A Comparison of the Placental Transfer of Ropivacaine Versus Bupivacaine

Johnson, Raymond F.; Cahana, Alex; Olenick, M.; Herman, N.; Paschall, Ray L.; Minzter, Beth H.; Ramasubramanian, R.; Gonzalez, Herbert; Downing, J. W.

doi:10.1097/00000539-199909000-00032

Cited by 13 publications

(6 citation statements)

References 15 publications

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“…At the end of 2 h perfusion, clearance (Cl m→f ) of ropivacaine and antipyrine was 0.56 ± 0.16 and 0.75 ± 0.20 mL/min, respectively. The clearance index (CI) of ropivacaine was 0.75 ± 0.17 (n = 6), which agrees with previously reported data (Johnson et al, 1999). No…”

Section: Transplacental Studysupporting

confidence: 92%

“…These freshly obtained placentas were perfused immediately via the umbilical artery using cold (4°C) heparinized 0.9% NaCl solution. Transplacental study of ropivacaine was performed on an open (single pass mode) perfusion system, as described in the literature (Johnson et al, 1999). The perfusion was performed with 250 mL drug-free plasma in maternal side and 100 mL KRB solution with 4 g/100mL albumin in the fetal circuit.…”

Section: Methods Validationmentioning

confidence: 99%

“…Antipyrine was selected as an ideal marker of placental transfer as it is of moderate solubility and does not bind to plasma proteins. Antipyrine has been determined either spectrophotometrically or by high performance liquid chromatography in some reported transplacental studies (Heikkine et al, 2002;Johnson et al, 1999). The simultaneous analysis of ropivacaine and antipyrine has not been reported.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous determination of ropivacaine and antipyrine by high performance liquid chromatography and its application to the in vitro transplacental study

Zuo

Duan

2004

Biomedical Chromatography

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A simple and reliable RP-HPLC method has been developed for the simultaneous determination of ropivacaine and antipyrine in perfusate samples. Samples were analyzed on an ODS column with UV detection at 210 nm after liquid-liquid extraction. The mobile phase consisted of potassium dihydrogenphosphate (25 mM, adjusted to pH 5.0 with phosphoric acid)-acetonitrile (79:21, v/v). The method has been validated to be precise, accurate and linear. It has been applied to the investigation of placental transfer of ropivacaine via a dually perfused cotyledon model of human placenta in vitro.

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Section: Transplacental Studysupporting

confidence: 92%

Section: Methods Validationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Simultaneous determination of ropivacaine and antipyrine by high performance liquid chromatography and its application to the in vitro transplacental study

Zuo

Duan

2004

Biomedical Chromatography

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“…However, it has a lower threshold for cardiovascular and CNS toxicity than lidocaine in rats, pigs and humans (Feldman et al. 1989; Johnson et al. 1999).…”

Section: Discussionmentioning

confidence: 99%

Brachial plexus blockade in chickens with 0.75% ropivacaine

Cardozo

Almeida

Fiúza

et al. 2009

Veterinary Anaesthesia and Analgesia

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“…and clinical studies have failed to show that ropivacaine or levobupivacaine offers any advantage over bupivacine in terms of placental transfer and/or neonatal outcome. [108][109][110]…”

Section: Dovepressmentioning

confidence: 99%

Progress in analgesia for labor: focus on neuraxial blocks

Ranasinghe

Birnbach

2009

IJWH

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Neuraxial analgesia is widely accepted as the most effective and the least depressant method of providing pain relief in labor. Over the last several decades neuraxial labor analgesia techniques and medications have progressed to the point now where they provide high quality pain relief with minimal side effects to both the mother and the fetus while maximizing the maternal autonomy possible for the parturient receiving neuraxial analgesia. The introduction of the combined spinal epidural technique for labor has allowed for the rapid onset of analgesia with minimal motor blockade, therefore allowing the comfortable parturient to ambulate. Patient-controlled epidural analgesia techniques have evolved to allow for more flexible analgesia that is tailored to the individual needs of the parturient and effective throughout the different phases of labor. Computer integrated systems have been studied to provide seamless analgesia from induction of neuraxial block to delivery. New adjuvant drugs that improve the effectiveness of neuraxial labor analgesia while decreasing the side effects that may occur due to high dose of a single drug are likely to be added to future labor analgesia practice. Bupivacaine still remains a popular choice of local anesthetic for labor analgesia. New local anesthetics with less cardiotoxicity have been introduced, but their cost effectiveness in the current labor analgesia practice has been questioned.

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A Comparison of the Placental Transfer of Ropivacaine Versus Bupivacaine

Cited by 13 publications

References 15 publications

Simultaneous determination of ropivacaine and antipyrine by high performance liquid chromatography and its application to the in vitro transplacental study

Simultaneous determination of ropivacaine and antipyrine by high performance liquid chromatography and its application to the in vitro transplacental study

Brachial plexus blockade in chickens with 0.75% ropivacaine

Progress in analgesia for labor: focus on neuraxial blocks

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