A comparison of the immunostimulatory effects of the medicinal herbs Echinacea, Ashwagandha and Brahmi

Yamada, Koji; Hưng, Phạm Văn; Park, Tae Kyu; Park, Pyo Jam; Lim, Beong Ou

doi:10.1016/j.jep.2011.05.017

Cited by 54 publications

(37 citation statements)

References 23 publications

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“…The information from the literature published to date is limited and the mechanism modifying the immune system is not well-known. Echinacea may have immunostimulant effects, such as increasing cytokine and immunoglobulin (Ig) production (7,8). Unsaturated N-alkylamide lipids, the main constituent of echinacea, have been suggested to play a role as potential anti-inflammatory and proinflammatory effects (9,10).…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that echinacea alkylamides modulate tumor necrosis factor alpha (TNF-α) gene expression via cannabinoid receptor type 2 (CB2) and multiple signal transduction pathways (9). Some experimental studies have shown that TNF-α expression was higher in animals who received diet containing echinacea, while some showed lower TNF-α production in echinacea-fed animals (8,11). Yamada et al (8) observed increased cytokine (IL-2 and interferon gamma) production from T helper 1 cells with dietary echinacea and significant increases in the serum IgG level and all Ig production in the spleen.…”

Section: Discussionmentioning

confidence: 99%

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Acute Disseminated Encephalomyelitis after Oral Therapy with Herbal Extracts: A Case Report

et al. 2016

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Background: Acute disseminated encephalomyelitis (ADEM) is a rare demyelinating disease of the central nervous system, commonly attributed to infections or vaccinations. Toxic or allergenic compounds can also trigger a response in the immune system and may cause demyelination. We present a case with ADEM after using oral herbal medications. Case Report: A 25 year-old male developed bilateral central facial palsy and severe quadriparesis after taking herbal drugs (containing echinacea and many other herbal ingredients) for two weeks. He had used the extract to increase his potency and reproductivity. He had no past history of recent immunization or viral infection. The clinical findings, cerebrospinal fluid (CSF) analysis and brain magnetic resonance imaging (MRI) were compatible with ADEM. The neurological findings were improved after seven doses of pulse methylprednisolone treatment. To our knowledge, this is the third report in the literature that links herbal therapy and demyelinating disease. Conclusion: Most of the ADEM cases related to herbal therapy in the literature similarly used echinacea. It is our opinion that other ingredients of the herbal extract used by our case, besides echinacea, could have the potential to cause a trigger in the immune system. Further studies are needed to clarify the immunological effects of different kinds of herbal compounds, as well as the effects of different parts of the plants and the results of various dosages. Moreover, ingredients should also be tested for toxicity, adverse effects and drug interactions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acute Disseminated Encephalomyelitis after Oral Therapy with Herbal Extracts: A Case Report

et al. 2016

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“…Overall, the humoral immunity of animals after administration of the Biofield Energy Treated test formulation was altered, which might be due to the constituents of the test formulation such as ashwagandha [34,35] and minerals such as zinc, selenium, and magnesium [36] have been reported for beneficial effect of immune function. Thus, the results exhibited significant alteration in the levels of IgG and IgM in the Biofield Energy Treated test formulation as compared with the disease control and untreated test formulation.…”

Section: Figure 1 Effect Of the Test Formulation On (A) Igm And (B) mentioning

confidence: 99%

Impact of Biofield Energy Treated (The Trivedi Effect®) Herbomineral Formulation on the Immune Biomarkers and Blood Related Parameters of Female Sprague Dawley Rats

Trivedi¹,

Branton²,

Trivedi³

et al. 2017

AJLS

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Abstract:The aim of the present study was to evaluate the immunomodulatory potential of Biofield Energy Treatment (The Trivedi Effect ® ) on a new proprietary compound composed of herbs and minerals (herbomineral formulation). The test formulation contains the mixture of the herbal root extract ashwagandha and the minerals (zinc, magnesium, and selenium). The test formulation was divided into two parts. One part was denoted as the control without any Biofield Energy Treatment, while the other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment remotely from eighteen renowned Biofield Energy Healers and defined as the Biofield Energy Treated formulation. The immunomodulatory parameters viz. humoral immune response (IgG and IgM), cellular immune response (CD4 + /CD8 + ), hematological parameters, lipid profile, hepatic enzymes, and sex hormones (progesterone and estrogen) in female Sprague Dawley rats were analyzed. The results of humoral immune response data showed decreased levels of IgG and IgM by 80.54% and 78.94% respectively, in the Biofield Energy Treated test formulation group (G3) compared with the disease control group (G2). Estimation of cellular immune response data revealed a significant (p≤0.01) increase in the ratio of CD4 + /CD8+ by 161.71% in the G3 group, while it was increased by 100.50% in the untreated test formulation group (G4) compared with the G2 group. Thus, the humoral and cellular immune responses were significantly altered in the G3 as compared with the G4 group. The TLC and neutrophils counts were significantly increased by 11.34% and 1.34% respectively, in the G3 compared with the G2 group. Lipid profile data suggested that the Biofield Energy Treated test formulation showed improvement in the tested parameters compared with the untreated test formulation group. However, significant improvement was found in the tested hepatic biomarkers i.e. decreased levels of the SGOT, SGPT, and CK-MB by 14.28%, 8.54%, and 20.79% in the G3 group compared with the G2 group. The levels of total protein, alkaline phosphatase, albumin, and globulin were increased by 11.93%, 1.24%, 6.10%, and 20.74% respectively, in the G3 compared with the G2 group. Consequently, the levels of progesterone and estrogen were significantly increased by 199.86% and 50.19%, respectively in G3 with respect to the G2 group. In conclusion, overall data suggest that The Trivedi Effect ® -Biofield Energy Healing Treatment on the herbomineral formulation can be used for autoimmune and inflammatory diseases, stress management, and anti-aging by improving overall health.

