“…29 The substrate material of a ceramic restoration also influences its fracture resistance. 29,35,36 The elastic modulus of the substrate used in vitro needs to be close to the range reported for human dentin (15)(16)(17)(18)(19)(20), to ensure clinically relevant results. 29 In recent in vitro studies, 21,24 the elastic moduli of the substrates was different from human dentin, potentially limiting clinical validity of results.…”