A Comparison of the Handling and Accuracy of Syringe and Vial Versus Prefilled Insulin Pen (FlexPen)

Asakura, Takeshi; Seino, Hiroaki; Nakano, R; Muto, Toshio; Toraishi, Kenichi; Sako, Yasuhiro; Kageyama, Miho; Yohkoh, Noriaki

doi:10.1089/dia.2009.0006

Cited by 53 publications

(36 citation statements)

References 7 publications

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“…35 The present test expands on this, not only showing that this preference exists among patients with different levels of impaired manual dexterity, but also showing preference for NovoTwist versus a variety of other needles. Previous studies have shown that among users of insulin injection pens most preferred the use of Next Generation FlexPen, [27][28][29][30][31]35,37 and the introduction of the NovoTwist needle is likely to increase patient preference for this system. However, no attempt was made in this test to determine how important needle preference may be in overall patient preference for pen-needle systems.…”

Section: Discussionmentioning

confidence: 99%

Needle with a Novel Attachment Versus Conventional Screw-Thread Needles: A Preference and Usability Test Among Adults with Diabetes and Impaired Manual Dexterity

Hansen

Lilleøre²,

Ter-Borch³

2011

Diabetes Technology & Therapeutics

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Background: NovoTwist Ò (Novo Nordisk A/S, Bagsvaerd, Denmark) is an insulin pen needle that features a novel attachment and detachment system. The aim of this test was to assess overall preference and handling of NovoTwist compared with conventional screw-thread needles in people with type 1 or type 2 diabetes. Methods: One hundred twenty adults with type 1 or type 2 diabetes and manual dexterity dysfunction who were currently self-injecting with an insulin pen were included in this open-label, randomized, crossover test. Participants were stratified according to the impact that manual dexterity problems had on their ability to inject insulin (1 ¼ no effect at all; 4 ¼ a lot), and those rated as 1 were excluded from subanalyses because of low numbers. Following instruction, participants attached the needle to Next Generation FlexPen Ò (Novo Nordisk A/S), made an injection into a foam cushion, and detached the needle; this process was repeated three times with NovoTwist and the participant's current screw-thread needle (or NovoFine Ò [Novo Nordisk A/S]) in a random order. Responses to questions on user experience with each needle were subsequently recorded on a 6-point rating scale (1 ¼ very difficult; 6 ¼ very easy). Results: Significantly more respondents had a preference for NovoTwist (79%) compared with the conventional screw-thread needles (21%, P < 0.001). Significantly more respondents preferred NovoTwist for both ease of attachment (80%, P < 0.001) and ease of detachment (74%, P < 0.001). Most respondents found NovoTwist the most appropriate needle for performing everyday injections (71%, P < 0.001). Conclusions: Such preference by patients has a positive impact on the treatment of diabetes as NovoTwist may alleviate the burden of performing everyday injections through its ease of use.

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Section: Discussionmentioning

confidence: 99%

Needle with a Novel Attachment Versus Conventional Screw-Thread Needles: A Preference and Usability Test Among Adults with Diabetes and Impaired Manual Dexterity

Hansen

Lilleøre²,

Ter-Borch³

2011

Diabetes Technology & Therapeutics

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“…17,18 Pen injectors have been routinely used for treatment of diabetes since the 1980s and, since reports showed superior pen injector accuracy compared with vials and syringes, have undergone a continual process of refinement to improve ease of use. [19][20][21] To ensure safe and effective use of pen injectors by patients, a number of key considerations must be incorporated in their design and development, including physical aspects such as the range of patient hand size, mobility, dexterity, coordination, flexibility, strength, and stamina. Furthermore, various sensory capacities (including vision and tactile sensitivities) as well as cognitive aspects (including the ability and willingness of patients to adapt to new devices) have to be considered.…”

mentioning

confidence: 99%

Usability of the Novel Liraglutide 3.0 mg Pen Injector Among Overweight or Obese Adult Patients With or Without Prior Injection Experience

