A Comparison of the Low-Level Laser Versus Low Intensity Pulsed Ultrasound on New Bone Formed Through Distraction Osteogenesis

Koçyiğit, İsmail; Coşkunses, Fatih Mehmet; Pala, Elvan; Tuğcu, Funda; Önder, M. Ercüment; Mocan, Asriye

doi:10.1089/pho.2012.3263

Cited by 19 publications

(19 citation statements)

References 45 publications

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“…LIPUS is a safe therapeutic technique that has been successfully used in sports medicine field, primarily for fractured bone healing (Bashardoust Tajali, Houghton, MacDermid, & Grewal, 2012) or distraction osteogenesis (El-Bialy et al, 2002;El-Bialy, Elgazzar, Megahed, & Royston, 2008;Kocyigit et al, 2012;Salem and Schmelz, 2014). In the orthodontic field, LIPUS has also been proven to enhance tooth regeneration in animals undergoing mandibular distraction osteogenesis (El-Bialy, El-Moneim Zaki, & Evans, 2003).…”

Section: Discussionmentioning

confidence: 99%

Effect of low-intensity pulsed ultrasound on the activity of osteoclasts: An in vitro study

Feres

Kucharski

Diar-Bakirly

et al. 2016

Archives of Oral Biology

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Section: Discussionmentioning

confidence: 99%

Effect of low-intensity pulsed ultrasound on the activity of osteoclasts: An in vitro study

Feres

Kucharski

Diar-Bakirly

et al. 2016

Archives of Oral Biology

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“…Of which, 31 studies were eliminated after reviewing the abstracts which clearly showed these papers did not meet the criteria. Of the 19 potentially eligible articles retrieved in full text [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28], 2 were excluded as they used high intensity ultrasound (2 W/cm 2 ) [27,28] and 2 studies were published in 2 articles each and were thus considered as one study for the purpose of the research [11,12,23,24], leaving 15 eligible studies included in the systematic review (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…All studies used the pulsed technique exclusively, except for one study which compared the pulsed technique with continuous ultrasound treatment [22]. One study compared the effect of lowlevel laser versus LIPUS on rabbit mandible [26].…”

Section: Resultsmentioning

confidence: 99%

Low Intensity Pulsed Ultrasound for Accelerating Distraction Osteogenesis: A Systematic Review of Experimental Animal Studies

Ginini¹,

Shilo²,

Emodi³

et al. 2018

J. Mol. Clin. Med.

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The purpose of this report is to review systematically all studies performed regarding the influence of low intensity pulsed ultrasound (LIPUS) on bone regeneration in animals during distraction osteogenesis (DO). Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist structure, a systematic search using PubMed and EMBASE electronic databases was undertaken utilizing the key words "distraction osteogenesis" and "low intensity ultrasound". Human trials, review articles, case reports and non-English language publications were excluded. Data items were extracted from each eligible study, regarding the study design, risk of bias, results and whether or not LIPUS accelerated bone regeneration. The search identified 40 relevant articles, 15 of which were included for full review. Included studies were characterized by a high risk of bias and considerable variations in study design was observed. However, most studies which reported LIPUS in an intensity of 30-40 mW/cm 2 accelerated bone formation via endochondral ossification, thus shortening the consolidation period when applied during distraction and early consolidation periods. According to the current review, application of LIPUS during DO shows promise in accelerating bone formation and density during DO, that bears no adverse effects, thus shortening the consolidation period. Optimal timing of LIPUS application is during the distraction and early consolidation phases. The preferred intensity should be between 30-40 mW/cm 2. Histological analysis indicates influence via endochondral ossification. Thus, the effect of LIPUS on chondrocytes should be further investigated in order to decipher the exact molecular and cellular influence of LIPUS on enhancement of bone formation. These findings should be used in future clinical protocols and raise potential directions for future research regarding the molecular mechanisms underlying the influence of LIPUS on bone formation.

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“…For these reasons, numerous techniques, methods, and materials have been researched to accelerate the maturation of regenerated bone, including hormones, calcium sulphate, growth factors, and electronic and ultrasonic stimulation. 3,4 Osteoblastic cells, which are bone formative, and osteoclastic cells, which are bone resorptive, are both vital to DO. Together, the formation and resorption of bone tissue are known as bone remodelling.…”

Section: Declaration Of Interestsmentioning

confidence: 99%

“…This process is actualized when osteoblasts and osteoclasts work together physiologically. 1,2,3,4,5 In practice, the bone tissue remodelling mechanism is organized by the activity of systemic hormones (melatonin, oestradiol, parathyroid, and growth hormones), as well as by bone marrow and osteoid matrix-derived growth factors. Of particular interest among these systemic hormones is melatonin, because of its osteoblastic activity.…”

Section: Declaration Of Interestsmentioning

confidence: 99%

Systemic melatonin application increases bone formation in mandibular distraction osteogenesis

et al. 2018

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This study aimed to investigate the effects of different doses of systemic melatonin application on new bone formation during mandibular distraction osteogenesis (DO) in rats. Mandibular DO was performed on 30 adult female Sprague-Dawley rats, which were randomly divided into three groups: control group (CNT), melatonin dose 1 (MLT-D1), and melatonin dose 2 (MLT-D2). A five-day latent waiting period and a ten-day distraction phase followed the surgery. After the surgery, rats from the MLT-D1 and MLT-D2 groups received 25 and 50 mg/kg melatonin, respectively, at 7, 14, 21, 28, and 35 days. The animals were euthanised 28 days after distraction, i.e. at 43 days after surgery. Histological and histomorphometric analyses revealed that the distracted bone area was completely filled with new bone formation in all three groups. The MLT-D2 group exhibited the most new bone formation, followed by MLT-D1 and CNT. The melatonin groups had more osteoclasts than the CNT (p < 0.05). The number of osteoblasts was higher in the melatonin groups than in the CNT group, and the MLT-D2 had more osteoclasts than the MLT-D1 group (p < 0.05). Finally, the osteopontin (OPN) and vascular endothelial growth factor (VEGF) levels were higher in the melatonin groups than in the CNT group, and the MLT-D2 had higher OPN and VEGF levels than the MLT-D1 (p < 0.05). This study suggests that systemic melatonin application could increase new bone formation in DO.

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A Comparison of the Low-Level Laser Versus Low Intensity Pulsed Ultrasound on New Bone Formed Through Distraction Osteogenesis

Abstract: LIPUS and LLLT applied during the distraction period accelerated the DO treatment.

Cited by 19 publications

References 45 publications

Effect of low-intensity pulsed ultrasound on the activity of osteoclasts: An in vitro study

Effect of low-intensity pulsed ultrasound on the activity of osteoclasts: An in vitro study

Low Intensity Pulsed Ultrasound for Accelerating Distraction Osteogenesis: A Systematic Review of Experimental Animal Studies

Systemic melatonin application increases bone formation in mandibular distraction osteogenesis

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