A Comparison of the Effects of Epidural and Spinal Anesthesia With Ischemia-Reperfusion Injury on the Rat Transverse Rectus Abdominis Musculocutaneous Flap

Abstract

The purpose of this study is to compare the effects of spinal and epidural anesthesia on a rat transverse rectus abdominus myocutaneous flap ischemia-reperfusion injury model.Forty Sprague-Dawley rats were divided into 4 experimental groups: group I (n = 10), sham group; group II (n = 10), control group; group III (n = 10), epidural group; and group IV (n = 10), spinal group. After the elevation of the transverse rectus abdominus myocutaneous flaps, all groups except for the sham group were subjected to normothermic no-flow ischemia for 4 hours, followed by a reperfusion period of 2 hours. At the end of the reperfusion period, biochemical and histopathological evaluations were performed on tissue samples.Although there was no significant difference concerning the malonyldialdehyde, nitric oxide, and paraoxonase levels in the spinal and epidural groups, the total antioxidant state levels were significantly increased, and the total oxidative stress levels were significantly decreased in the epidural group in comparison to the spinal group. The pathological evaluation showed that findings related to inflammation, nuclear change rates and hyalinization were significantly higher in the spinal group compared with the epidural group.Epidural anesthesia can be considered as a more suitable method that enables a decrease in ischemia-reperfusion injuries in the muscle flaps.

Emergent Reimplantation of Arm with Interscalene Block

“…IRI may occur in such case according to ischemia time and replanted size. It was stated that neuroaxial block enables a decrease in ischemiareperfusion injuries in the muscle flaps [5].…”

Comparison of the Effects of Inhalation and Spinal Anesthesia on Microcirculation in Transverse Rectus Abdominis and Gluteus Maximus Muscle-Skin Flap Applications in Experimental Rat Models

“…Hamilton 100 μL gas-tight syringes were advanced 15 mm through the polyethylene tube using a 28-gauge needle. An injection of 2% lidocaine [Aritmal ® , Osel İlaç San ve Tic AŞ, Istanbul, Turkey] 25 μL solution was administered (Acar et al, 2013).…”

Evaluatıon of effects of bupıvacaıne and ısoflurane on pancreas damage after renal ıschemıa-reperfusıon ınjury: An experımental study

“…Menting et al reported that repetitive administration of isoflurane daily, exerted a protective effect against renal I/R injury while single-dose isoflurane did not have the same effect [10]. Acar et al compared the protective effects of spinal and epidural anesthesia against I/R injury created in transverse rectus abdominis muscle and reported that epidural anesthesia is superior to spinal anesthesia in preventing I/R injury [11].…”