A Comparison of the New Preservation Solution Celsior to Euro-Collins and University of Wisconsin Solutions in Lung Reperfusion Injury1

Roberts, Randall F.; Nishanian, Garabed P.; Carey, Joseph N.; Sakamaki, Yasushi; Starnes, Vaughn A.; Barr, Mark L.

doi:10.1097/00007890-199901150-00025

Cited by 51 publications

(25 citation statements)

References 14 publications

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“…8 A new preserving solution, Celsior solution (CS) (SangStat Medical Corporation, Fremont, CA), 9 recently has become available that might theoretically offer a new means for improving graft preservation quality and probably also graft outcome. CS is an extracellular type of solution initially used successfully in heart transplantation 9 and more recently shown to be an effective alternative to UW solution in preserving such thoracic and abdominal organs as the lung, 10 kidney, 11 small intestine, 12 and pancreas. 13 Given its low viscosity and antioxidant and antiedema properties, 9 CS might be particularly suitable for preserving livers; however, data from the clinical setting of OLT have been scanty to date.…”

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confidence: 99%

A multicenter pilot prospective study comparing Celsior and University of Wisconsin preserving solutions for use in liver transplantation

Cavallari

Cillo

Nardo

et al. 2003

Liver Transplantation

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Primary dysfunction (PDF) still occurs after orthotopic liver transplantation (OLT). Celsior solution (CS) might offer some advantages over the conventional University of Wisconsin (UW) solution for organ preservation, but to date, this has not been prospectively evaluated in the context of OLT. In this prospective, randomized, multicenter, pilot study, 215 potential liver donors were enrolled and randomized. In 42 cases, the livers were unsuitable for transplantation; therefore, 173 randomized livers ultimately were implanted after perfusion and cold preservation with CS (n ‫؍‬ 83) or UW solution (n ‫؍‬ 90). In accord with the indications of the CS manufacturing company, total CS infusion volume was 90 mL/kg, greater than that of UW solution (60 mL/kg). The main aim of the study is to compare the prevalence of PDF between the two groups. Donor and recipient variables were similar in the two groups. Episodes of PDF were numerically lower in the CS (2.4%) than UW group (7.8%), but the difference was not statistically significant. There was a trend toward a lesser need for early re-OLT (<30 days) in the CS group (P ‫؍‬ .0507), but again, no statistically significant difference emerged. Overall and time-differentiated postoperative deaths also were similar. One-year actuarial patient (UW, 89% v CS, 87%) and graft (UW, 83% v CS, 85%) survival rates were similar. In conclusion, CS was similar to UW solution as a preservation solution in the clinical setting of OLT at the infusion volumes described, although some theoretical advantages of CS composition suggest that CS might prove a valid alternative to UW preservation solution in multiorgan harvesting, including the liver. A study on a larger patient basis is needed. (Liver Transpl 2003;9:814-821.)

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mentioning

confidence: 99%

A multicenter pilot prospective study comparing Celsior and University of Wisconsin preserving solutions for use in liver transplantation

Cavallari

Cillo

Nardo

et al. 2003

Liver Transplantation

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“…In recent years several extracellular-type low-potassium solutions have been developed for improvement of pulmonary preservation by minimizing vasospasm, consequently leading to a more homogeneous distribution of the flush solution with superior functional results [4,5,6]. The lowpotassium dextran solution Perfadex especially is considered to significantly improve clinical results due to the beneficial effects of dextran [7,8].…”

Section: Commentmentioning

confidence: 99%

“…To improve the quality of pulmonary allograft preservation, alternative solutions have recently been developed. Promising results were obtained especially with the use of low-potassium solutions of extracellular electrolyte composition, which have significantly reduced the ischemia/reperfusion injury with excellent functional results in terms of postischemic oxygenation [4,5,6]. Currently, a growing number of lung transplantation centers switched their preservation regimen to Perfadex-based protocols, as this low-potassium dextran (LPD) solution (Perfadex) seems to be superior in terms of functional results as compared to standard preservation techniques in the past [7,8].…”

Section: Introductionmentioning

confidence: 99%

Impact of retrograde graft preservation in perfadex-based experimental lung transplantation

Wittwer

Franke

Fehrenbach

et al. 2004

Journal of Surgical Research

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“…The tests conducted show that Celsior improves the functioning of the right atrium of the transplanted heart in a significant manner, restoring heart action with a potentially lower risk of rejection. The conducted tests indicate that the solution may also be used to store the liver, kidneys, and lungs (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Influence of the Selected Antioxidants on the Stability of the Celsior Solution Used for Perfusion and Organ Preservation Purposes

Ostróżka-Cieślik

Dolińska

Ryszka³

2009

AAPS PharmSciTech

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Abstract. The purpose of the following research was to improve the original Celsior solution in order to obtain a higher degree of stability and effectiveness. The solution was modified by the addition of selected antioxidants such as vitamin C, cysteine, and fumaric acid in the following concentrations: 0.1, 0.3, and 0.5 mmol/l. The solution's stability was estimated using an accelerated stability test based on changes in histidine concentrations in the solution using Pauly's method for determining concentrations. Elevated temperatures, the factor accelerating substances' decomposition reaction rate, were used in the tests. The research was conducted at four temperatures at intervals of 10°C: 60±0.2°C, 70±0.2°C, 80±0.2°C, and 90±0.2°C. It was stated that the studied substances' decomposition occurred in accordance with the equation for first-order reactions. The function of the logarithmic concentration (log%C) over time was revealed to be rectilinear. This dependence was used to determine the kinetics of decomposition reaction rate parameters (the rate constant of decomposition k, activation energy E a , and frequency factor A). On the basis of these parameters, the stability of the modified solution was estimated at +5°C. The results obtained show that the proposed antioxidants have a significant effect on lengthening the Celsior solution's stability. The best results were reached when combining two antioxidants: vitamin C and cysteine in 0.5 mmol/l concentrations. As a result, the Celsior solution's stability was lengthened from 22 to 299 days, which is 13.5 times. Vitamin C at a concentration of 0.5 mmol/l increased the solution's stability by 5.2 times (t 90 =115 days), cysteine at a concentration of 0.5 mmol/l caused a 4.4 times stability increase (t 90 =96 days), and fumaric acid at a concentration of 0.5 mmol/l extended the stability by 2.1 times (t 90 =48 days) in relation to the original solution.

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A Comparison of the New Preservation Solution Celsior to Euro-Collins and University of Wisconsin Solutions in Lung Reperfusion Injury1

Cited by 51 publications

References 14 publications

A multicenter pilot prospective study comparing Celsior and University of Wisconsin preserving solutions for use in liver transplantation

A multicenter pilot prospective study comparing Celsior and University of Wisconsin preserving solutions for use in liver transplantation

Impact of retrograde graft preservation in perfadex-based experimental lung transplantation

Influence of the Selected Antioxidants on the Stability of the Celsior Solution Used for Perfusion and Organ Preservation Purposes

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