A comparison of the influence of alpha-estradiol dipropionate and of estradiol cyclopentylpropionate on the vaginal mucosa of nonmenstruating and irregularly menstruating women

Shearman, Ann M.; McGavack, Thomas H.

doi:10.1016/0002-9378(53)90300-7

Cited by 5 publications

(4 citation statements)

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“…Estradiol dipropionate (EDP), which is a human pharmaceutical, exhibited prolonged estradiol-17β effects compared with EB and EV in rats [ 5 ] and humans [ 6 ]. Our previous study showed that a single administration of EDP at 12 days after the onset of estrus could also induce pseudopregnancy in gilts and plasma estradiol-17β concentrations in pseudopregnant gilts were maintained at high levels for 9 days after EDP treatment [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

An efficient protocol for inducing pseudopregnancy using estradiol dipropionate and follicular development associated with changes in reproductive hormones after prostaglandin F2alpha treatment in pseudopregnant sows

Noguchi

Yoshioka

Suzuki

et al. 2011

Reprod Biol Endocrinol

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BackgroundUtilization of estrus synchronization program in livestock industry would provide greater options for reproductive management in herd. To develop a convenient method for estrus synchronization in pigs, we determined the effective protocol using estradiol dipropionate (EDP) for the establishment of pseudopregnancy and investigated follicular development during the estrus synchronization with prostaglandin F2alpha (PGF2alpha) in association with reproductive hormone profiles in pseudopregnant sows.MethodsIn Experiment 1, the effective dose (0, 10, 20, or 30 mg) and timing (5, 8, 11 or 13 days after ovulation) of a single administration of EDP in cyclic pigs for the induction of pseudopregnancy were investigated. In Experiment 2, four pseudopregnant sows were treated with PGF2alpha twice at a 24-h interval between 24 and 28 days after EDP treatment. The changes in plasma concentrations of reproductive hormones were analyzed by time-resolved fluoroimmunoassay. Follicular development and ovulation following PGF2alpha administration were monitored by transrectal ultrasonography.ResultsHigh efficiency (greater than 80%) of pseudopregnancy was achieved with a single treatment with 20 mg of EDP at 8 and 11 days after ovulation (equivalent to 9-13 days after the onset of estrus). Plasma estradiol-17beta concentrations in pseudopregnant sows were significantly higher between 12 h and 7 days than before EDP treatment. Total inhibin concentrations significantly decreased following EDP treatment and remained low for 14 days. The number of small follicles was increased from 6.3 +/- 2.6 at PGF2alpha treatment to 22.8 +/- 4.8 at 3 days later; this was associated with increased plasma concentrations of inhibin. Onset of estrus was detectable in all sows on 5.3 +/- 0.3 days after PGF2alpha treatment and the number of ovulated follicles was 15.5 +/- 1.4 detected at 7.6 +/- 0.2 days after the treatment.ConclusionsThis study has defined the effective dose and timing of EDP treatment for inducing pseudopregnancy in cyclic pigs. Our results also indicated that EDP caused a lowering of inhibin concentrations during pseudopregnancy and small numbers of follicles from 20 to 28 days after EDP. In contrast, EDP-induced pseudopregnancy appears to have no adverse effect on follicular development and subsequent ovulation following PGF2alpha administration.

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Section: Introductionmentioning

confidence: 99%

An efficient protocol for inducing pseudopregnancy using estradiol dipropionate and follicular development associated with changes in reproductive hormones after prostaglandin F2alpha treatment in pseudopregnant sows

Noguchi

Yoshioka

Suzuki

et al. 2011

Reprod Biol Endocrinol

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“…It has been reported that daily injection of estradiol benzoate (EB) from days 11 to 14 [9] of the estrous cycle or estradiol valerate (EV) from days 11 to 15 [27] can induce pseudopregnancy. We previously showed that a single administration of estradiol dipropionate (EDP), which exhibited prolonged estradiol-17β effects compared with EB and EV in rats [14] and humans [22], at 9 − 13 days after the onset of estrus could also induce pseudopregnancy in gilts and sows [17,18]. Administration of EDP appears to be more effective for inducing pseudopregnancy in females in terms of effort and cost compared with the previous method of using at least 4 administrations of EB or EV [7,9,27].…”

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confidence: 99%

Reproductive Hormone Profiles in Sows on Estrus Synchronization using Estradiol Dipropionate and Prostaglandin F<sub>2α</sub>-Analogue and the Reproductive Performance in Female Pigs on Commercial Farms

