A Comparison of the Metabolism of Rubidium 86 and Potassium 42 Following Simultaneous Injection Into Man

Tyor, Malcolm P.; Eldridge, J. S.

doi:10.1097/00000441-195608000-00009

Cited by 12 publications

(3 citation statements)

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“…It would thus appear that rat skeletal muscle accumulates the alkali metals at equilibrium in a definite order of preference, cesium > rubidium > potassium. Data obtained in a number of recent studies with radioactive tracer doses of rubidium (14)(15)(16) or cesium (17) appear to imply somewhat similar conclusions. In these tracer experiments, although no significant amount of intracellular potassium was displaced by the administered ions, the latter accumulated in muscle, red cells and most viscera at tissue plasma concentration ratios equal to, or greater than, those for potassium.…”

Section: Discussionmentioning

confidence: 65%

Cation Accumulation by Muscle Tissue: The Displacement of Potassium by Rubidium and Cesium in the Living Animal12

Relman¹,

Lambie²,

Burrows³

et al. 1957

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 65%

Cation Accumulation by Muscle Tissue: The Displacement of Potassium by Rubidium and Cesium in the Living Animal12

Relman¹,

Lambie²,

Burrows³

et al. 1957

J. Clin. Invest.

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“…Rubidium behaves physiologically like potassium and permeates cell membranes freely (Burch, Threefoot, and Ray, 1955;Tyor and Eldridge, 1956). The time course of radioactivity in aortic and pancreatic venous blood following an injection of a bolus of 86Rb was similar in both the control and in the dogs infused with secretin.…”

Section: Discussionmentioning

confidence: 99%

Relationship between pancreatic secretion and pancreatic blood flow

Goodhead¹,

Himal²,

Zanbilowicz³

1970

Gut

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“…It is appropriate to examine the adjacent profile in the cells and to compare the two profiles. We find, from equation 2 The bulk of the trailing material is intracellular at the times being considered and the changes in cellular concentration which result with changes in the ratio k1/k2 are so little different that we have displayed them as a single common intracellular profile. When k1/k2 = 1.0 (i.e., when k2 is largest) the intravascular profile is largest in magnitude; and with increase in the ratio, the magnitude of the profile decreases progressively.…”

Section: Appendixmentioning

confidence: 93%

On the Uptake of Materials by the Intact Liver THE CONCENTRATIVE TRANSPORT OF RUBIDIUM-86

Goresky¹,

Bach²,

Nadeau³

1973

J. Clin. Invest.

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A B S T R A C T In this study we use the multiple indicator dilution technique to outline the kinetic mechanisms underlying the uptake of rubidium, a cation which, in the steady state, is concentrated by hepatic parenchymal cells. We inject a mixture of "1Cr-labeled red blood cells (a vascular reference substance), 'Na (which is confined to the extracellular space, the expected extravascular distribution space for rubidium, in the absence of cellular uptake), and 'Rb into the portal vein and obtain normalized outflow patterns, expressed as outflowing fractions of each injected mass per milliliter vs. time. The labeled red cell curve rises to the highest and earliest peak and decays rapidly. That for labeled sodium rises to a later and lower peak, and decays less rapidly. Its extrapolated recovery is equal to that for the red cells. The observed 'Rb curve consists of two parts: an early clearly defined peak of reduced area, related to the N'Na peak in timing; and a later tailing, obscured by recirculation, so that total outflow recovery cannot be defined (even though it would be expected to be the same). We model the concentrative uptake of 'Rb and find two corresponding outflow fractions: throughput material, which sweeps past the cell surface as a wave delayed with respect to the vascular reference (tracer which has not entered cells); and exchanging material (tracer which has entered cells and later returns to the circulation). We find that the outflow form of the rubidium curve, the presence of both a relatively clearly defined throughput component and a relatively prolonged low-in-magnitude tailing, is consequent to the concentrative character of the transport mechanism, to the presence of an influx rate constant many times the efflux rate constant. The modeling which we develop is general, and has potential application in situations where transport is nonconcentrative.

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A Comparison of the Metabolism of Rubidium 86 and Potassium 42 Following Simultaneous Injection Into Man

Cited by 12 publications

References 0 publications

Cation Accumulation by Muscle Tissue: The Displacement of Potassium by Rubidium and Cesium in the Living Animal12

Cation Accumulation by Muscle Tissue: The Displacement of Potassium by Rubidium and Cesium in the Living Animal12

Relationship between pancreatic secretion and pancreatic blood flow

On the Uptake of Materials by the Intact Liver THE CONCENTRATIVE TRANSPORT OF RUBIDIUM-86

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