A comparison of the effects of three different luteal phase support protocols on in vitro fertilization outcomes: a randomized clinical trial

Var, Turgut; Tonguç, Esra; Doğanay, Melike; Gülerman, Cavidan; Güngör, Tayfun; Mollamahmutoğlu, Leyla

doi:10.1016/j.fertnstert.2010.06.057

Cited by 27 publications

(16 citation statements)

References 36 publications

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“…Recently, additional GnRHa treatments administered along with progesterone have been reported to generate better result than progesterone treatment alone [4]. While the scientific debate continues, progesterone has become the treatment of choice, regardless of the fact that the literature offers conflicting data on the optimal route of progesterone administration during IVF [1,3,6]. Previous studies claimed that due to the first passing effect through the liver, oral progesterones were the least effective forms, contrary to the intramuscular forms, which were reported to be the most efficient [19].…”

Section: Discussionmentioning

confidence: 99%

“…Over the years, these results have been supported by placebo-controlled trials [1,3], and it became clear that luteal phase support (LPS) had a positive effect on the outcome of IVF cycles using GnRHa protocols, as well as GnRH antagonist [1,3]. To date, progesterone remains to be the treatment of choice although many agents, including hCG, progesterone, estradiol and GnRHa, or their combinations, have been proposed for luteal support [1,[3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Progesterone vaginal capsule versus vaginal gel for luteal support in normoresponder women undergoing long agonist IVF/ICSI cycles

Gün

Özdamar²,

Şahin³

et al. 2016

Ginekol Pol

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Objectives: The aim of the study was to investigate the effects of two different vaginal progesterone forms, administered for luteal phase support, on pregnancy outcomes in normoresponder women aged < 35, who underwent long agonist IVF/ICSI-ET cycles. Material and methods:A retrospective cohort analysis was designed. Normoresponders with primary infertility, who underwent IVF/ICSI-ET cycles employing GnRH analogue and who received progesterone as either capsule or gel form for LPS following a single embryo transfer, were analyzed. The cycles were categorized into two groups: micronized progesterone vaginal capsule 600 mg/day (Group 1, n = 78) and progesterone vaginal gel 180 mg/day (Group 2, n = 99). Positive β-hCG, clinical pregnancy and ongoing pregnancy rates were analyzed.Results: Both, demographic and stimulation characteristics were comparable between the groups. No difference was observed between the capsule and the gel groups regarding positive β-hCG (33.3% and 28.3%, respectively; p = 0.580), clinical pregnancy (26.9% and 22.2%, respectively; p = 0.584), and ongoing pregnancy rates (21.8% and 20.2%, respectively; p = 0.942) after treatment completion. Conclusions:In long agonist IVF/ICSI-ET cycles, positive β-hCG, clinical pregnancy and ongoing pregnancy rates do not significantly differ between normoresponder patients receiving micronized progesterone vaginal capsule and those receiving progesterone vaginal gel for LPS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Progesterone vaginal capsule versus vaginal gel for luteal support in normoresponder women undergoing long agonist IVF/ICSI cycles

Gün

Özdamar²,

Şahin³

et al. 2016

Ginekol Pol

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“…132 Alternatively, hCG supplementation may be used. 133 A 2011 Cochrane review found that there was a significant increase in the clinical pregnancy rate when progesterone was combined with transdermal or oral oestrogen. Progesterone and hCG luteal support produce similar results, but hCG supplementation significantly increases the risk of OHSS.…”

Section: Orthodox Medical Protocolmentioning

confidence: 99%

Acupuncture during ART

Szmelskyj

2015

Acupuncture for IVF and Assisted Reproduction

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“…The role of E2 luteal support is still debated after more than a decade of use. Previous meta analysis [18] and an update [62] and more recent randomized trials [63,64] reported beneficial effects of adding E2 to luteal progesterone support. In our study [63] two hundred seventy-four women undergoing first ICSI cycles were randomized after ovum pickup into three groups of luteal support .…”

Section: Estrogenmentioning

confidence: 99%