the most hydroxyls upon radiation (further increased in comparison to its production of hydroxyls at baseline, i.e., without radiation, which was already significantly greater than other NPs), while lanthanides did not produce any (both at baseline and with radiation), TiO 2 showed a trend toward increased superoxide anion production with radiation, MoO 3 demonstrated a protective effect as highlighted by the decreased superoxide anion level detected compared to water, and the following NPs induced a protective effect regarding singlet oxygen production: V 2 O 5 , NiO, CuO, MoO 3 , (Z between 23 and 42), Nd 2 O 3 , Eu 2 O 3 , Gd 2 O 3 , Dy 2 O 3 (Z between 60 and 66). 49 As previously explained, this suggests that surface chemistry of NPs may be the key parameter instead of atomic number.…”

Section: Preclinical Studies Based On the Use Of Nano‐sensitizers In Cancer Radiation Therapymentioning

confidence: 99%

Radiation nanosensitizers in cancer therapy—From preclinical discoveries to the outcomes of early clinical trials

Bilynsky

Millot

Papa

2021

Bioengineering & Transla Med

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Improving the efficacy and spatial targeting of radiation therapy while sparing surrounding normal tissues has been a guiding principle for its use in cancer therapy. Nanotechnologies have shown considerable growth in terms of innovation and the development of new therapeutic approaches, particularly as radiosensitizers. The aim of this study was to systematically review how nanoparticles (NPs) are used to enhance the radiotherapeutic effect, including preclinical and clinical studies. Clinicaltrials.gov was used to perform the search using the following terms: radiation, cancer, and NPs. In this review, we describe the various designs of nano‐radioenhancers, the rationale for using such technology, as well as their chemical and biological effects. Human trials are then discussed with an emphasis on their design and detailed clinical outcomes.

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Section: Preclinical Studies Based On the Use Of Nano‐sensitizers In Cancer Radiation Therapymentioning

confidence: 99%

Radiation nanosensitizers in cancer therapy—From preclinical discoveries to the outcomes of early clinical trials

Bilynsky

Millot

Papa

2021

Bioengineering & Transla Med

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“…A [55]. The role of nanostructures in the detection of various gases, or ionizing radiation, is expected to be developed especially in p-n structures, CMOS, various strip detectors, AC coupled strip detectors, double strip detectors, pixel detectors, hybrid pixel detectors, various drift detectors, different SSD, and other bi/three nanodimensional structures.…”

Section: New Perspectivesmentioning

confidence: 99%

Additive Manufacturing as a Means of Gas Sensor Development for Battery Health Monitoring

et al. 2021

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Lithium-ion batteries (LIBs) still need continuous safety monitoring based on their intrinsic properties, as well as due to the increase in their sizes and device requirements. The main causes of fires and explosions in LIBs are heat leakage and the presence of highly inflammable components. Therefore, it is necessary to improve the safety of the batteries by preventing the generation of these gases and/or their early detection with sensors. The improvement of such safety sensors requires new approaches in their manufacturing. There is a growing role for research of nanostructured sensor’s durability in the field of ionizing radiation that also can induce structural changes in the LIB’s component materials, thus contributing to the elucidation of fundamental physicochemical processes; catalytic reactions or inhibitions of the chemical reactions on which the work of the sensors is based. A current method widely used in various fields, Direct Ink Writing (DIW), has been used to manufacture heterostructures of Al2O3/CuO and CuO:Fe2O3, followed by an additional ALD and thermal annealing step. The detection properties of these 3D-DIW printed heterostructures showed responses to 1,3-dioxolan (DOL), 1,2-dimethoxyethane (DME) vapors, as well as to typically used LIB electrolytes containing LiTFSI and LiNO3 salts in a mixture of DOL:DME, as well also to LiPF6 salts in a mixture of ethylene carbonate (EC) and dimethyl carbonate (DMC) at operating temperatures of 200 °C–350 °C with relatively high responses. The combination of the possibility to detect electrolyte vapors used in LIBs and size control by the 3D-DIW printing method makes these heterostructures extremely attractive in controlling the safety of batteries.

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“…Upon irradiation, metal nanoparticles, with their high surface area and surface chemistries, have shown intrinsic radiocatalytic activities in water producing reactive oxygen species (ROS), thus, effectively increasing the overall radical concentration. [13] Furthermore, interactions of X-ray with metals with high atomic number (high Z) are known to enhance the photoelectric and Compton effects that result in radiation dose-enhancements. [11] Most studies have focused on gold (Z=79) nanoparticles and signi cant evidences have been reported to demonstrate their ability to increase the therapeutic ratio of radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Excretable, ultrasmall hexagonal NaGdF4:Yb50% Nanoparticles for bimodal imaging and radiosensitization

Damasco

Ohulchanskyy

Mahajan

et al. 2021

Preprint

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Background: In this study, we report on the synthesis, imaging and radiosensitizing properties of ultrasmall β-NaGdF4:Yb50% nanoparticles as a multifunctional theranostic platform. The synthesized nanoparticles act as potent bimodal contrast agents with superior imaging properties compared to existing agents used for magnetic resonance imaging (MRI) and computed tomography (CT). Clonogenic assays demonstrated that these nanoparticles can act as effective radiosensitizers, provided the nanoparticles are taken up intracellularly.Results: Our ultrasmall β-NaGdF4:Yb50% nanoparticles demonstrate improvement in T1-weighted contrast over the standard clinical MR imaging agent Gd-DTPA and similar CT signal enhancement capabilities as commercial agent iohexol. A 2 Gy dose of X-ray induced ~20% decrease in colony survival when C6 rat glial cells were incubated with non-targeted nanoparticles (NaGdF4:Yb50%), whereas the same X-ray dose resulted in a ~60% decrease in colony survival with targeted nanoparticles conjugated to folic acid (NaGdF4:Yb50%-FA). Intravenous administration of nanoparticles resulted in clearance through urine and feces within a short duration, based on the ex vivo analysis of Gd3+ ions via ICP-MS.Conclusion: These biocompatible and in vivo clearable ultra-small NaGdF4:Yb50% are promising candidates for further evaluation in image-guided radiotherapy applications.

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A comparison of the radiosensitisation ability of 22 different element metal oxide nanoparticles using clinical megavoltage X-rays

Cited by 21 publications

References 64 publications

Radiation nanosensitizers in cancer therapy—From preclinical discoveries to the outcomes of early clinical trials

Radiation nanosensitizers in cancer therapy—From preclinical discoveries to the outcomes of early clinical trials

Additive Manufacturing as a Means of Gas Sensor Development for Battery Health Monitoring

Excretable, ultrasmall hexagonal NaGdF4:Yb50% Nanoparticles for bimodal imaging and radiosensitization

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