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“…Additionally, the levels of IgM and IgG were reduced by 28.57% and 13.39%, respectively in the positive control (levamisole) group (G5) compared with the G2. Yamada et al had reported that ashwagandha enhance the immune function by increasing immunoglobulin production [36]. Experimental studies reported that an influence of zinc nutriture on the balance between lymphocyte TH1 elements and functions (cell-mediated immunity) and TH2 elements and functions (humoral immunity).…”

Section: Measurement Of Humoral Responsesmentioning

confidence: 99%

Evaluation of Immune Biomarkers After Oral Administration of Biofield Energy Healing Based Herbomineral Formulation in Male Sprague Dawley Rats

Trivedi¹

2017

IJBBMB

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Abstract:The natural products based formulations usage have been increased world-wide in health care sector due to their high safety and better therapeutic action. A new proprietary herbomineral formulation was formulated with four ingredients; a mixture of the minerals (zinc, magnesium, and selenium) and the herbal root extract ashwagandha. The aim of the study was to evaluate the immunomodulatory potential of Biofield Energy Healing (The Trivedi Effect ® ) on the herbomineral formulation in male Sprague Dawley (SD) rats. The test formulation was divided into two parts. One part was denoted as the control without any Biofield Energy Treatment, while the other part was defined as the Biofield Energy Treated sample, which received the Energy of Consciousness Healing Treatment remotely from eighteen renowned Biofield Energy Healers. The immunomodulatory effect of the Biofield Energy Treated and untreated test formulations was studied in SD rats to determine any alteration in humoral immune response (IgG and IgM), cellular immune response, hematological parameters, lipid profile, hepatic enzymes, and the sex hormone (testosterone). The ratio of CD4 + /CD8 + was significantly increased by 51.98% and 12.99% (p≤0.05) in the Biofield Energy Treated (G3) and untreated test formulations (G4), respectively compared with the disease control group (G2). The level of IgM was significantly increased by 28.57% in the G3 group, while decreased by 14.29% in the G4 group compared with the G2 group. The eosinophil count was significantly increased by 27.27% in the G3 group, while decreased by 18.18% in the G4 group compared with the G2 group. The levels of triglycerides (TG) and very low density lipoproteins (VLDL) were reduced by 8.99% and 9.12%, respectively in the G3 group compared with the G2 group. However, the levels of TG and VLDL were reduced by 2.40% and 3.46%, respectively in the G4 group compared with the G2 group. Among the tested hepatic parameters, results showed decreased levels of serum glutamate oxaloacetate transaminase (SGOT) and creatine kinase myocardium band (CK-MB) by 42.65% (p<0.01) and 7.67%, respectively in the Biofield Energy Treated test formulation group (G3) compared to the G2 group. The level of testosterone was significantly increased by 22.02% in the G3 group compared with G2 group. The overall results demonstrated that the Biofield Energy Treated test formulation showed better immune response compared with the untreated test formulation. These data suggest that the Biofield Energy Treated test formulation can be used for autoimmune and inflammatory diseases, stress management and anti-aging by

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A comparison of the immunostimulatory effects of the medicinal herbs Echinacea, Ashwagandha and Brahmi

Cited by 54 publications

References 23 publications

Acute Disseminated Encephalomyelitis after Oral Therapy with Herbal Extracts: A Case Report

Acute Disseminated Encephalomyelitis after Oral Therapy with Herbal Extracts: A Case Report

Impact of Biofield Energy Treated (The Trivedi Effect<sup>®</sup>) Herbomineral Formulation on the Immune Biomarkers and Blood Related Parameters of Female <i>Sprague Dawley</i> Rats

Evaluation of Immune Biomarkers After Oral Administration of Biofield Energy Healing Based Herbomineral Formulation in Male <i>Sprague Dawley</i> Rats

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A comparison of the immunostimulatory effects of the medicinal herbs Echinacea, Ashwagandha and Brahmi

Cited by 54 publications

References 23 publications

Acute Disseminated Encephalomyelitis after Oral Therapy with Herbal Extracts: A Case Report

Acute Disseminated Encephalomyelitis after Oral Therapy with Herbal Extracts: A Case Report

Impact of Biofield Energy Treated (The Trivedi Effect&lt;sup&gt;®&lt;/sup&gt;) Herbomineral Formulation on the Immune Biomarkers and Blood Related Parameters of Female &lt;i&gt;Sprague Dawley&lt;/i&gt; Rats

Evaluation of Immune Biomarkers After Oral Administration of Biofield Energy Healing Based Herbomineral Formulation in Male &lt;i&gt;Sprague Dawley&lt;/i&gt; Rats

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Product

Resources

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Impact of Biofield Energy Treated (The Trivedi Effect<sup>®</sup>) Herbomineral Formulation on the Immune Biomarkers and Blood Related Parameters of Female <i>Sprague Dawley</i> Rats

Evaluation of Immune Biomarkers After Oral Administration of Biofield Energy Healing Based Herbomineral Formulation in Male <i>Sprague Dawley</i> Rats