A comparison of the mast cell and eosinophil responses of sheep and goats to gastrointestinal nematode infections

Huntley, John F.; Patterson, Margaret F.; Mackellar, A.; Jackson, F.; Stevenson, L.M.; Coop, R.L.

doi:10.1016/0034-5288(95)90080-2

Cited by 83 publications

(52 citation statements)

References 19 publications

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“…However, relatively little information exists on the cellular components of local immunity in goats (Huntley et al, 1995;Patterson et al, 1996a,b). In addition, they were mostly acquired with the genus Teladorsagia or Trichostrongylus.…”

Section: Discussionmentioning

confidence: 99%

“…At necropsy, histological samples were collected from both fundus and pylorus to count mast cells, globule leukocytes and eosinophils in the abomasal mucosa according to the technique described by Larsen et al (1994) and Huntley et al (1995). The stained cells were enumerated at 400× magnification using a calibrated graticule encompassing an area of 0.25 mm 2 .…”

Section: Blood and Histological Analysesmentioning

confidence: 99%

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Effects of condensed tannins on goats experimentally infected with Haemonchus contortus

Paolini

Bergeaud

Grisez

et al. 2003

Veterinary Parasitology

167

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Although the use of tanniferous plants or condensed tannins as an alternative to anthelmintics to control gastrointestinal nematodes has been largely documented in sheep, studies remain scarce in goats. The objective of this study was therefore to assess the possible impact of condensed tannins in goats infected with adult Haemonchus contortus. Two groups of cull goats were experimentally infected with 10.000 L3 of H. contortus. After 4 weeks, quebracho extracts, representing 5% of the diet DM, were administered for 8 days to one of the two groups. Goats of the second group remained as controls. One week after the end of quebracho administration, the goats were euthanised. Individual egg excretion and pathophysiological parameters were measured weekly during the study. At the end of the study, worm counts were assessed and histological samples from the abomasa were taken to count the numbers of mucosal mast cells, globule leukocytes and eosinophils. The administration of tannins was associated with a significant decrease in egg excretion, which persisted until the end of experiment. This reduction was not associated with any difference in worm number but with a significant decrease in female fecundity. No significant changes in the mucosal density of the three inflammatory cell types were detected between the two groups. These results indicate that the major consequence of tannin consumption in goats is a reduction in worm fecundity and egg output, which does not seem related to significant changes in the local mucosal response.

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Section: Discussionmentioning

confidence: 99%

Section: Blood and Histological Analysesmentioning

confidence: 99%

Effects of condensed tannins on goats experimentally infected with Haemonchus contortus

Paolini

Bergeaud

Grisez

et al. 2003

Veterinary Parasitology

167

View full text Add to dashboard Cite

show abstract

“…At necropsy, histological samples were collected from both fundus and pylorus and from the small intestine for determination of the number of mast cells, globule leukocytes and eosinophils in the mucosae according to the technique described by Larsen et al [15] and Huntley et al [9]. The stained cells were enumerated at a 400 magnification using a calibrated graticule encompassing an area of 0.25 mm 2 .…”

Section: Methodsmentioning

confidence: 99%

Effects of condensed tannins on established populations and on incoming larvae of Trichostrongylus colubriformis and Teladorsagia circumcincta in goats

