A comparison of the outcomes between surgical resection and proton beam therapy for single primary hepatocellular carcinoma

Tamura, Shunsuke; Okamura, Yukiyasu; Sugiura, Teiichi; Ito, Takaaki; Yamamoto, Yusuke; Ashida, Ryo; Ohgi, Katsuhisa; Murayama, Shigeyuki; Uesaka, Katsuhiko

doi:10.1007/s00595-019-01888-5

Cited by 13 publications

(10 citation statements)

References 23 publications

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“…Because of this feature, PBT can provide higher doses to LRRC, while minimizing unnecessary irradiation of the surrounding, radiosensitive organs. In recent decades, the efficacy and feasibility of PBT has been reported for diverse cancers such as the liver, esophagus, or pancreas (9)(10)(11)(12)(13)(14)(15).…”

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confidence: 99%

Proton Beam Therapy for Local Recurrence of Rectal Cancer

et al. 2021

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Background/Aim: Curing local recurrence of rectal cancer (LRRC) is difficult with conventional photon radiotherapy. Proton beam therapy (PBT) on the other hand, has unique physical characteristics that permit higher doses to LRRC while minimizing side effects on surrounding organs. However, the efficacy of PBT on controlling rectal cancer recurrence has not yet been reported. This study aimed to evaluate clinical outcomes and toxicities of PBT for LRRC. Patients and Methods: Clinical outcomes were retrospectively evaluated for 12 patients with 13 total lesions that had received PBT for LRRC at our institute. Results: The median follow-up period from the initiation of PBT was 35.6 months. The 3-year local control, progression-free survival and overall survival rates were 80.2%, 10.4% and 73.8%, respectively. Median survival time was 67.1 months. There were no severe acute or late adverse events. Conclusion: PBT could be a safe and effective treatment method for LRRC.

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confidence: 99%

Proton Beam Therapy for Local Recurrence of Rectal Cancer

et al. 2021

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“…Moving on to operable tumors, Tamura et al compared PBT and surgical resection [ 79 ]. Patients with single nodular HCC tumors of maximal diameter 10 cm and no vascular invasion were selected (n = 31 PBT vs. n = 314 surgical resection).…”

Section: Clinical Datamentioning

confidence: 99%

Proton Therapy in the Management of Hepatocellular Carcinoma

Kobeissi

Hilal

Simone

et al. 2022

Cancers

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Proton radiation therapy plays a central role in the treatment of hepatocellular carcinoma (HCC). Because of the near-zero exit dose and improved sparing of normal liver parenchyma, protons are being used even in challenging scenarios, including larger or multifocal liver tumors, and those associated with vascular tumor thrombus. There is a mounting level of evidence that suggests that protons are superior to photons in terms of survival and toxicity outcomes, specifically the progression to liver failure. A randomized controlled trial comparing protons to photons is currently underway to verify this hypothesis.

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“…Tamura et al. recently reported the results of a retrospective comparison between surgery and PT for single HCC ≤100 mm without vessel invasion ( 25 ). The authors found that the median survival time in the surgery group was significantly better than in the PT group.…”

Section: Proton Vs Other Treatment Optionsmentioning

confidence: 99%

Proton therapy in the treatment of hepatocellular carcinoma

et al. 2022

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Liver cancer represents one of the most common causes of death from cancer worldwide. Hepatocellular carcinoma (HCC) accounts for 90% of all primary liver cancers. Among local therapies, evidence regarding the use of radiation therapy is growing. Proton therapy currently represents the most advanced radiation therapy technique with unique physical properties which fit well with liver irradiation. Here, in this review, we aim to 1) illustrate the rationale for the use of proton therapy (PT) in the treatment of HCC, 2) discuss the technical challenges of advanced PT in this disease, 3) review the major clinical studies regarding the use of PT for HCC, and 4) analyze the potential developments and future directions of PT in this setting.

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A comparison of the outcomes between surgical resection and proton beam therapy for single primary hepatocellular carcinoma

Cited by 13 publications

References 23 publications

Proton Beam Therapy for Local Recurrence of Rectal Cancer

Proton Beam Therapy for Local Recurrence of Rectal Cancer

Proton Therapy in the Management of Hepatocellular Carcinoma

Proton therapy in the treatment of hepatocellular carcinoma

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