A comparison of the efficacy of 70% v/v isopropyl alcohol with either 0.5% w/v or 2% w/v chlorhexidine gluconate for skin preparation before harvest of the long saphenous vein used in coronary artery bypass grafting

The association between implementation of second-tier prevention practices and CLABSI incidence: A national survey

“…36 A number of studies have suggested that 0.5% CHD in alcohol is less effective in eradicating microbes from skin compared with 2% CHD in alcohol. 37,38 In the present survey, 71% of ICUs used single-use vials containing 2% CHD during line insertion, compared with only 25% for line maintenance. Lower CLABSI rates were observed in ICUs using 2% CHD, yet the difference did not reach statistical significance, possibly due to the small sample size.…”

Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections: a systematic review, GRADE assessment, and network meta-analysis

“…From these reports, 67 full texts were reviewed (figure 1). We included 33 RCTs [5][6][7][8][9][10][11][13][14][15][16][17][18][19][20][21][22][23][24][25][27][28][29][30][31][32][33][34]36,38,[40][41][42] in the systematic review, of which 27 RCTs with 17 735 patients were included in the network meta-analysis. This systematic review includes 37 comparisons.…”

Hautantiseptik

“…Die Daten dieser 13 Studien sind in Tab. 3 zusammengestellt und teilweise nur bedingt aussagekräftig 25 , da beispielsweise in 3 der Studien weder die Art des Alkohols noch seine Konzentration beschrieben wurde 26 27 28 , in 1 Studie die Konzentration des Alkohols außerhalb des wirksamen Bereichs lag 29 und in 4 Studien die Stichproben mit weniger als 100 Probanden zu klein für eine robuste vergleichende Bewertung waren 29 30 31 32 . Die Dauer der jeweiligen Anwendung ist nur in 4 Studien beschrieben und lag zwischen 30 s und 5 min 29 30 32 33 .…”

“…Im unmittelbaren Vergleich zwischen 0,5 % bzw. 2 % CHG in 70 % Isopropanol war kein signifikanter Unterschied in den Infektionsraten zu finden [30].…”