A comparison of the effects of saline imbibition and water deprivation on the composition of the blood, urine and pituitary neural lobe of the gerbil (Meriones unguiculatus)

Donaldson, Kenneth; Edwards, B. A.

doi:10.1016/0300-9629(81)90313-3

Cited by 15 publications

(5 citation statements)

References 13 publications

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“…This could explain the differences in HA between the two species observed under normal conditions, since ADH has been shown to activate the HA degrading enzyme hyaluronidase (Ivanova & Melidi, 1999). Differences in ADH handling have been studied: during long times of water deprivation, the ADH depletion is smaller in the gerbil, thereby suggesting that the synthesis ability is greater (Donaldson & Edwards, 1981). In a study of the activity of the hypothalamus‐neurohypophysis during rehydration, Edwards (1984) provided further evidence of this by showing that water deprivation for 3 or 5 days resulted in the same degree of ADH depletion but that the ADH stores were replenished much faster in the gerbil.…”

Section: Discussionmentioning

confidence: 99%

Renomedullary and intestinal hyaluronan content during body water excess: a study in rats and gerbils

Göransson

Johnsson²,

Nylander

et al. 2002

The Journal of Physiology

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Our previous studies in rats have suggested a role for renomedullary hyaluronan (HA) in water homeostasis. The gerbil is known for its unique ability to conserve water. In the present study renal papillary and intestinal HA were compared between groups of anaesthetized gerbils and rats before and after up to 6 h of i.v. water loading. Baseline papillary HA in gerbils was only 37 % of that in the rat. Water loading in rats increased the papillary HA content. Elevation was maximal (+27 %, P < 0.05) after 2 h of water loading and then declined to control levels after 6 h of water loading (+3 %, n.s.). In contrast, the gerbil responded with a decreased papillary HA content during water loading. The depression was maximal after 2 h (‐49 %, P < 0.05) and was still 41 % below the control values after 6 h (P < 0.05). The urine flow rate increased rapidly in the rat and its maximum, 21 times above the control level (P < 0.05), occurred at the HA peak, i.e. after 2 h of water loading while in the gerbil, the urine flow rate increased slowly and slightly and was only six times above control values after 6 h of water loading (P < 0.05). The HA content along the intestine was similar in the two species: lowest in the duodenum and jejunum and highest in the distal colon. To conclude, in the rat, the elevation of papillary interstitial HA during acute water loading would counteract water reabsorption by changing the physico‐chemical characteristics of the interstitial matrix favouring rapid water diuresis. This would work as a complement to the powerful regulation by ADH. The gerbil has a diametrically different regulation of papillary HA turnover during water loading. The decreased papillary HA level during water loading and the slow and small diuretic response may represent a genetic difference in adaptation to enhance the ability to conserve water in an arid environment.

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Section: Discussionmentioning

confidence: 99%

Renomedullary and intestinal hyaluronan content during body water excess: a study in rats and gerbils

Göransson

Johnsson²,

Nylander

et al. 2002

The Journal of Physiology

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“…Introduction to experimental design and use of primary literature. The second lab unit, on renal physiology, investigates osmoregulation in gerbils and was initially developed around a set of core papers from the primary literature on salt and water balance in gerbils (2,3). This lab unit is probably the most important one of the semester, because it models a more sophisticated type of investigative inquiry expected of student-designed experiments in this course (i.e., going beyond the DYO of introductorylevel courses).…”

Section: Guided Inquiry As a Model For Investigative Labsmentioning

confidence: 99%

Guided Development of Independent Inquiry in an Anatomy/Physiology Laboratory

Chaplin

2003

Advances in Physiology Education

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Student-originated projects are increasingly utilized in the biology laboratory as a means of engaging students and revitalizing the laboratory experience by allowing them one to two weeks to collect data on a manipulated variable of their choice by use of an introduced technique. Such experiments fail as good models of investigative learning when they place more emphasis on novel ideas than on hypothesis testing, experimental design, statistical rigor, or use of the primary literature. In addition, students get used to the routine and tend to design the same type of simplistic experiments in each course unless challenged. Laboratories in a Comparative Anatomy and Physiology course at the University of St. Thomas were reorganized to encourage the development of investigative skills in a stepwise fashion throughout the semester. Initial labs concentrated on experimental design and statistical analysis, then use of the primary literature in interpretation of the data was emphasized, and finally, students were asked to design their experiments and analyze their data on the basis of models from the primary literature.

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“…This animal was chosen because of its unusual capacity to retain body water. The gerbil resides in the semidesert areas of East Asia and is known for its capacity to minimize the effects of water deprivation (Donaldson and Edwards, 1981;Edwards etal, 1983).…”

Section: Introductionmentioning

confidence: 99%

The surface morphology of the endolymphatic sac of the Mongolian gerbil (Meriones unguiculatus) (A scanning electron microscopic study)

1988

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A scanning electron microscopic study of the endolymphatic sac of the mongolian gerbil is presented. As described in other animal species and in man. three rather distinct regions on the epithelial surface can also be recognized in this rodent. Light and dark cells are seen to line the sac epithelium throughout. At the level of the intermediate portion, however, a different cell-type—the granular cell—is present, with its luminal surface covered by large amounts of solid material.On the basis of light and transmission electron microscopic studies presented elsewhere, a higher degree of functional specialization in this portion of the gerbilline sac is proposed.

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A comparison of the effects of saline imbibition and water deprivation on the composition of the blood, urine and pituitary neural lobe of the gerbil (Meriones unguiculatus)

Cited by 15 publications

References 13 publications

Renomedullary and intestinal hyaluronan content during body water excess: a study in rats and gerbils

Renomedullary and intestinal hyaluronan content during body water excess: a study in rats and gerbils

Guided Development of Independent Inquiry in an Anatomy/Physiology Laboratory

The surface morphology of the endolymphatic sac of the Mongolian gerbil (Meriones unguiculatus) (A scanning electron microscopic study)

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