Noguchi

Kashiwai

Itoh

et al. 2013

The Journal of Veterinary Medical Science

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ABSTRACT. Changes in ovarian structures and hormonal profiles in estradiol dipropionate (EDP)-induced pseudopregnant sows following PGF 2α -analogue (PGF 2α -A) administration and practicality of the estrus synchronization protocol using EDP and PGF 2α -A on estrus expression and reproductive performance in commercial conditions were investigated. Pseudopregnancy was defined as absence of estrus maintained for at least 20 days after EDP treatment in this study. When 4 pseudopregnant sows induced by 20 mg EDP were treated with PGF 2α -A as 0.175 mg cloprostenol twice at a 24-hr interval between 20 and 28 days after EDP treatment, plasma progesterone concentrations rapidly decreased after treatment. The luteinizing hormone surge and ovulation were detected in all sows. The number of ovulated follicles was 17.3 ± 1.1 (SEM). On commercial farms, 94.2% of 52 gilts and 95.2% of 21 sows received EDP became pseudopregnant. When these pseudopregnant females (48 gilts and 20 sows) were treated with PGF 2α -A as described above, estrus was detected in all females at 6.1 ± 0.3 days for gilts and 5.5 ± 0.2 days for sows after the first PGF 2α -A treatment. There were no significant differences in farrowing rate (85.0 − 100%), average total litter size (10.0 − 11.4), average born alive litter size (9.4 − 10.3) and average piglet birth weight (1.56 − 1.71 kg) between PGF 2α -A treated pseudopregnant female pigs that were inseminated during synchronized estrus and females inseminated during spontaneous estrus. This study indicates that estrus synchronization programs using EDP and PGF 2α -A are available as practical and convenient procedures for commercial pig farms.

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“…Compared with EB, EDP exhibits a low threshold value with a relatively intense and prolonged effect in rats [21] and humans [22]. However, there have been no reports of using EDP to induce pseudopregnancy in swine.…”

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confidence: 99%

Estrus Synchronization with Pseudopregnant Gilts Induced by a Single Treatment of Estradiol Dipropionate

et al. 2010

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Abstract. The aims of this study were to determine whether a single treatment of estradiol dipropionate (EDP) could induce pseudopregnancy in gilts and to determine the effectiveness of PGF2α treatment on estrus synchronization in EDP-induced pseudopregnant gilts. In experiment 1, gilts were treated with 20 mg of EDP (n=11) or vehicle (n=5) on Day 12 (Day 0=onset of estrus). Establishment of pseudopregnancy was defined as a lack of estrus and maintenance of the plasma progesterone concentration above 1 ng/ml between Days 12 and 36. Nine of 11 gilts (82%) treated with EDP became pseudopregnant. The plasma estradiol-17β level was significantly higher in the EDP-treated gilts than in the control gilts until Day 29. In experiment 2, PGF2α was administered twice with a 24-h interval from Day 36 in pseudopregnant gilts (n=6) or Day 10 in cyclic gilts (control; n=5). Estrus after PGF2α treatment was observed in 83% of the pseudopregnant gilts. The interval from the day of the first PGF2α treatment to the onset of estrus and the peak of the LH surge was significantly shorter in the pseudopregnant gilts than in the control gilts. In experiment 3, six pseudopregnant gilts were bred by artificial insemination at the estrus after PGF2α treatment. The farrowing rate and average litter size did not differ between the PGF2α-treated pseudopregnant and cyclic gilts. These results indicate that a single treatment of EDP on Day 12 of the estrous cycle can induce pseudopregnancy in pigs and that a convenient protocol for administering PGF2α to EDP-induced pseudopregnant pigs is available for estrus synchronization programs in cyclic pigs. Key words: Estradiol dipropionate, Estrus control, Pig, Pseudopregnancy (J. Reprod. Dev. 56: [421][422][423][424][425][426][427] 2010) t is desirable to have female pigs in estrus at certain times to provide maximum use of intensive pork production facilities. Application of estrus synchronization programs enhances economic performance in the swine industry by reducing the labor required to detect estrus, facilitating the use of artificial insemination (AI) and assisting in batch farrowing. Therefore, being able to control the time of estrus in a breeding herd results in decreased reproductive efforts and costs.Artificially shortening or extending the luteal phase is important for control of the interestrous interval in cyclic animals. The corpus luteum (CL) of the cycling pig generally exhibits resistance to prostaglandin F2α (PGF2α)-induced luteolysis prior to Day 12 of the estrous cycle [1][2][3]. Consequently, multiple administrations of PGF2α in the early luteal phase are required to induce luteolysis of the functional CL and shorten the estrous cycle [2,3]. In contrast to the CL before Day 12 of the estrous cycle, the CL of the pregnant pig easily reacts to exogenous administration of PGF2α [4,5], and prompt estrus can be induced between 4 and 7 days after PGF2α treatment; however, exogenous administration of PGF2α is associated with abortion in pregnant pigs [4,6].In pigs, two phases of ...

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A comparison of the influence of alpha-estradiol dipropionate and of estradiol cyclopentylpropionate on the vaginal mucosa of nonmenstruating and irregularly menstruating women

Cited by 5 publications

References 2 publications

An efficient protocol for inducing pseudopregnancy using estradiol dipropionate and follicular development associated with changes in reproductive hormones after prostaglandin F2alpha treatment in pseudopregnant sows

An efficient protocol for inducing pseudopregnancy using estradiol dipropionate and follicular development associated with changes in reproductive hormones after prostaglandin F2alpha treatment in pseudopregnant sows

Reproductive Hormone Profiles in Sows on Estrus Synchronization using Estradiol Dipropionate and Prostaglandin F<sub>2α</sub>-Analogue and the Reproductive Performance in Female Pigs on Commercial Farms

Estrus Synchronization with Pseudopregnant Gilts Induced by a Single Treatment of Estradiol Dipropionate

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