A comparison of the effects of Nonoxynol-9 and chlorhexidine on sperm motility

Louis, Suzanne M.; Pearson, Richard M.

doi:10.1016/0010-7824(85)90108-8

Cited by 21 publications

(12 citation statements)

References 16 publications

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“…The IC50 value we have obtained for the effect of nonoxynol-9 on sperm motility is consistent with results obtained previously with the same technique (Hong et a1 1983;Louis & Pearson 1985).…”

Section: Discussionsupporting

confidence: 93%

A modified transmembrane migration method for evaluating the spermicidal potency of some nonoxynol compounds

1988

Journal of Pharmacy and Pharmacology

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The transmembrane migration technique, a simple method in-vitro for quantitatively assessing the effects of a drug on human sperm motility, has been evaluated. The original method has been modified to include a preincubation step, and the incubation time has been reduced to 90 min. In semen samples possessing sperm concentrations of less than 75 x 12(6) spermatozoa mL-1 the volume of the lower reservoir has been reduced to 1 mL. This modified method has been used to compare the spermicidal potency of the widely employed non-ionic surfactant nonoxynol-9, with nonoxynol-5 and nonoxynol-15 (containing, respectively, fewer and more ethylene oxide units per molecule). The rank order of spermicidal potency of the compounds evaluated was nonoxynol-9 = nonoxynol-5 greater than nonoxynol-15.

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Section: Discussionsupporting

confidence: 93%

A modified transmembrane migration method for evaluating the spermicidal potency of some nonoxynol compounds

1988

Journal of Pharmacy and Pharmacology

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“…Our results showed that within this 20 min period about 75% of the dilution had already taken place ( Figure 1) . Hong et al (1981b) demonstrated that the effect of propranolol on sperm motility can be antagonised by caffeine, this reversibility occurring after treating spermatozoa with propranolol for 5 min (Hong, 1982 (Hong et al, , 1984(Hong et al, , 1985Jiang et al, 1984;Louis & Pearson, 1985).…”

Section: Discussionmentioning

confidence: 90%

A modified trans‐membrane migration method for measuring the effect of drugs on sperm motility.

Raoof

Pearson

Turner

1987

Brit J Clinical Pharma

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“…A great advantage of nonoxynol-9 is its ability to inhibit the growth of some organisms responsible for sexually transmitted diseases [5,6]. Nonoxynol-9 toxicity is controversial [3,[7][8][9][10]; no strong evidence of systemic effects in humans has been reported [11].…”

Section: Introductionmentioning

confidence: 99%

Assessment of a new modified soft jelly capsule containing nonoxynol as spermicide contraceptive

Recio

Bassol

1992

Adv Contracept

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The mean rupture time, after its vaginal insertion, of a new modified soft jelly capsule containing nonoxynol-9 (DF-486) was investigated in 40 women. The subjects were randomly allocated to 8 study groups. The capsules remained in the vagina from 2-13 minutes. Vaginal infection, vaginal dryness, and multiparity, were recorded. Capsule rupture was not observed at minute 2; 20% of capsules that remained in the vagina 3 minutes suffered rupture, as did 80% of capsules that remained 4, 5 and 7 minutes, and 100% of those remaining 9 minutes or more. The mean rupture time of the studied capsules was 8.2 minutes with 95% confidence limits of 6.2 and 8.8 minutes. At minutes 2-7, vaginal infection, dryness and tone diminution probably accounted for lack of rupture; after minute 7, these factors did not influence capsule rupture.

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A comparison of the effects of Nonoxynol-9 and chlorhexidine on sperm motility

Cited by 21 publications

References 16 publications

A modified transmembrane migration method for evaluating the spermicidal potency of some nonoxynol compounds

A modified transmembrane migration method for evaluating the spermicidal potency of some nonoxynol compounds

A modified trans‐membrane migration method for measuring the effect of drugs on sperm motility.

Assessment of a new modified soft jelly capsule containing nonoxynol as spermicide contraceptive

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