Fujioka

Sparre

Sun

et al. 2015

J Diabetes Sci Technol

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Obesity is a chronic disease often encompassed by a multitude of serious comorbidities, making its prevention and treatment public health priorities. Globally, by 2030, the numbers of adults who are overweight ( It has been shown that an increase in BMI is directly correlated with a reduction in life expectancy and increase in obesity-related comorbidities such as type 2 diabetes mellitus (T2DM).3-5 A 5-10% weight loss can provide clinically relevant improvements in obesity-related comorbidities and quality of life (QoL).6,7 Depending on BMI classification and the number/severity of comorbidities, behavioral therapy including dietary and physical activity changes, pharmacotherapy and (in the appropriate patient) bariatric surgery are recommended. 8,9 However, achieving and maintaining weight loss by diet and physical activity alone can be challenging.10-12 Pharmacotherapy supports weight loss and Background: Obesity is associated with multiple comorbidities and increased mortality, making it an important target for treatment. However, achieving and maintaining weight loss by diet and physical activity remains challenging, and may often require pharmacotherapy. Liraglutide 3.0 mg has recently been approved for weight management in the United States, Canada, and EU. The current analysis used a summative usability test to assess safety and effectiveness, ease of use, and training requirements for the novel liraglutide 3.0 mg pen injector.

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“…The more accurate modern insulin delivery deThe more accurate modern insulin delivery deThe more accurate modern insulin delivery de� vices, pens, Microfine , pens, Microfine ® , PenMate ® and �utocover �utocover ® , have have redefined parents expectations [4] . �ow, mixing is rarely �ow, mixing is rarely acceptable since it is not as accurate or reliable as pens [7] . Mixing and diluting insulin share the inconvenience of carrying the unsightly syringes and needles around, es� pecially on holidays.…”

Section: Letters To the Editormentioning

confidence: 99%

Toddlers’ choice: Yo-Yoing diabetes control or deci-unit insulin dosing?

Abul-Ainine

Abul-Ainine²

2012

WJD

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While the incidence of toddlers' diabetes is soaring, their mainstay insulins were withdrawn, namely the weak 10% or 20% insulin mixtures (WIM), which were injected only once or twice daily�� Consequently, toddlers are coerced to use an insulin pump, multi-dose insulin regime (Mu�IR), mix or dilute insulins�� This paper highlights the difficulties and proposes a simple solution�� While an insulin pump is the best available option, it is not readily available for everyone�� Mixing insulins is not sufficiently precise in small doses. Although diluting insulin would allow precise dosing and reduce the dose variability secondary to dribbling after injections, it, like insulin mixing, deprives children from using the pen and related child-friendly accessories�� In Mu�IR, we inject 4-5 small doses of insulin instead of 1-2 daily larger doses of WIM�� Thus, on using a half unit (½ unit) insulin pen, a dose of 0��5, 1, 1��5 and 2 units are adjusted in steps of 100%, 50%, 33% or 25%; unlike the advisable 5%-20%�� This does not easily match the tiny erratic meals of grazing toddlers�� Maternal anxiety peaks on watching yo-yoing glycemia�� Carers have to accept either persistently high sugar or wild fluctuation. The risks of such poor glycemic pattern are increasingly recognized�� Using insulin U20 in a ½unit disposable pen allows deci-unit dosing, with 5%-20% dose-tuning, greater accuracy on delivering small doses and reduction of dose variability from dribbling�� eci-unit dosing may help avoid wide glycemic swings and provide the affordable alternative to insulin pumps for toddlers�� e-ci-unit pen materializes the Human Rights of Children, a safer and effective treatment��

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A Comparison of the Handling and Accuracy of Syringe and Vial Versus Prefilled Insulin Pen (FlexPen)

Cited by 53 publications

References 7 publications

Needle with a Novel Attachment Versus Conventional Screw-Thread Needles: A Preference and Usability Test Among Adults with Diabetes and Impaired Manual Dexterity

Needle with a Novel Attachment Versus Conventional Screw-Thread Needles: A Preference and Usability Test Among Adults with Diabetes and Impaired Manual Dexterity

Usability of the Novel Liraglutide 3.0 mg Pen Injector Among Overweight or Obese Adult Patients With or Without Prior Injection Experience

Toddlers’ choice: Yo-Yoing diabetes control or deci-unit insulin dosing?

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