et al. 2003

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-The use of tanniferous plants or tannins represents one alternative approach to the control of gastrointestinal parasites in ruminants but most data have been obtained in sheep. The current study was therefore performed in goats with two objectives: firstly, to investigate the effects of condensed tannins (CT) on adult populations of Trichostrongylus colubriformis and Teladorsagia circumcincta; secondly, to examine their effects on the establishment of infective larvae of these two species. In experiment 1, two groups of kids were infected with 6 000 L3 of T. colubriformis and 6 000 L3 of T. circumcincta. After 7 weeks, quebracho extracts were administered per os for 8 days to one group. A comparable group which did not receive tannins was included as the control. The kids were slaughtered on week 11. Parasitological and pathophysiological parameters were measured weekly. Worm counts were assessed and mast cells, globule leukocytes and eosinophils were counted in the abomasal and intestinal mucosae. Tannin administration was associated with a decrease in egg excretion, and a decrease in female fecundity, but with no changes in worm numbers. These changes were associated with an increased number of intestinal mast cells. In experiment 2, 24 goats were used according to a 2 ´ 2 factorial design, depending on infection and tannin administration. Two groups were either infected with 6 000 L3 of T. colubriformis or T. circumcincta. Within each group, the goats were either drenched or undrenched with tannin extracts. Pathophysiological parameters were measured weekly. Twelve days after the cessation of tannin administration, the goats were slaughtered. Worm counts and female worm fecundity were determined. Tannin consumption was associated with a significant reduction (P < 0.01) of Trichostrongylus populations and a close to significant reduction for Teladorsagia. No effect on fecundity was observed. Our results (1) confirm the consequences of condensed tannins on nematodes in goats as in sheep and (2) indicate divergent effects depending on the parasitic stage exposed to the condensed tannins.Trichostrongylus colubriformis / Teladorsagia circumcincta / goat / tannin / alternative methods of control

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“…In order to obtain a more sustainable control of these parasitic diseases, recent suggestions have been debated and proposed which take into consideration these differences by restricting treatments to the youngest animals of the flock in cattle [72] or sheep [46]. In goats, a lower divergence exists in the level of infection between young and adult goats which probably reflects the low ability of goats to develop an immune response against gastrointestinal nematodes [27,37]. Some observations obtained from natural infections indicate that adult goats are more infected than kids [58] but others find that the opposite is true [56].…”

Section: Identification Of Less Resistant Animals In Relation With Agementioning

confidence: 99%

Control of gastrointestinal parasitism with nematodes in dairy goats by treating the host category at risk

Hoste¹,

Chartier

Frileux

2002

Vet. Res.

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-Infections of the gastrointestinal tract with parasitic nematodes remain one of the main limiting factors in grazing dairy goats. The usual mode of control of these parasitic diseases has up to now been based on the repeated use of anthelmintics. However, the prevalence rates of anthelmintic resistances, in particular to benzimidazoles, are now particularly high in the French dairy goat production. This situation makes it mandatory to reconsider the usual mode of control of these nematodes and to look for short term, alternative solutions which combine the control of gastrointestinal infections and management of anthelmintic resistances. One of the possible options is to leave a part of the flock without treatment during the grazing season in order to maintain alleles of susceptibility to anthelmintics within the worm populations. Previous epidemiological observations identifying the categories of host populations at risk are presented which provide the rationale for targeted applications of treatments. The results of assays on experimental flocks and from farm surveys examining the advantages and drawbacks of selective treatments are presented. The value of these results in combination with other alternative solutions of control are discussed in order to use minimum treatments with maximum benefits. dairy goat / anthelmintic / selective treatment / anthelmintic resistance / parasitic nematode Résumé -Maîtrise des strongyloses gastro intestinales chez les chèvres laitières par l'application de traitements ciblés. Les infestations par les nématodes du tractus gastro intestinal demeurent un des principaux facteurs limitant à l'élevage des chèvres laitières au pâturage. Le mode usuel de maîtrise de ce parasitisme reposait jusqu'à présent sur un usage répété de molécules anthelminthiques. Cependant, la prévalence des lignées résistantes aux anthelminthiques, en particulier aux benzimidazoles, en éle-vage caprin laitier en France, est désormais très élevée. Ce constat oblige à rechercher rapidement des 531

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A comparison of the mast cell and eosinophil responses of sheep and goats to gastrointestinal nematode infections

Cited by 83 publications

References 19 publications

Effects of condensed tannins on goats experimentally infected with Haemonchus contortus

Effects of condensed tannins on goats experimentally infected with Haemonchus contortus

Effects of condensed tannins on established populations and on incoming larvae of Trichostrongylus colubriformis and Teladorsagia circumcincta in goats

Control of gastrointestinal parasitism with nematodes in dairy goats by treating the host category at risk

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